Publications:

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Multiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2-, PIK3CA-mutated breast cancers.

Genome Medicine

Hutchinson, Katherine E KE; Chen, Jessica W JW; Savage, Heidi M HM; Stout, Thomas J TJ; Schimmoller, Frauke F; Cortés, Javier J; Dent, Susan S; Harbeck, Nadia N; Jacot, William W; Krop, Ian I; Trabucco, Sally E SE; Sivakumar, Smruthy S; Sokol, Ethan S ES; Wilson, Timothy R TR

Publication Date: 2023-04-26

Variant appearance in text: PIK3CA: K111N

PubMed Link: 37101291

Variant Present in the following documents:

• 13073_2023_1181_MOESM1_ESM.pdf

View BVdb publication page

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Antitumor activity of the PI3K δ-sparing inhibitor MEN1611 in PIK3CA mutated, trastuzumab-resistant HER2 + breast cancer.

Breast Cancer Research And Treatment

Fiascarelli, Alessio A; Merlino, Giuseppe G; Capano, Stefania S; Talucci, Simone S; Bisignano, Diego D; Bressan, Alessandro A; Bellarosa, Daniela D; Carrisi, Corrado C; Paoli, Alessandro A; Bigioni, Mario M; Tunici, Patrizia P; Irrissuto, Clelia C; Salerno, Massimiliano M; Arribas, Joaquin J; de Stanchina, Elisa E; Scaltriti, Maurizio M; Binaschi, Monica M

Publication Date: 2023-03-13

Variant appearance in text: PIK3CA: K111N

PubMed Link: 36913051

Variant Present in the following documents:

• Main text
• 10549_2023_Article_6895.pdf

View BVdb publication page

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Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: PIK3CA: 333G>C; Lys111Asn

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

View BVdb publication page

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ESR1 gene amplification and MAP3K mutations are selected during adjuvant endocrine therapies in relapsing Hormone Receptor-positive, HER2-negative breast cancer (HR+ HER2- BC).

Plos Genetics

Ferrando, Lorenzo L; Vingiani, Andrea A; Garuti, Anna A; Vernieri, Claudio C; Belfiore, Antonino A; Agnelli, Luca L; Dagrada, Gianpaolo G; Ivanoiu, Diana D; Bonizzi, Giuseppina G; Munzone, Elisabetta E; Lippolis, Luana L; Dameri, Martina M; Ravera, Francesco F; Colleoni, Marco M; Viale, Giuseppe G; Magnani, Luca L; Ballestrero, Alberto A; Zoppoli, Gabriele G; Pruneri, Giancarlo G

Publication Date: 2023-01-03

Variant appearance in text: rs1057519934

PubMed Link: 36595552

Variant Present in the following documents:

• pgen.1010563.s004.xlsx, sheet 1

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Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics

G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A

Publication Date: 2022

Variant appearance in text: rs1057519934

PubMed Link: 36561320

Variant Present in the following documents:

• Table2.xlsx, sheet 5
• Table3.xlsx, sheet 1

View BVdb publication page

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Advantages and Limitations of Monitoring Circulating Tumor DNA Levels to Predict the Prognosis of Patients Diagnosed With Gastric Cancer.

Biomarker Insights

He, Wan W; Yang, Jingxin J; Sun, Xiao X; Jiang, Shunda S; Jiang, Jinchan J; Liu, Ming M; Mu, Tianhao T; Li, Yingmei Y; Zhang, Xiaoni X; Duan, Jingxian J; Xu, Ruilian R

Publication Date: 2022

Variant appearance in text: PIK3CA: 333G>C; K111N

PubMed Link: 36533271

Variant Present in the following documents:

• sj-xlsx-2-bmi-10.1177_11772719221141525.xlsx, sheet 1

View BVdb publication page

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Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.

Nature Communications

Sivakumar, Smruthy S; Jin, Dexter X DX; Tukachinsky, Hanna H; Murugesan, Karthikeyan K; McGregor, Kimberly K; Danziger, Natalie N; Pavlick, Dean D; Gjoerup, Ole O; Ross, Jeffrey S JS; Harmon, Robert R; Chung, Jon J; Decker, Brennan B; Dennis, Lucas L; Frampton, Garrett M GM; Molinero, Luciana L; Oesterreich, Steffi S; Venstrom, Jeffrey M JM; Oxnard, Geoffrey R GR; Hegde, Priti S PS; Sokol, Ethan S ES

Publication Date: 2022-12-05

Variant appearance in text: PIK3CA: K111N

PubMed Link: 36470901

Variant Present in the following documents:

• 41467_2022_35245_MOESM4_ESM.xlsx, sheet 12

View BVdb publication page

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Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications

Boström, Martin M; Larsson, Erik E

Publication Date: 2022-11-17

Variant appearance in text: PIK3CA: K111N

PubMed Link: 36396655

Variant Present in the following documents:

• 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1

View BVdb publication page

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Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics

Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q

Publication Date: 2022-11-04

Variant appearance in text: PIK3CA: 333G>C; K111N

PubMed Link: 36333792

Variant Present in the following documents:

• 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1

View BVdb publication page

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Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.

Nature Communications

Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A

Publication Date: 2022-07-13

Variant appearance in text: PIK3CA: 333G>C; Lys111Asn

PubMed Link: 35831314

Variant Present in the following documents:

• 41467_2022_31809_MOESM8_ESM.xlsx, sheet 3

View BVdb publication page

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Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.

Nature Communications

Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX

Publication Date: 2022-06-15

Variant appearance in text: PIK3CA: K111N

PubMed Link: 35705558

Variant Present in the following documents:

• 41467_2022_30496_MOESM2_ESM.xls, sheet 1

View BVdb publication page

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Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer.

Nature Communications

Hao, Yujun Y; He, Baoyu B; Wu, Liping L; Li, Yamu Y; Wang, Chao C; Wang, Ting T; Sun, Longci L; Zhang, Yanhua Y; Zhan, Yangyang Y; Zhao, Yiqing Y; Markowitz, Sanford S; Veigl, Martina M; Conlon, Ronald A RA; Wang, Zhenghe Z

Publication Date: 2022-04-13

Variant appearance in text: PIK3CA: K111N

PubMed Link: 35418124

Variant Present in the following documents:

• Main text
• 41467_2022_Article_29585.pdf

View BVdb publication page

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Molecular landscape of TP53 mutations in breast cancer and their utility for predicting the response to HER-targeted therapy in HER2 amplification-positive and HER2 mutation-positive amplification-negative patients.

Cancer Medicine

Liu, Binliang B; Yi, Zongbi Z; Guan, Yanfang Y; Ouyang, Quchang Q; Li, Chunxiao C; Guan, Xiuwen X; Lv, Dan D; Li, Lixi L; Zhai, Jingtong J; Qian, Haili H; Xu, Binghe B; Ma, Fei F; Zeng, Yixin Y

Publication Date: 2022-07

Variant appearance in text: PIK3CA: 333G>C; K111N

PubMed Link: 35393784

Variant Present in the following documents:

• CAM4-11-2767-s001.xlsx, sheet 1

View BVdb publication page

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A Comprehensive Survey of Genomic Mutations in Breast Cancer Reveals Recurrent Neoantigens as Potential Therapeutic Targets.

Frontiers In Oncology

Zhou, Si S; Liu, Songming S; Zhao, Lijian L; Sun, Hai-Xi HX

Publication Date: 2022

Variant appearance in text: PIK3CA: K111N

PubMed Link: 35387130

Variant Present in the following documents:

• Table_2.xlsx, sheet 1

View BVdb publication page

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PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.

Jco Precision Oncology

Rasti, Aryana R AR; Guimaraes-Young, Amy A; Datko, Farrah F; Borges, Virginia F VF; Aisner, Dara L DL; Shagisultanova, Elena E

Publication Date: 2022-03

Variant appearance in text: PIK3CA: K111N

PubMed Link: 35357905

Variant Present in the following documents:

• po-6-e2100370.pdf

View BVdb publication page

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FTY720 in resistant human epidermal growth factor receptor 2-positive breast cancer.

Scientific Reports

Chung, Wei-Pang WP; Huang, Wei-Lun WL; Liao, Wei-An WA; Hung, Chun-Hua CH; Chiang, Chi-Wu CW; Cheung, Chun Hei Antonio CHA; Su, Wu-Chou WC

Publication Date: 2022-01-07

Variant appearance in text: PIK3CA: K111N

PubMed Link: 34997132

Variant Present in the following documents:

• Main text
• 41598_2021_Article_4328.pdf

View BVdb publication page

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FTY720 in resistant human epidermal growth factor receptor 2-positive breast cancer.

Scientific Reports

Chung, Wei-Pang WP; Huang, Wei-Lun WL; Liao, Wei-An WA; Hung, Chun-Hua CH; Chiang, Chi-Wu CW; Cheung, Chun Hei Antonio CHA; Su, Wu-Chou WC

Publication Date: 2022-01-07

Variant appearance in text: PIK3CA: K111N

PubMed Link: 34997132

Variant Present in the following documents:

• Main text
• 41598_2021_Article_4328.pdf

View BVdb publication page

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Oral Squamous Cell Carcinoma in Young Patients Show Higher Rates of EGFR Amplification: Implications for Novel Personalized Therapy.

Frontiers In Oncology

Satgunaseelan, Laveniya L; Porazinski, Sean S; Strbenac, Dario D; Istadi, Aji A; Willet, Cali C; Chew, Tracy T; Sadsad, Rosemarie R; Palme, Carsten E CE; Lee, Jenny H JH; Boyer, Michael M; Yang, Jean Y H JYH; Clark, Jonathan R JR; Pajic, Marina M; Gupta, Ruta R

Publication Date: 2021

Variant appearance in text: PIK3CA: K111N

PubMed Link: 34912708

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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Identification of Immune-Related Gene Signatures in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma.

Frontiers In Immunology

Li, Na N; Wang, Jiahong J; Zhan, Xianquan X

Publication Date: 2021

Variant appearance in text: PIK3CA: 333G>C; K111N

PubMed Link: 34887858

Variant Present in the following documents:

• Table_3.xlsx, sheet 1

View BVdb publication page

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Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.

The Journal Of Clinical Investigation

Jin, Nan N; Keam, Bhumsuk B; Cho, Janice J; Lee, Michelle J MJ; Kim, Hye Ryun HR; Torosyan, Hayarpi H; Jura, Natalia N; Ng, Patrick Ks PK; Mills, Gordon B GB; Li, Hua H; Zeng, Yan Y; Barbash, Zohar Z; Tarcic, Gabi G; Kang, Hyunseok H; Bauman, Julie E JE; Kim, Mi-Ok MO; VanLandingham, Nathan K NK; Swaney, Danielle L DL; Krogan, Nevan J NJ; Johnson, Daniel E DE; Grandis, Jennifer R JR

Publication Date: 2021-11-15

Variant appearance in text: PIK3CA: K111N

PubMed Link: 34779417

Variant Present in the following documents:

• Main text

View BVdb publication page

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PI3Kinase Inhibition in Hormone Receptor-Positive Breast Cancer.

International Journal Of Molecular Sciences

Dhakal, Ajay A; Acharya, Luna L; O'Regan, Ruth R; Gandhi, Shipra S; Falkson, Carla C

Publication Date: 2021-11-02

Variant appearance in text: PIK3CA: K111N

PubMed Link: 34769309

Variant Present in the following documents:

• Main text
• ijms-22-11878.pdf

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: PIK3CA: K111N

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment.

Nature Communications

Sun, Hua H; Cao, Song S; Mashl, R Jay RJ; Mo, Chia-Kuei CK; Zaccaria, Simone S; Wendl, Michael C MC; Davies, Sherri R SR; Bailey, Matthew H MH; Primeau, Tina M TM; Hoog, Jeremy J; Mudd, Jacqueline L JL; Dean, Dennis A DA; Patidar, Rajesh R; Chen, Li L; Wyczalkowski, Matthew A MA; Jayasinghe, Reyka G RG; Rodrigues, Fernanda Martins FM; Terekhanova, Nadezhda V NV; Li, Yize Y; Lim, Kian-Huat KH; Wang-Gillam, Andrea A; Van Tine, Brian A BA; Ma, Cynthia X CX; Aft, Rebecca R; Fuh, Katherine C KC; Schwarz, Julie K JK; Zevallos, Jose P JP; Puram, Sidharth V SV; Dipersio, John F JF; , ; Davis-Dusenbery, Brandi B; Ellis, Matthew J MJ; Lewis, Michael T MT; Davies, Michael A MA; Herlyn, Meenhard M; Fang, Bingliang B; Roth, Jack A JA; Welm, Alana L AL; Welm, Bryan E BE; Meric-Bernstam, Funda F; Chen, Feng F; Fields, Ryan C RC; Li, Shunqiang S; Govindan, Ramaswamy R; Doroshow, James H JH; Moscow, Jeffrey A JA; Evrard, Yvonne A YA; Chuang, Jeffrey H JH; Raphael, Benjamin J BJ; Ding, Li L

Publication Date: 2021-08-24

Variant appearance in text: PIK3CA: K111N

PubMed Link: 34429404

Variant Present in the following documents:

• 41467_2021_25177_MOESM8_ESM.xlsx, sheet 1

View BVdb publication page

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Immunogenomic determinants of tumor microenvironment correlate with superior survival in high-risk neuroblastoma.

Journal For Immunotherapy Of Cancer

Bao, Riyue R; Spranger, Stefani S; Hernandez, Kyle K; Zha, Yuanyuan Y; Pytel, Peter P; Luke, Jason J JJ; Gajewski, Thomas F TF; Volchenboum, Samuel L SL; Cohn, Susan L SL; Desai, Ami V AV

Publication Date: 2021-07

Variant appearance in text: PIK3CA: K111N

PubMed Link: 34272305

Variant Present in the following documents:

• Main text
• jitc-2021-002417.pdf

View BVdb publication page

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Survival and prognosis analyses of concurrent PIK3CA mutations in EGFR mutant non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors.

American Journal Of Cancer Research

Qiu, Xiaotong X; Wang, Yong Y; Liu, Fen F; Peng, Lihong L; Fang, Chen C; Qian, Xiaoyin X; Zhang, Xinwei X; Wang, Qian Q; Xiao, Zhehao Z; Chen, Renfang R; Yuan, Shangkun S; Li, Yong Y

Publication Date: 2021

Variant appearance in text: PIK3CA: K111N

PubMed Link: 34249454

Variant Present in the following documents:

• Main text

View BVdb publication page

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The Novel Oral mTORC1/2 Inhibitor TAK-228 Reverses Trastuzumab Resistance in HER2-Positive Breast Cancer Models.

Cancers

Sanz-Álvarez, Marta M; Martín-Aparicio, Ester E; Luque, Melani M; Zazo, Sandra S; Martínez-Useros, Javier J; Eroles, Pilar P; Rovira, Ana A; Albanell, Joan J; Madoz-Gúrpide, Juan J; Rojo, Federico F

Publication Date: 2021-06-03

Variant appearance in text: PI3K: K111N

PubMed Link: 34204960

Variant Present in the following documents:

• Main text
• cancers-13-02778.pdf

View BVdb publication page

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Improvement of Neoantigen Identification Through Convolution Neural Network.

Frontiers In Immunology

Hao, Qing Q; Wei, Ping P; Shu, Yang Y; Zhang, Yi-Guan YG; Xu, Heng H; Zhao, Jun-Ning JN

Publication Date: 2021

Variant appearance in text: PIK3CA: K111N

PubMed Link: 34113354

Variant Present in the following documents:

• Table_1.xlsx, sheet 31
• Table_1.xlsx, sheet 18
• Table_1.xlsx, sheet 3

View BVdb publication page

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Neratinib plus trastuzumab is superior to pertuzumab plus trastuzumab in HER2-positive breast cancer xenograft models.

Npj Breast Cancer

Veeraraghavan, Jamunarani J; Gutierrez, Carolina C; Sethunath, Vidyalakshmi V; Mehravaran, Sepideh S; Giuliano, Mario M; Shea, Martin J MJ; Mitchell, Tamika T; Wang, Tao T; Nanda, Sarmistha S; Pereira, Resel R; Davis, Robert R; Goutsouliak, Kristina K; Qin, Lanfang L; De Angelis, Carmine C; Diala, Irmina I; Lalani, Alshad S AS; Nagi, Chandandeep C; Hilsenbeck, Susan G SG; Rimawi, Mothaffar F MF; Osborne, C Kent CK; Schiff, Rachel R

Publication Date: 2021-05-27

Variant appearance in text: PIK3CA: K111N

PubMed Link: 34045483

Variant Present in the following documents:

• Main text

View BVdb publication page

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A Phase I Study of Alpelisib in Combination with Trastuzumab and LJM716 in Patients with PIK3CA-Mutated HER2-Positive Metastatic Breast Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Jhaveri, Komal K; Drago, Joshua Z JZ; Shah, Payal Deepak PD; Wang, Rui R; Pareja, Fresia F; Ratzon, Fanni F; Iasonos, Alexia A; Patil, Sujata S; Rosen, Neal N; Fornier, Monica N MN; Sklarin, Nancy T NT; Chandarlapaty, Sarat S; Modi, Shanu S

Publication Date: 2021-07-15

Variant appearance in text: PIK3CA: K111N

PubMed Link: 33947692

Variant Present in the following documents:

• Main text

View BVdb publication page

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Spatially interacting phosphorylation sites and mutations in cancer.

Nature Communications

Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L

Publication Date: 2021-04-19

Variant appearance in text: PIK3CA: K111N

PubMed Link: 33875650

Variant Present in the following documents:

• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 5
• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 6
• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 1

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Comprehensive omic characterization of breast cancer in Mexican-Hispanic women.

Nature Communications

Romero-Cordoba, Sandra L SL; Salido-Guadarrama, Ivan I; Rebollar-Vega, Rosa R; Bautista-Piña, Veronica V; Dominguez-Reyes, Carlos C; Tenorio-Torres, Alberto A; Villegas-Carlos, Felipe F; Fernández-López, Juan C JC; Uribe-Figueroa, Laura L; Alfaro-Ruiz, Luis L; Hidalgo-Miranda, Alfredo A

Publication Date: 2021-04-14

Variant appearance in text: PIK3CA: K111N

PubMed Link: 33854067

Variant Present in the following documents:

• 41467_2021_22478_MOESM8_ESM.xlsx, sheet 9
• 41467_2021_22478_MOESM8_ESM.xlsx, sheet 7

View BVdb publication page

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Phase Ib Trial of Copanlisib, A Phosphoinositide-3 Kinase (PI3K) Inhibitor, with Trastuzumab in Advanced Pre-Treated HER2-Positive Breast Cancer "PantHER".

Cancers

Keegan, Niamh M NM; Furney, Simon J SJ; Walshe, Janice M JM; Gullo, Giuseppe G; Kennedy, M John MJ; Smith, Diarmuid D; McCaffrey, John J; Kelly, Catherine M CM; Egan, Keith K; Kerr, Jennifer J; Given, Mark M; O'Donovan, Peter P; Hernando, Andres A; Teiserskiene, Ausra A; Parker, Imelda I; Kay, Elaine E; Farrelly, Angela A; Carr, Aoife A; Calzaferri, Giulio G; McDermott, Ray R; Keane, Maccon M MM; Grogan, Liam L; Breathnach, Oscar O; Morris, Patrick G PG; Toomey, Sinead S; Hennessy, Bryan T BT

Publication Date: 2021-03-11

Variant appearance in text: PIK3CA: K111N

PubMed Link: 33799597

Variant Present in the following documents:

• Main text

View BVdb publication page

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Three-dimensional understanding of the morphological complexity of the human uterine endometrium.

Iscience

Yamaguchi, Manako M; Yoshihara, Kosuke K; Suda, Kazuaki K; Nakaoka, Hirofumi H; Yachida, Nozomi N; Ueda, Haruka H; Sugino, Kentaro K; Mori, Yutaro Y; Yamawaki, Kaoru K; Tamura, Ryo R; Ishiguro, Tatsuya T; Motoyama, Teiichi T; Watanabe, Yu Y; Okuda, Shujiro S; Tainaka, Kazuki K; Enomoto, Takayuki T

Publication Date: 2021-04-23

Variant appearance in text: PIK3CA: K111N

PubMed Link: 33796844

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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A next-generation sequencing-based strategy combining microsatellite instability and tumor mutation burden for comprehensive molecular diagnosis of advanced colorectal cancer.

Bmc Cancer

Xiao, Jian J; Li, Wenyun W; Huang, Yan Y; Huang, Mengli M; Li, Shanshan S; Zhai, Xiaohui X; Zhao, Jing J; Gao, Chan C; Xie, Wenzhuan W; Qin, Hao H; Cai, Shangli S; Bai, Yuezong Y; Lan, Ping P; Zou, Yifeng Y

Publication Date: 2021-03-16

Variant appearance in text: N/A

PubMed Link: 33726687

Variant Present in the following documents:

View BVdb publication page

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Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer

Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA

Publication Date: 2021-05

Variant appearance in text: PIK3CA: 333G>C; K111N

PubMed Link: 33704917

Variant Present in the following documents:

• TCA-12-1271-s003.xls, sheet 1

View BVdb publication page

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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: PIK3CA: 333G>C; K111N

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
• 41467_2020_20162_MOESM10_ESM.xlsx, sheet 1

View BVdb publication page

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Predictive Biomarkers for Immune Checkpoint Inhibitors in Metastatic Breast Cancer.

Cancer Medicine

Sivapiragasam, Abirami A; Ashok Kumar, Prashanth P; Sokol, Ethan S ES; Albacker, Lee A LA; Killian, Jonathan K JK; Ramkissoon, Shakti H SH; Huang, Richard S P RSP; Severson, Eric A EA; Brown, Charlotte A CA; Danziger, Natalie N; McGregor, Kimberly K; Ross, Jeffrey S JS

Publication Date: 2021-01

Variant appearance in text: N/A

PubMed Link: 33314633

Variant Present in the following documents:

View BVdb publication page

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Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells.

Scientific Reports

Fujimoto, Yumi Y; Morita, Tomoko Yamamori TY; Ohashi, Akihiro A; Haeno, Hiroshi H; Hakozaki, Yumi Y; Fujii, Masanori M; Kashima, Yukie Y; Kobayashi, Susumu S SS; Mukohara, Toru T

Publication Date: 2020-12-10

Variant appearance in text: PIK3CA: K111N

PubMed Link: 33303839

Variant Present in the following documents:

• Main text
• 41598_2020_78646_MOESM1_ESM.pdf
• 41598_2020_Article_78646.pdf

View BVdb publication page

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Utility of a custom designed next generation DNA sequencing gene panel to molecularly classify endometrial cancers according to The Cancer Genome Atlas subgroups.

Bmc Medical Genomics

Miller, Eirwen M EM; Patterson, Nicole E NE; Gressel, Gregory M GM; Karabakhtsian, Rouzan G RG; Bejerano-Sagie, Michal M; Ravi, Nivedita N; Maslov, Alexander A; Quispe-Tintaya, Wilber W; Wang, Tao T; Lin, Juan J; Smith, Harriet O HO; Goldberg, Gary L GL; Kuo, Dennis Y S DYS; Montagna, Cristina C

Publication Date: 2020-11-30

Variant appearance in text: N/A

PubMed Link: 33256706

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Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing.

Nature Communications

Lang, Guan-Tian GT; Jiang, Yi-Zhou YZ; Shi, Jin-Xiu JX; Yang, Fan F; Li, Xiao-Guang XG; Pei, Yu-Chen YC; Zhang, Chen-Hui CH; Ma, Ding D; Xiao, Yi Y; Hu, Peng-Chen PC; Wang, Hai H; Yang, Yun-Song YS; Guo, Lin-Wei LW; Lu, Xun-Xi XX; Xue, Meng-Zhu MZ; Wang, Peng P; Cao, A-Yong AY; Ling, Hong H; Wang, Zhong-Hua ZH; Yu, Ke-Da KD; Di, Gen-Hong GH; Li, Da-Qiang DQ; Wang, Yun-Jin YJ; Yu, Ying Y; Shi, Le-Ming LM; Hu, Xin X; Huang, Wei W; Shao, Zhi-Ming ZM

Publication Date: 2020-11-10

Variant appearance in text: N/A

PubMed Link: 33173047

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Molecular landscape and efficacy of HER2-targeted therapy in patients with HER2-mutated metastatic breast cancer.

Npj Breast Cancer

Yi, Zongbi Z; Rong, Guohua G; Guan, Yanfang Y; Li, Jin J; Chang, Lianpeng L; Li, Hui H; Liu, Binliang B; Wang, Wenna W; Guan, Xiuwen X; Ouyang, Quchang Q; Li, Lixi L; Zhai, Jingtong J; Li, Chunxiao C; Li, Lifeng L; Xia, Xuefeng X; Yang, Ling L; Qian, Haili H; Yi, Xin X; Xu, Binghe B; Ma, Fei F

Publication Date: 2020

Variant appearance in text: PIK3CA: 333G>C; K111N

PubMed Link: 33145402

Variant Present in the following documents:

• 41523_2020_201_MOESM2_ESM.xlsx, sheet 1

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The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.

Frontiers In Immunology

Punta, Marco M; Jennings, Victoria A VA; Melcher, Alan A AA; Lise, Stefano S

Publication Date: 2020

Variant appearance in text: N/A

PubMed Link: 33133066

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Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations.

Nature Communications

Brady, Samuel W SW; Liu, Yanling Y; Ma, Xiaotu X; Gout, Alexander M AM; Hagiwara, Kohei K; Zhou, Xin X; Wang, Jian J; Macias, Michael M; Chen, Xiaolong X; Easton, John J; Mulder, Heather L HL; Rusch, Michael M; Wang, Lu L; Nakitandwe, Joy J; Lei, Shaohua S; Davis, Eric M EM; Naranjo, Arlene A; Cheng, Cheng C; Maris, John M JM; Downing, James R JR; Cheung, Nai-Kong V NV; Hogarty, Michael D MD; Dyer, Michael A MA; Zhang, Jinghui J

Publication Date: 2020-10-14

Variant appearance in text: N/A

PubMed Link: 33056981

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Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports

Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O

Publication Date: 2020-10-13

Variant appearance in text: rs1057519934

PubMed Link: 33051506

Variant Present in the following documents:

• 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1

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Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer.

Genome Medicine

Shi, Ming-Jun MJ; Meng, Xiang-Yu XY; Fontugne, Jacqueline J; Chen, Chun-Long CL; Radvanyi, François F; Bernard-Pierrot, Isabelle I

Publication Date: 2020-09-28

Variant appearance in text: PIK3CA: 333G>C; K111N

PubMed Link: 32988402

Variant Present in the following documents:

• 13073_2020_781_MOESM2_ESM.xlsx, sheet 1
• 13073_2020_781_MOESM3_ESM.pdf

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Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.

Nature Communications

Zaidi, Syed H SH; Harrison, Tabitha A TA; Phipps, Amanda I AI; Steinfelder, Robert R; Trinh, Quang M QM; Qu, Conghui C; Banbury, Barbara L BL; Georgeson, Peter P; Grasso, Catherine S CS; Giannakis, Marios M; Adams, Jeremy B JB; Alwers, Elizabeth E; Amitay, Efrat L EL; Barfield, Richard T RT; Berndt, Sonja I SI; Borozan, Ivan I; Brenner, Hermann H; Brezina, Stefanie S; Buchanan, Daniel D DD; Cao, Yin Y; Chan, Andrew T AT; Chang-Claude, Jenny J; Connolly, Charles M CM; Drew, David A DA; Farris, Alton Brad AB; Figueiredo, Jane C JC; French, Amy J AJ; Fuchs, Charles S CS; Garraway, Levi A LA; Gruber, Steve S; Guinter, Mark A MA; Hamilton, Stanley R SR; Harlid, Sophia S; Heisler, Lawrence E LE; Hidaka, Akihisa A; Hopper, John L JL; Huang, Wen-Yi WY; Huyghe, Jeroen R JR; Jenkins, Mark A MA; Krzyzanowski, Paul M PM; Lemire, Mathieu M; Lin, Yi Y; Luo, Xuemei X; Mardis, Elaine R ER; McPherson, John D JD; Miller, Jessica K JK; Moreno, Victor V; Mu, Xinmeng Jasmine XJ; Nishihara, Reiko R; Papadopoulos, Nickolas N; Pasternack, Danielle D; Quist, Michael J MJ; Rafikova, Adilya A; Reid, Emma E G EEG; Shinbrot, Eve E; Shirts, Brian H BH; Stein, Lincoln D LD; Teney, Cherie D CD; Timms, Lee L; Um, Caroline Y CY; Van Guelpen, Bethany B; Van Tassel, Megan M; Wang, Xiaolong X; Wheeler, David A DA; Yung, Christina K CK; Hsu, Li L; Ogino, Shuji S; Gsur, Andrea A; Newcomb, Polly A PA; Gallinger, Steven S; Hoffmeister, Michael M; Campbell, Peter T PT; Thibodeau, Stephen N SN; Sun, Wei W; Hudson, Thomas J TJ; Peters, Ulrike U

Publication Date: 2020-07-20

Variant appearance in text: PIK3CA: K111N

PubMed Link: 32686686

Variant Present in the following documents:

• 41467_2020_17386_MOESM4_ESM.xlsx, sheet 1

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Proliferative Classification of Intracranially Injected HER2-positive Breast Cancer Cell Lines.

Cancers

Kuroiwa, Yuka Y; Nakayama, Jun J; Adachi, Chihiro C; Inoue, Takafumi T; Watanabe, Shinya S; Semba, Kentaro K

Publication Date: 2020-07-06

Variant appearance in text: PIK3CA: K111N

PubMed Link: 32640677

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• Main text

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Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Zervantonakis, Ioannis K IK; Poskus, Matthew D MD; Scott, Alexis L AL; Selfors, Laura M LM; Lin, Jia-Ren JR; Dillon, Deborah A DA; Pathania, Shailja S; Sorger, Peter K PK; Mills, Gordon B GB; Brugge, Joan S JS

Publication Date: 2020-07-14

Variant appearance in text: PI3K: K111N

PubMed Link: 32601199

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• Main text
• pnas.202000648.pdf

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mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.

Cell Reports

Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM

Publication Date: 2020-06-23

Variant appearance in text: PIK3CA: K111N

PubMed Link: 32579932

Variant Present in the following documents:

• mmc5.xlsx, sheet 3

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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids.

Cell

Koundouros, Nikos N; Karali, Evdoxia E; Tripp, Aurelien A; Valle, Adamo A; Inglese, Paolo P; Perry, Nicholas J S NJS; Magee, David J DJ; Anjomani Virmouni, Sara S; Elder, George A GA; Tyson, Adam L AL; Dória, Maria Luisa ML; van Weverwijk, Antoinette A; Soares, Renata F RF; Isacke, Clare M CM; Nicholson, Jeremy K JK; Glen, Robert C RC; Takats, Zoltan Z; Poulogiannis, George G

Publication Date: 2020-06-25

Variant appearance in text: PIK3CA: K111N

PubMed Link: 32559461

Variant Present in the following documents:

• mmc5.xlsx, sheet 1

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Phase and context shape the function of composite oncogenic mutations.

Nature

Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS

Publication Date: 2020-06

Variant appearance in text: PIK3CA: K111N

PubMed Link: 32461694

Variant Present in the following documents:

• NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx, sheet 2

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A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity.

British Journal Of Cancer

Kostaras, Eleftherios E; Kaserer, Teresa T; Lazaro, Glorianne G; Heuss, Sara Farrah SF; Hussain, Aasia A; Casado, Pedro P; Hayes, Angela A; Yandim, Cihangir C; Palaskas, Nicolaos N; Yu, Yi Y; Schwartz, Brian B; Raynaud, Florence F; Chung, Yuen-Li YL; Cutillas, Pedro R PR; Vivanco, Igor I

Publication Date: 2020-08

Variant appearance in text: PIK3CA: K111N

PubMed Link: 32439931

Variant Present in the following documents:

• 41416_2020_Article_889.pdf

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: PIK3CA: K111N

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

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Molecular Classification of Gastric Cancer among Alaska Native People.

Cancers

Martinson, Holly A HA; Mallari, Dominic D; Richter, Christine C; Wu, Tsung-Teh TT; Tiesinga, James J; Alberts, Steven R SR; Olnes, Matthew J MJ

Publication Date: 2020-01-13

Variant appearance in text: PIK3CA: K111N

PubMed Link: 31941061

Variant Present in the following documents:

• Main text

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Roles of TrkC Signaling in the Regulation of Tumorigenicity and Metastasis of Cancer.

Cancers

Jin, Wook W

Publication Date: 2020-01-08

Variant appearance in text: N/A

PubMed Link: 31936239

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Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology

Dong, Xiaobao X; Huang, Dandan D; Yi, Xianfu X; Zhang, Shijie S; Wang, Zhao Z; Yan, Bin B; Chung Sham, Pak P; Chen, Kexin K; Jun Li, Mulin M

Publication Date: 2020-01-07

Variant appearance in text: PIK3CA: 333G>C; K111N

PubMed Link: 31925297

Variant Present in the following documents:

• 42003_2019_736_MOESM13_ESM.xlsx, sheet 1
• 42003_2019_736_MOESM4_ESM.xlsx, sheet 1
• 42003_2019_736_MOESM3_ESM.xlsx, sheet 1
• 42003_2019_736_MOESM10_ESM.xlsx, sheet 1

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NOTCH and DNA repair pathways are more frequently targeted by genomic alterations in inflammatory than in non-inflammatory breast cancers.

Molecular Oncology

Bertucci, François F; Rypens, Charlotte C; Finetti, Pascal P; Guille, Arnaud A; Adélaïde, José J; Monneur, Audrey A; Carbuccia, Nadine N; Garnier, Séverine S; Dirix, Piet P; Gonçalves, Anthony A; Vermeulen, Peter P; Debeb, Bisrat G BG; Wang, Xiaoping X; Dirix, Luc L; Ueno, Naoto T NT; Viens, Patrice P; Cristofanilli, Massimo M; Chaffanet, Max M; Birnbaum, Daniel D; Van Laere, Steven S

Publication Date: 2020-03

Variant appearance in text: N/A

PubMed Link: 31854063

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Phase II, 2-stage, 2-arm, PIK3CA mutation stratified trial of MK-2206 in recurrent endometrial cancer.

International Journal Of Cancer

Myers, Andrea P AP; Konstantinopoulos, Panagiotis A PA; Barry, William T WT; Luo, Weixiu W; Broaddus, Russell R RR; Makker, Vicky V; Drapkin, Ronny R; Liu, Joyce J; Doyle, Austin A; Horowitz, Neil S NS; Meric-Bernstam, Funda F; Birrer, Michael M; Aghajanian, Carol C; Coleman, Robert L RL; Mills, Gordon B GB; Cantley, Lewis C LC; Matulonis, Ursula A UA; Westin, Shannon N SN

Publication Date: 2020-07-15

Variant appearance in text: PIK3CA: K111N

PubMed Link: 31714586

Variant Present in the following documents:

• Main text

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Pan-cancer whole-genome analyses of metastatic solid tumours.

Nature

Priestley, Peter P; Baber, Jonathan J; Lolkema, Martijn P MP; Steeghs, Neeltje N; de Bruijn, Ewart E; Shale, Charles C; Duyvesteyn, Korneel K; Haidari, Susan S; van Hoeck, Arne A; Onstenk, Wendy W; Roepman, Paul P; Voda, Mircea M; Bloemendal, Haiko J HJ; Tjan-Heijnen, Vivianne C G VCG; van Herpen, Carla M L CML; Labots, Mariette M; Witteveen, Petronella O PO; Smit, Egbert F EF; Sleijfer, Stefan S; Voest, Emile E EE; Cuppen, Edwin E

Publication Date: 2019-11

Variant appearance in text: N/A

PubMed Link: 31645765

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