Variant ID: 3-178936091-G-A

NM_006218.2(PIK3CA):c.1633G>A;(p.E545K)

This variant was identified in 2229 publications

View GRCh38 version.




Publications:


Combined exome and transcriptome sequencing of non-muscle-invasive bladder cancer: associations between genomic changes, expression subtypes, and clinical outcomes.

Genome Medicine
Goel, Anshita A; Ward, Douglas G DG; Noyvert, Boris B; Yu, Minghao M; Gordon, Naheema S NS; Abbotts, Ben B; Colbourne, John K JK; Kissane, Stephen S; James, Nicholas D ND; Zeegers, Maurice P MP; Cheng, Kar Keung KK; Cazier, Jean-Baptiste JB; Whalley, Celina M CM; Beggs, Andrew D AD; Palles, Claire C; Arnold, Roland R; Bryan, Richard T RT
Publication Date: 2022-06-03

Variant appearance in text: PIK3CA: 1633G>A; Glu545Lys; rs104886003
PubMed Link: 35655252
Variant Present in the following documents:
  • 13073_2022_1056_MOESM1_ESM.xlsx
View BVdb publication page



The genomic landscape of cholangiocarcinoma reveals the disruption of post-transcriptional modifiers.

Nature Communications
Zhang, Yaodong Y; Ma, Zijian Z; Li, Changxian C; Wang, Cheng C; Jiang, Wangjie W; Chang, Jiang J; Han, Sheng S; Lu, Zefa Z; Shao, Zicheng Z; Wang, Yirui Y; Wang, Hongwei H; Jiao, Chenyu C; Wang, Dong D; Wu, Xiaofeng X; Shen, Hongbing H; Wang, Xuehao X; Hu, Zhibin Z; Li, Xiangcheng X
Publication Date: 2022-06-01

Variant appearance in text: PIK3CA: 1633G>A; E545K
PubMed Link: 35650238
Variant Present in the following documents:
  • 41467_2022_30708_MOESM1_ESM.pdf
View BVdb publication page



Convergent evolution and multi-wave clonal invasion in H3 K27-altered diffuse midline gliomas treated with a PDGFR inhibitor.

Acta Neuropathologica Communications
Arunachalam, Sasi S; Szlachta, Karol K; Brady, Samuel W SW; Ma, Xiaotu X; Ju, Bensheng B; Shaner, Bridget B; Mulder, Heather L HL; Easton, John J; Raphael, Benjamin J BJ; Myers, Matthew M; Tinkle, Christopher C; Allen, Sariah J SJ; Orr, Brent A BA; Wetmore, Cynthia J CJ; Baker, Suzanne J SJ; Zhang, Jinghui J
Publication Date: 2022-05-31

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35642016
Variant Present in the following documents:
  • Main text
  • 40478_2022_1381_MOESM2_ESM.pdf
View BVdb publication page



Viral and Genomic Drivers of Squamous Cell Neoplasms Arising in the Lacrimal Drainage System.

Cancers
Ramberg, Ingvild I; Vieira, Filipe Garrett FG; Toft, Peter Bjerre PB; von Buchwald, Christian C; Heegaard, Steffen S
Publication Date: 2022-05-23

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35626161
Variant Present in the following documents:
  • Main text
  • cancers-14-02558.pdf
View BVdb publication page



Disentangling ERBB Signaling in Breast Cancer Subtypes-A Model-Based Analysis.

Cancers
Kemmer, Svenja S; Berdiel-Acer, Mireia M; Reinz, Eileen E; Sonntag, Johanna J; Tarade, Nooraldeen N; Bernhardt, Stephan S; Fehling-Kaschek, Mirjam M; Hasmann, Max M; Korf, Ulrike U; Wiemann, Stefan S; Timmer, Jens J
Publication Date: 2022-05-12

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35625984
Variant Present in the following documents:
  • Main text
  • cancers-14-02379.pdf
View BVdb publication page



Kinases on Double Duty: A Review of UniProtKB Annotated Bifunctionality within the Kinome.

Biomolecules
Rangwala, Aziz M AM; Mingione, Victoria R VR; Georghiou, George G; Seeliger, Markus A MA
Publication Date: 2022-05-11

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35625613
Variant Present in the following documents:
  • Main text
  • biomolecules-12-00685.pdf
View BVdb publication page



Histologic and Genotypic Characterization of Lung Cancer in the Inuit Population of the Eastern Canadian Arctic.

Current Oncology (Toronto, Ont.)
Goss, Glenwood D GD; Spaans, Johanna N JN; Huntsman, David D; Asmis, Timothy T; Andrews Wright, Natalie M NM; Duciaume, Marc M; Kaurah, Pardeep P; Miller, Ruth R RR; Banerji, Shantanu S; Sekhon, Harmanjatinder S HS; Gomes, Marcio M MM
Publication Date: 2022-04-29

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35621648
Variant Present in the following documents:
  • Main text
  • curroncol-29-00258.pdf
View BVdb publication page



PIK3CA mutations-mediated downregulation of circLHFPL2 inhibits colorectal cancer progression via upregulating PTEN.

Molecular Cancer
Chong, Xiaodan X; Chen, Jingde J; Zheng, Nanxin N; Zhou, Zhuqing Z; Hai, Yanan Y; Chen, Shiqing S; Zhang, Yu Y; Yu, Qingzhuo Q; Yu, Shijun S; Chen, Zhiqin Z; Bao, Wenfang W; Quan, Ming M; Chen, Zhe-Sheng ZS; Zhan, Yangyang Y; Gao, Yong Y
Publication Date: 2022-05-26

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35619132
Variant Present in the following documents:
  • Main text
  • 12943_2022_Article_1531.pdf
View BVdb publication page



ROBO1 p.E280* Loses the Inhibitory Effects on the Proliferation and Angiogenesis of Wild-Type ROBO1 in Cholangiocarcinoma by Interrupting SLIT2 Signal.

Frontiers In Oncology
Zhou, Tao T; Zhang, Yaodong Y; Chen, Yananlan Y; Shan, Jijun J; Wang, Jifei J; Wang, Yirui Y; Chang, Jiang J; Jiang, Wangjie W; Chen, Ruixiang R; Wang, Ziyi Z; Shi, Xiaoli X; Yu, Yue Y; Li, Changxian C; Li, Xiangcheng X
Publication Date: 2022

Variant appearance in text: PIK3CA: 1633G>A; E545K
PubMed Link: 35615148
Variant Present in the following documents:
  • DataSheet_1.xlsx
View BVdb publication page



Pyronaridine Protects against SARS-CoV-2 Infection in Mouse.

Acs Infectious Diseases
Puhl, Ana C AC; Gomes, Giovanni F GF; Damasceno, Samara S; Godoy, Andre S AS; Noske, Gabriela D GD; Nakamura, Aline M AM; Gawriljuk, Victor O VO; Fernandes, Rafaela S RS; Monakhova, Natalia N; Riabova, Olga O; Lane, Thomas R TR; Makarov, Vadim V; Veras, Flavio P FP; Batah, Sabrina S SS; Fabro, Alexandre T AT; Oliva, Glaucius G; Cunha, Fernando Q FQ; Alves-Filho, José C JC; Cunha, Thiago M TM; Ekins, Sean S
Publication Date: 2022-05-24

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35609344
Variant Present in the following documents:
  • id2c00091_si_001.pdf
View BVdb publication page



Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma.

Clinical And Translational Medicine
Xing, Hui H; Gao, Mengshi M; Wang, Yuxiang Y; Zhang, Xu X; Shi, Jiajie J; Wang, Xiang X; Liu, Xueling X; Ma, Qingyang Q; Kong, Xiangyin X; Yang, Chunhao C; Ding, Jian J; Meng, Linghua L
Publication Date: 2022-05

Variant appearance in text: PI3K: E545K
PubMed Link: 35604910
Variant Present in the following documents:
  • Main text
  • CTM2-12-e835.pdf
View BVdb publication page



Network rewiring, adaptive resistance and combating strategies in breast cancer.

Cancer Drug Resistance (Alhambra, Calif.)
Cremers, Constance Gaya CG; Nguyen, Lan K LK
Publication Date: 2019

Variant appearance in text: PI3K: E545K
PubMed Link: 35582276
Variant Present in the following documents:
  • cdr-2-1106.pdf
View BVdb publication page



Attribution of Cancer Origins to Endogenous, Exogenous, and Preventable Mutational Processes.

Molecular Biology And Evolution
Cannataro, Vincent L VL; Mandell, Jeffrey D JD; Townsend, Jeffrey P JP
Publication Date: 2022-05-03

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35580068
Variant Present in the following documents:
  • msac084.pdf
View BVdb publication page



XNAs: A Troubleshooter for Nucleic Acid Sensing.

Acs Omega
Mana, Tanushree T; Bhattacharya, Budhaditya B; Lahiri, Hiya H; Mukhopadhyay, Rupa R
Publication Date: 2022-05-10

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35571783
Variant Present in the following documents:
  • ao2c00581.pdf
View BVdb publication page



FGFR Fusions as an Acquired Resistance Mechanism Following Treatment with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR TKIs) and a Suggested Novel Target in Advanced Non-Small Cell Lung Cancer (aNSCLC).

Journal Of Clinical Medicine
Raphael, Ari A; Dudnik, Elizabeth E; Hershkovitz, Dov D; Jain, Suyog S; Olsen, Steve S; Soussan-Gutman, Lior L; Ben-Shitrit, Taly T; Dvir, Addie A; Nechushtan, Hovav H; Peled, Nir N; Onn, Amir A; Agbarya, Abed A; On Behalf Of The Israel Lung Cancer Group,
Publication Date: 2022-04-28

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35566609
Variant Present in the following documents:
  • jcm-11-02475.pdf
View BVdb publication page



Potential Biomarkers of Skin Melanoma Resistance to Targeted Therapy-Present State and Perspectives.

Cancers
Olbryt, Magdalena M
Publication Date: 2022-05-06

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35565444
Variant Present in the following documents:
  • cancers-14-02315.pdf
View BVdb publication page



CfDNA Measurement as a Diagnostic Tool for the Detection of Brain Somatic Mutations in Refractory Epilepsy.

International Journal Of Molecular Sciences
Mayo, Sonia S; Gómez-Manjón, Irene I; Fernández-Martínez, Francisco Javier FJ; Camacho, Ana A; Martínez, Francisco F; Benito-León, Julián J
Publication Date: 2022-04-28

Variant appearance in text: PIK3CA: 1633G>A
PubMed Link: 35563270
Variant Present in the following documents:
  • ijms-23-04879.pdf
View BVdb publication page



Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages.

Nature Communications
Ng, Charlotte K Y CKY; Dazert, Eva E; Boldanova, Tuyana T; Coto-Llerena, Mairene M; Nuciforo, Sandro S; Ercan, Caner C; Suslov, Aleksei A; Meier, Marie-Anne MA; Bock, Thomas T; Schmidt, Alexander A; Ketterer, Sylvia S; Wang, Xueya X; Wieland, Stefan S; Matter, Matthias S MS; Colombi, Marco M; Piscuoglio, Salvatore S; Terracciano, Luigi M LM; Hall, Michael N MN; Heim, Markus H MH
Publication Date: 2022-05-04

Variant appearance in text: PIK3CA: 1633G>A; Glu545Lys; rs104886003
PubMed Link: 35508466
Variant Present in the following documents:
  • 41467_2022_29960_MOESM12_ESM.xlsx
View BVdb publication page



Analytical and clinical validation of an amplicon-based next generation sequencing assay for ultrasensitive detection of circulating tumor DNA.

Plos One
Poh, Jonathan J; Ngeow, Kao Chin KC; Pek, Michelle M; Tan, Kian-Hin KH; Lim, Jing Shan JS; Chen, Hao H; Ong, Choon Kiat CK; Lim, Jing Quan JQ; Lim, Soon Thye ST; Lim, Chwee Ming CM; Goh, Boon Cher BC; Choudhury, Yukti Y
Publication Date: 2022

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35486650
Variant Present in the following documents:
  • pone.0267389.pdf
  • pone.0267389.s008.xlsx
View BVdb publication page



Distinct clinical and somatic mutational features of breast tumors with high-, low-, or non-expressing human epidermal growth factor receptor 2 status.

Bmc Medicine
Zhang, Guochun G; Ren, Chongyang C; Li, Cheukfai C; Wang, Yulei Y; Chen, Bo B; Wen, Lingzhu L; Jia, Minghan M; Li, Kai K; Mok, Hsiaopei H; Cao, Li L; Chen, Xiaoqing X; Lin, Jiali J; Wei, Guangnan G; Li, Yingzhi Y; Zhang, Yuchen Y; Balch, Charles M CM; Liao, Ning N
Publication Date: 2022-04-29

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35484593
Variant Present in the following documents:
  • 12916_2022_Article_2346.pdf
View BVdb publication page



Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.

Nature Medicine
Chandran, Smita S SS; Ma, Jiaqi J; Klatt, Martin G MG; Dündar, Friederike F; Bandlamudi, Chaitanya C; Razavi, Pedram P; Wen, Hannah Y HY; Weigelt, Britta B; Zumbo, Paul P; Fu, Si Ning SN; Banks, Lauren B LB; Yi, Fei F; Vercher, Enric E; Etxeberria, Inaki I; Bestman, Watchain D WD; Da Cruz Paula, Arnaud A; Aricescu, Ilinca S IS; Drilon, Alexander A; Betel, Doron D; Scheinberg, David A DA; Baker, Brian M BM; Klebanoff, Christopher A CA
Publication Date: 2022-04-28

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35484264
Variant Present in the following documents:
  • 41591_2022_Article_1786.pdf
View BVdb publication page



The utility of cerebrospinal fluid-derived cell-free DNA in molecular diagnostics for the PIK3CA-related megalencephaly-capillary malformation (MCAP) syndrome: a case report.

Cold Spring Harbor Molecular Case Studies
Chen, Wei-Liang WL; Pao, Emily E; Owens, James J; Glass, Ian I; Pritchard, Colin C; Shirts, Brain H BH; Lockwood, Christina C; Mirzaa, Ghayda M GM
Publication Date: 2022-04

Variant appearance in text: PIK3CA: 1633G>A
PubMed Link: 35483878
Variant Present in the following documents:
  • MCS006188Che.pdf
View BVdb publication page



Baseline Mutations and Up-Regulation of PI3K-AKT Pathway Serve as Potential Indicators of Lack of Response to Neoadjuvant Chemotherapy in Stage II/III Breast Cancer.

Frontiers In Oncology
Dong, Menghao M; Shan, Benjie B; Han, Xinghua X; Zhao, Xiaotian X; Wang, Fufeng F; Zhu, Liuqing L; Ou, Qiuxiang Q; Ma, Xiaopeng X; Pan, Yueyin Y
Publication Date: 2021

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35480699
Variant Present in the following documents:
  • fonc-11-784985.pdf
View BVdb publication page



Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Bmc Medical Genomics
Sobahy, Turki M TM; Tashkandi, Ghassan G; Bahussain, Donya D; Al-Harbi, Raneem R
Publication Date: 2022-04-25

Variant appearance in text: PIK3CA: 1633G>A
PubMed Link: 35468810
Variant Present in the following documents:
  • 12920_2022_1235_MOESM3_ESM.xlsx
  • 12920_2022_1235_MOESM2_ESM.xlsx
View BVdb publication page



Preclinical Models for Acquired Resistance to Third-Generation EGFR Inhibitors in NSCLC: Functional Studies and Drug Combinations Used to Overcome Resistance.

Frontiers In Oncology
Mahfoudhi, Emna E; Ricordel, Charles C; Lecuyer, Gwendoline G; Mouric, Cécile C; Lena, Hervé H; Pedeux, Rémy R
Publication Date: 2022

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35463360
Variant Present in the following documents:
  • fonc-12-853501.pdf
View BVdb publication page



Germline MBD4 deficiency causes a multi-tumor predisposition syndrome.

American Journal Of Human Genetics
Palles, Claire C; West, Hannah D HD; Chew, Edward E; Galavotti, Sara S; Flensburg, Christoffer C; Grolleman, Judith E JE; Jansen, Erik A M EAM; Curley, Helen H; Chegwidden, Laura L; Arbe-Barnes, Edward H EH; Lander, Nicola N; Truscott, Rebekah R; Pagan, Judith J; Bajel, Ashish A; Sherwood, Kitty K; Martin, Lynn L; Thomas, Huw H; Georgiou, Demetra D; Fostira, Florentia F; Goldberg, Yael Y; Adams, David J DJ; van der Biezen, Simone A M SAM; Christie, Michael M; Clendenning, Mark M; Thomas, Laura E LE; Deltas, Constantinos C; Dimovski, Aleksandar J AJ; Dymerska, Dagmara D; Lubinski, Jan J; Mahmood, Khalid K; van der Post, Rachel S RS; Sanders, Mathijs M; Weitz, Jürgen J; Taylor, Jenny C JC; Turnbull, Clare C; Vreede, Lilian L; van Wezel, Tom T; Whalley, Celina C; Arnedo-Pac, Claudia C; Caravagna, Giulio G; Cross, William W; Chubb, Daniel D; Frangou, Anna A; Gruber, Andreas J AJ; Kinnersley, Ben B; Noyvert, Boris B; Church, David D; Graham, Trevor T; Houlston, Richard R; Lopez-Bigas, Nuria N; Sottoriva, Andrea A; Wedge, David D; , ; , ; , ; Jenkins, Mark A MA; Kuiper, Roland P RP; Roberts, Andrew W AW; Cheadle, Jeremy P JP; Ligtenberg, Marjolijn J L MJL; Hoogerbrugge, Nicoline N; Koelzer, Viktor H VH; Rivas, Andres Dacal AD; Winship, Ingrid M IM; Ponte, Clara Ruiz CR; Buchanan, Daniel D DD; Power, Derek G DG; Green, Andrew A; Tomlinson, Ian P M IPM; Sampson, Julian R JR; Majewski, Ian J IJ; de Voer, Richarda M RM
Publication Date: 2022-04-20

Variant appearance in text: PIK3CA: 1633G>A; Glu545Lys
PubMed Link: 35460607
Variant Present in the following documents:
  • mmc2.xlsx
View BVdb publication page



Pediatric High Grade Glioma Classification Criteria and Molecular Features of a Case Series.

Genes
Buccoliero, Anna Maria AM; Giunti, Laura L; Moscardi, Selene S; Castiglione, Francesca F; Provenzano, Aldesia A; Sardi, Iacopo I; Scagnet, Mirko M; Genitori, Lorenzo L; Caporalini, Chiara C
Publication Date: 2022-03-31

Variant appearance in text: PIK3CA: 1633G>A; Glu545Lys
PubMed Link: 35456430
Variant Present in the following documents:
  • genes-13-00624.pdf
View BVdb publication page



Acquired Mechanisms of Resistance to Osimertinib-The Next Challenge.

Cancers
Ríos-Hoyo, Alejandro A; Moliner, Laura L; Arriola, Edurne E
Publication Date: 2022-04-12

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35454838
Variant Present in the following documents:
  • cancers-14-01931.pdf
View BVdb publication page



Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity.

Nature Communications
Shi, Xiaohan X; Li, Yunguang Y; Yuan, Qiuyue Q; Tang, Shijie S; Guo, Shiwei S; Zhang, Yehan Y; He, Juan J; Zhang, Xiaoyu X; Han, Ming M; Liu, Zhuang Z; Zhu, Yiqin Y; Gao, Suizhi S; Wang, Huan H; Xu, Xiongfei X; Zheng, Kailian K; Jing, Wei W; Chen, Luonan L; Wang, Yong Y; Jin, Gang G; Gao, Dong D
Publication Date: 2022-04-21

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35449156
Variant Present in the following documents:
  • 41467_2022_29857_MOESM5_ESM.xlsx
View BVdb publication page



5-Hydroxymethylcytosine (5hmC) at or near cancer mutation hot spots as potential targets for early cancer detection.

Bmc Research Notes
Lu, Michael J MJ; Lu, Yabin Y
Publication Date: 2022-04-21

Variant appearance in text: PIK3CA: 1633G>A; E545K
PubMed Link: 35449110
Variant Present in the following documents:
  • 13104_2022_Article_6028.pdf
View BVdb publication page



AKT mutant allele-specific activation dictates pharmacologic sensitivities.

Nature Communications
Shrestha Bhattarai, Tripti T; Shamu, Tambudzai T; Gorelick, Alexander N AN; Chang, Matthew T MT; Chakravarty, Debyani D; Gavrila, Elena I EI; Donoghue, Mark T A MTA; Gao, JianJong J; Patel, Swati S; Gao, Sizhi Paul SP; Reynolds, Margaret H MH; Phillips, Sarah M SM; Soumerai, Tara T; Abida, Wassim W; Hyman, David M DM; Schram, Alison M AM; Solit, David B DB; Smyth, Lillian M LM; Taylor, Barry S BS
Publication Date: 2022-04-19

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35440569
Variant Present in the following documents:
  • 41467_2022_29638_MOESM2_ESM.pdf
View BVdb publication page



Activated TAZ induces liver cancer in collaboration with EGFR/HER2 signaling pathways.

Bmc Cancer
Moon, Hyuk H; Park, Hyunjung H; Chae, Min Jee MJ; Choi, Hye Jin HJ; Kim, Do Young DY; Ro, Simon Weonsang SW
Publication Date: 2022-04-19

Variant appearance in text: PI3K: E545K
PubMed Link: 35439973
Variant Present in the following documents:
  • 12885_2022_Article_9516.pdf
View BVdb publication page



Ureteral metastasis of small cell lung cancer transformed from lung adenocarcinoma: A case report.

Thoracic Cancer
Wang, Yi Y; Li, Ji J; Luo, Lei L; Li, Xiaoliang X; Liu, Qingsong Q; Wang, Yan Y; Che, Guowei G; Xie, Xiaoyang X
Publication Date: 2022-04-18

Variant appearance in text: PIK3CA: Glu545Lys
PubMed Link: 35437882
Variant Present in the following documents:
  • Main text
  • TCA-13-1731.pdf
View BVdb publication page



The Potential Role of Genomic Signature in Stage II Relapsed Colorectal Cancer (CRC) Patients: A Mono-Institutional Study.

Cancer Management And Research
Roberto, Michela M; Arrivi, Giulia G; Pilozzi, Emanuela E; Montori, Andrea A; Balducci, Genoveffa G; Mercantini, Paolo P; Laghi, Andrea A; Ierinò, Debora D; Panebianco, Martina M; Marinelli, Daniele D; Tomao, Silverio S; Marchetti, Paolo P; Mazzuca, Federica F
Publication Date: 2022

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35418781
Variant Present in the following documents:
  • cmar-14-1353.pdf
View BVdb publication page



Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer.

Nature Communications
Hao, Yujun Y; He, Baoyu B; Wu, Liping L; Li, Yamu Y; Wang, Chao C; Wang, Ting T; Sun, Longci L; Zhang, Yanhua Y; Zhan, Yangyang Y; Zhao, Yiqing Y; Markowitz, Sanford S; Veigl, Martina M; Conlon, Ronald A RA; Wang, Zhenghe Z
Publication Date: 2022-04-13

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35418124
Variant Present in the following documents:
  • 41467_2022_Article_29585.pdf
  • 41467_2022_29585_MOESM1_ESM.pdf
  • 41467_2022_29585_MOESM7_ESM.xlsx
  • 41467_2022_29585_MOESM2_ESM.pdf
View BVdb publication page



TMT-Based Multiplexed Quantitation of N-Glycopeptides Reveals Glycoproteome Remodeling Induced by Oncogenic Mutations.

Acs Omega
Saraswat, Mayank M; Mangalaparthi, Kiran Kumar KK; Garapati, Kishore K; Pandey, Akhilesh A
Publication Date: 2022-04-05

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35415375
Variant Present in the following documents:
  • ao1c06970.pdf
View BVdb publication page



Gypenoside-Induced Apoptosis via the PI3K/AKT/mTOR Signaling Pathway in Bladder Cancer.

Biomed Research International
Li, Xiuming X; Liu, Hui H; Lv, Chengcheng C; Du, Jun J; Lian, Fangchao F; Zhang, Shouyi S; Wang, Zhiyong Z; Zeng, Yu Y
Publication Date: 2022

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35402614
Variant Present in the following documents:
  • BMRI2022-9304552.pdf
View BVdb publication page



PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?

Frontiers In Oncology
Peng, Yan Y; Wang, Yuanyuan Y; Zhou, Cheng C; Mei, Wuxuan W; Zeng, Changchun C
Publication Date: 2022

Variant appearance in text: PI3K: E545K
PubMed Link: 35402264
Variant Present in the following documents:
  • fonc-12-819128.pdf
View BVdb publication page



Clinicopathologic and Genomic Features in Triple-Negative Breast Cancer Between Special and No-Special Morphologic Pattern.

Frontiers In Oncology
Li, Ying-Zi YZ; Chen, Bo B; Lin, Xiao-Yi XY; Zhang, Guo-Chun GC; Lai, Jian-Guo JG; Li, Cheukfai C; Lin, Jia-Li JL; Guo, Li-Ping LP; Xiao, Wei-Kai WK; Mok, Hsiaopei H; Ren, Chong-Yang CY; Wen, Ling-Zhu LZ; Cao, Fang-Rong FR; Lin, Xin X; Qi, Xiao-Fang XF; Liu, Yang Y; Liao, Ning N
Publication Date: 2022

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35402236
Variant Present in the following documents:
  • fonc-12-830124.pdf
View BVdb publication page



PI3K/Akt/mTOR Signaling Pathway: Role in Esophageal Squamous Cell Carcinoma, Regulatory Mechanisms and Opportunities for Targeted Therapy.

Frontiers In Oncology
Luo, Qian Q; Du, Ruijuan R; Liu, Wenting W; Huang, Guojing G; Dong, Zigang Z; Li, Xiang X
Publication Date: 2022

Variant appearance in text: PIK3CA: Glu545lys
PubMed Link: 35392233
Variant Present in the following documents:
  • fonc-12-852383.pdf
View BVdb publication page



A Comprehensive Survey of Genomic Mutations in Breast Cancer Reveals Recurrent Neoantigens as Potential Therapeutic Targets.

Frontiers In Oncology
Zhou, Si S; Liu, Songming S; Zhao, Lijian L; Sun, Hai-Xi HX
Publication Date: 2022

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35387130
Variant Present in the following documents:
  • fonc-12-786438.pdf
  • Table_2.xlsx
View BVdb publication page



A molecular approach integrating genomic and DNA methylation profiling for tissue of origin identification in lung-specific cancer of unknown primary.

Journal Of Translational Medicine
Chen, Kaiyan K; Zhang, Fanrong F; Yu, Xiaoqing X; Huang, Zhiyu Z; Gong, Lei L; Xu, Yanjun Y; Li, Hui H; Yu, Sizhe S; Fan, Yun Y
Publication Date: 2022-04-05

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35382836
Variant Present in the following documents:
  • 12967_2022_Article_3362.pdf
View BVdb publication page



Downregulation of KRAB zinc finger proteins in 5-fluorouracil resistant colorectal cancer cells.

Bmc Cancer
Chauvin, Anaïs A; Bergeron, Danny D; Vencic, Jean J; Lévesque, Dominique D; Paquette, Benoit B; Scott, Michelle S MS; Boisvert, François-Michel FM
Publication Date: 2022-04-04

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35379199
Variant Present in the following documents:
  • 12885_2022_Article_9417.pdf
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Somatic activating BRAF variants cause isolated lymphatic malformations.

Hgg Advances
Zenner, Kaitlyn K; Jensen, Dana M DM; Dmyterko, Victoria V; Shivaram, Giridhar M GM; Myers, Candace T CT; Paschal, Cate R CR; Rudzinski, Erin R ER; Pham, Minh-Hang M MM; Cheng, V Chi VC; Manning, Scott C SC; Bly, Randall A RA; Ganti, Sheila S; Perkins, Jonathan A JA; Bennett, James T JT
Publication Date: 2022-04-14

Variant appearance in text: PIK3CA: 1633G>A
PubMed Link: 35373151
Variant Present in the following documents:
  • mmc1.pdf
  • main.pdf
  • mmc2.pdf
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A Custom DNA-Based NGS Panel for the Molecular Characterization of Patients With Diffuse Gliomas: Diagnostic and Therapeutic Applications.

Frontiers In Oncology
Tirrò, Elena E; Massimino, Michele M; Broggi, Giuseppe G; Romano, Chiara C; Minasi, Simone S; Gianno, Francesca F; Antonelli, Manila M; Motta, Gianmarco G; Certo, Francesco F; Altieri, Roberto R; Manzella, Livia L; Caltabiano, Rosario R; Barbagallo, Giuseppe Maria Vincenzo GMV; Buttarelli, Francesca Romana FR; Magro, Gaetano G; Giangaspero, Felice F; Vigneri, Paolo P
Publication Date: 2022

Variant appearance in text: PIK3CA: GLu545Lys
PubMed Link: 35372034
Variant Present in the following documents:
  • Table_4.xlsx
View BVdb publication page



Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors.

Breast Cancer Research : Bcr
Heynen, Guus J J E GJJE; Lisek, Kamil K; Vogel, Regina R; Wulf-Goldenberg, Annika A; Alcaniz, Joshua J; Montaudon, Elodie E; Marangoni, Elisabetta E; Birchmeier, Walter W
Publication Date: 2022-04-01

Variant appearance in text: PI3K: E545K
PubMed Link: 35365185
Variant Present in the following documents:
  • 13058_2022_Article_1521.pdf
  • 13058_2022_1521_MOESM1_ESM.pdf
View BVdb publication page



Clinical utility of comprehensive genomic profiling in Japan: Result of PROFILE-F study.

Plos One
Aoyagi, Yasuko Y; Kano, Yoshihito Y; Tohyama, Kohki K; Matsudera, Shotaro S; Kumaki, Yuichi Y; Takahashi, Kenta K; Mitsumura, Takahiro T; Harada, Yohei Y; Sato, Akemi A; Nakamura, Hideaki H; Sueoka, Eisaburo E; Aragane, Naoko N; Kimura, Koichiro K; Onishi, Iichiro I; Takemoto, Akira A; Akahoshi, Keiichi K; Ono, Hiroaki H; Ishikawa, Toshiaki T; Tokunaga, Masanori M; Nakagawa, Tsuyoshi T; Oshima, Noriko N; Nakamura, Reiko R; Takagi, Masatoshi M; Asakage, Takahiro T; Uetake, Hiroyuki H; Tanabe, Minoru M; Miyake, Satoshi S; Kinugasa, Yusuke Y; Ikeda, Sadakatsu S
Publication Date: 2022

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35358259
Variant Present in the following documents:
  • pone.0266112.pdf
  • pone.0266112.s001.xlsx
View BVdb publication page



PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.

Jco Precision Oncology
Rasti, Aryana R AR; Guimaraes-Young, Amy A; Datko, Farrah F; Borges, Virginia F VF; Aisner, Dara L DL; Shagisultanova, Elena E
Publication Date: 2022-03

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35357905
Variant Present in the following documents:
  • po-6-e2100370.pdf
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Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα.

Journal Of The American Chemical Society
Borsari, Chiara C; Keles, Erhan E; McPhail, Jacob A JA; Schaefer, Alexander A; Sriramaratnam, Rohitha R; Goch, Wojciech W; Schaefer, Thorsten T; De Pascale, Martina M; Bal, Wojciech W; Gstaiger, Matthias M; Burke, John E JE; Wymann, Matthias P MP
Publication Date: 2022-03-30

Variant appearance in text: PIK3CA: Glu545Lys
PubMed Link: 35353516
Variant Present in the following documents:
  • ja1c13568.pdf
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MET Exon 14 Splice-Site Mutations Preferentially Activate KRAS Signaling to Drive Tumourigenesis.

Cancers
Lu, Daniel D; Nagelberg, Amy A; Chow, Justine Lm JL; Chen, Yankuan T YT; Michalchuk, Quentin Q; Somwar, Romel R; Lockwood, William W WW
Publication Date: 2022-03-08

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35326531
Variant Present in the following documents:
  • cancers-14-01378.pdf
View BVdb publication page



Urothelial Bladder Carcinomas with High Tumor Mutation Burden Have a Better Prognosis and Targetable Molecular Defects beyond Immunotherapies.

Current Oncology (Toronto, Ont.)
Voutsadakis, Ioannis A IA
Publication Date: 2022-02-24

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35323317
Variant Present in the following documents:
  • curroncol-29-00117.pdf
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Clinical significance of molecular subtypes of gastrointestinal tract adenocarcinoma.

World Journal Of Gastrointestinal Oncology
Ignatova, Ekaterina Olegovna EO; Kozlov, Evgenii E; Ivanov, Maxim M; Mileyko, Vladislav V; Menshikova, Sofia S; Sun, Henian H; Fedyanin, Mikhail M; Tryakin, Alexey A; Stilidi, Ivan I
Publication Date: 2022-03-15

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35321271
Variant Present in the following documents:
  • WJGO-14-628.pdf
View BVdb publication page



AKT1 and PIK3CA activating mutations in Moroccan bladder cancer patients´ biopsies and matched urine.

The Pan African Medical Journal
El Ahanidi, Hajar H; El Azzouzi, Meryem M; Arrouchi, Housna H; Alaoui, Chaimae Hafidi CH; Tetou, Mohammed M; Bensaid, Mounia M; Oukabli, Mohamed M; Ameur, Ahmed A; Al Bouzidi, Abderrahmane A; El Mzibri, Mohammed M; Attaleb, Mohammed M
Publication Date: 2022

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35317488
Variant Present in the following documents:
  • PAMJ-41-59.pdf
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Bacillus Calmette-Guérin Treatment Changes the Tumor Microenvironment of Non-Muscle-Invasive Bladder Cancer.

Frontiers In Oncology
Su, Fei F; Liu, Ming M; Zhang, Wei W; Tang, Min M; Zhang, Jinsong J; Li, Hexin H; Zou, Lihui L; Zhang, Rui R; Liu, Yudong Y; Li, Lin L; Ma, Jie J; Zhang, Yaqun Y; Chen, Meng M; Xiao, Fei F
Publication Date: 2022

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35311085
Variant Present in the following documents:
  • Table_1.xlsx
View BVdb publication page



PEAC: An Ultrasensitive and Cost-Effective MRD Detection System in Non-small Cell Lung Cancer Using Plasma Specimen.

Frontiers In Medicine
Xu, Jianping J; Pu, Yue Y; Lin, Rui R; Xiao, Shanshan S; Fu, Yingxue Y; Wang, Tao T
Publication Date: 2022

Variant appearance in text: PIK3CA: 1633G>A; E545K
PubMed Link: 35308511
Variant Present in the following documents:
  • fmed-09-822200.pdf
View BVdb publication page



Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer.

Molecular Biomedicine
Ruan, Hang H; Leibowitz, Brian J BJ; Peng, Yingpeng Y; Shen, Lin L; Chen, Lujia L; Kuang, Charlie C; Schoen, Robert E RE; Lu, Xinghua X; Zhang, Lin L; Yu, Jian J
Publication Date: 2022-03-21

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35307764
Variant Present in the following documents:
  • 43556_2022_70_MOESM1_ESM.pdf
View BVdb publication page



Dynamic changes in gene alterations during chemotherapy in metastatic castrate resistant prostate cancer.

Scientific Reports
Tan, Winston W; Zheng, Tiantian T; Wang, Amy A; Roacho, Joanna J; Thao, Seng S; Du, Pan P; Jia, Shidong S; Yu, Jianjun J; King, Bonnie L BL; Kohli, Manish M
Publication Date: 2022-03-18

Variant appearance in text: PIK3CA: 1633G>A; Glu545Lys
PubMed Link: 35304525
Variant Present in the following documents:
  • 41598_2022_8520_MOESM2_ESM.xlsx
View BVdb publication page



The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers.

Nature Communications
Rosen, Ezra Y EY; Won, Helen H HH; Zheng, Youyun Y; Cocco, Emiliano E; Selcuklu, Duygu D; Gong, Yixiao Y; Friedman, Noah D ND; de Bruijn, Ino I; Sumer, Onur O; Bielski, Craig M CM; Savin, Casey C; Bourque, Caitlin C; Falcon, Christina C; Clarke, Nikeysha N; Jing, Xiaohong X; Meng, Fanli F; Zimel, Catherine C; Shifman, Sophie S; Kittane, Srusthi S; Wu, Fan F; Ladanyi, Marc M; Ebata, Kevin K; Kherani, Jennifer J; Brandhuber, Barbara J BJ; Fagin, James J; Sherman, Eric J EJ; Rekhtman, Natasha N; Berger, Michael F MF; Scaltriti, Maurizio M; Hyman, David M DM; Taylor, Barry S BS; Drilon, Alexander A
Publication Date: 2022-03-18

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35304457
Variant Present in the following documents:
  • 41467_2022_28848_MOESM1_ESM.pdf
View BVdb publication page



p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases.

Nature Communications
Ni, Jing J; Kabraji, Sheheryar S; Xie, Shaozhen S; Wang, Yanzhi Y; Pan, Peichen P; He, Xiaofang X; Liu, Zongming Z; Leone, Jose Palbo JP; Long, Henry W HW; Brown, Myles A MA; Winer, Eric P EP; Dillon, Deborah A R DAR; Lin, Nancy U NU; Zhao, Jean J JJ
Publication Date: 2022-03-18

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35304445
Variant Present in the following documents:
  • 41467_2022_29081_MOESM3_ESM.xlsx
View BVdb publication page



Clinical and analytical validation of FoundationOne®CDx, a comprehensive genomic profiling assay for solid tumors.

Plos One
Milbury, Coren A CA; Creeden, James J; Yip, Wai-Ki WK; Smith, David L DL; Pattani, Varun V; Maxwell, Kristi K; Sawchyn, Bethany B; Gjoerup, Ole O; Meng, Wei W; Skoletsky, Joel J; Concepcion, Alvin D AD; Tang, Yanhua Y; Bai, Xiaobo X; Dewal, Ninad N; Ma, Pei P; Bailey, Shannon T ST; Thornton, James J; Pavlick, Dean C DC; Frampton, Garrett M GM; Lieber, Daniel D; White, Jared J; Burns, Christine C; Vietz, Christine C
Publication Date: 2022

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35294956
Variant Present in the following documents:
  • pone.0264138.pdf
View BVdb publication page



Perioperative Circulating Tumor DNA Enables Identification of Patients with Poor Prognosis in Upper Tract Urothelial Carcinoma.

Cancer Science
Nakano, Kosuke K; Koh, Yoko Y; Yamamichi, Gaku G; Yumiba, Satoru S; Tomiyama, Eisuke E; Matsushita, Makoto M; Hayashi, Yujiro Y; Wang, Cong C; Ishizuya, Yu Y; Yamamoto, Yoshiyuki Y; Kato, Taigo T; Hatano, Koji K; Kawashima, Atsunari A; Ujike, Takeshi T; Fujita, Kazutoshi K; Kiyotani, Kazuma K; Katayama, Kotoe K; Yamaguchi, Rui R; Imoto, Seiya S; Imamura, Ryoichi R; Nonomura, Norio N; Uemura, Motohide M
Publication Date: 2022-03-16

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35293110
Variant Present in the following documents:
  • CAS-113-1830-s004.xlsx
  • CAS-113-1830.pdf
View BVdb publication page



Genetics and Epigenetics of Parathyroid Carcinoma.

Frontiers In Endocrinology
Marini, Francesca F; Giusti, Francesca F; Palmini, Gaia G; Perigli, Giuliano G; Santoro, Roberto R; Brandi, Maria Luisa ML
Publication Date: 2022

Variant appearance in text: PIK3CA: Glu545Lys
PubMed Link: 35282432
Variant Present in the following documents:
  • fendo-13-834362.pdf
View BVdb publication page



Circ-ZEB1 promotes PIK3CA expression by silencing miR-199a-3p and affects the proliferation and apoptosis of hepatocellular carcinoma.

Molecular Cancer
Liu, Weiwei W; Zheng, Lu L; Zhang, Rongguiyi R; Hou, Ping P; Wang, Jiakun J; Wu, Linquan L; Li, Jing J
Publication Date: 2022-03-11

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35277182
Variant Present in the following documents:
  • 12943_2022_Article_1529.pdf
View BVdb publication page



Circulating Tumor DNA Mutations in Progressive Gastrointestinal Stromal Tumors Identify Biomarkers of Treatment Resistance and Uncover Potential Therapeutic Strategies.

Frontiers In Oncology
Ko, Tun Kiat TK; Lee, Elizabeth E; Ng, Cedric Chuan-Young CC; Yang, Valerie Shiwen VS; Farid, Mohamad M; Teh, Bin Tean BT; Chan, Jason Yongsheng JY; Somasundaram, Nagavalli N
Publication Date: 2022

Variant appearance in text: PIK3CA: 1633G>A
PubMed Link: 35273917
Variant Present in the following documents:
  • fonc-12-840843.pdf
View BVdb publication page



The Landscape of Actionable Genomic Alterations by Next-Generation Sequencing in Tumor Tissue Versus Circulating Tumor DNA in Chinese Patients With Non-Small Cell Lung Cancer.

Frontiers In Oncology
Cai, Jun J; Jiang, Huihui H; Li, Shuqing S; Yan, Xiaoxia X; Wang, Meng M; Li, Na N; Zhu, Cuimin C; Dong, Hui H; Wang, Dongjuan D; Xu, Yue Y; Xie, Hui H; Wu, Shouxin S; Lou, Jingwei J; Zhao, Jiangman J; Li, Qingshan Q
Publication Date: 2021

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35273907
Variant Present in the following documents:
  • Table_7.xlsx
  • fonc-11-751106.pdf
View BVdb publication page



Clinical and genomic features of Chinese lung cancer patients with germline mutations.

Nature Communications
Peng, Wenying W; Li, Bin B; Li, Jin J; Chang, Lianpeng L; Bai, Jing J; Yi, Yuting Y; Chen, Rongrong R; Zhang, Yanyan Y; Chen, Chen C; Pu, Xingxiang X; Jiang, Meilin M; Li, Jia J; Zhong, Rui R; Xu, Fang F; Chen, Bolin B; Xu, Li L; Wang, Ning N; Huan, Jiaojiao J; Dai, Pingping P; Guan, Yanfang Y; Yang, Ling L; Xia, Xuefeng X; Yi, Xin X; Wang, Jiayin J; Yu, Fenglei F; Wu, Lin L
Publication Date: 2022-03-10

Variant appearance in text: PIK3CA: 1633G>A; E545K
PubMed Link: 35273153
Variant Present in the following documents:
  • 41467_2022_28840_MOESM7_ESM.xlsx
View BVdb publication page



PIK3CA Gene Mutations in HNSCC: Systematic Review and Correlations with HPV Status and Patient Survival.

Cancers
Cochicho, Daniela D; Esteves, Susana S; Rito, Miguel M; Silva, Fernanda F; Martins, Luís L; Montalvão, Pedro P; Cunha, Mário M; Magalhães, Miguel M; Gil da Costa, Rui M RM; Felix, Ana A
Publication Date: 2022-03-02

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35267596
Variant Present in the following documents:
  • cancers-14-01286.pdf
View BVdb publication page



Evaluation of the Clinical Utility of Genomic Profiling to Inform Selection of Clinical Trial Therapy in Salivary Gland Cancer.

Cancers
Rack, Samuel S; Feeney, Laura L; Hapuarachi, Brindley B; Adderley, Helen H; Woodhouse, Laura L; Betts, Guy G; Burghel, George J GJ; Harrington, Kevin J KJ; Metcalf, Robert R
Publication Date: 2022-02-23

Variant appearance in text: PIK3CA: 1633G>A
PubMed Link: 35267442
Variant Present in the following documents:
  • cancers-14-01133.pdf
View BVdb publication page



The impact of whole genome and transcriptome analysis (WGTA) on predictive biomarker discovery and diagnostic accuracy of advanced malignancies.

The Journal Of Pathology. Clinical Research
Tessier-Cloutier, Basile B; Grewal, Jasleen K JK; Jones, Martin R MR; Pleasance, Erin E; Shen, Yaoqing Y; Cai, Ellen E; Dunham, Chris C; Hoang, Lynn L; Horst, Basil B; Huntsman, David G DG; Ionescu, Diana D; Karnezis, Anthony N AN; Lee, Anna F AF; Lee, Cheng Han CH; Lee, Tae Hoon TH; Twa, David Dw DD; Mungall, Andrew J AJ; Mungall, Karen K; Naso, Julia R JR; Ng, Tony T; Schaeffer, David F DF; Sheffield, Brandon S BS; Skinnider, Brian B; Smith, Tyler T; Williamson, Laura L; Zhong, Ellia E; Regier, Dean A DA; Laskin, Janessa J; Marra, Marco A MA; Gilks, C Blake CB; Jones, Steven Jm SJ; Yip, Stephen S
Publication Date: 2022-03-08

Variant appearance in text: PIK3CA: E545K; rs104886003
PubMed Link: 35257510
Variant Present in the following documents:
  • CJP2-8-395-s002.xlsx
View BVdb publication page



Molecular landscape of osimertinib resistance in patients and patient-derived preclinical models.

Therapeutic Advances In Medical Oncology
Lim, Sun Min SM; Yang, San-Duk SD; Lim, Sangbin S; Heo, Seong Gu SG; Daniel, Stetson S; Markovets, Aleksandra A; Minoo, Rafati R; Pyo, Kyoung-Ho KH; Yun, Mi Ran MR; Hong, Min Hee MH; Kim, Hye Ryun HR; Cho, Byoung Chul BC
Publication Date: 2022

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35251316
Variant Present in the following documents:
  • 10.1177_17588359221079125.pdf
View BVdb publication page



The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer
Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J
Publication Date: 2022-02

Variant appearance in text: PIK3CA: Glu545Lys
PubMed Link: 35221333
Variant Present in the following documents:
  • 43018_2022_332_MOESM3_ESM.xlsx
View BVdb publication page



Neoantigen: A Promising Target for the Immunotherapy of Colorectal Cancer.

Disease Markers
Zheng, Yue Y; Fu, Yang Y; Wang, Pei-Pei PP; Ding, Zhen-Yu ZY
Publication Date: 2022

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35211210
Variant Present in the following documents:
  • DM2022-8270305.pdf
View BVdb publication page



Frequency of PIK3CA mutations in different subsites of head and neck squamous cell carcinoma in southern Thailand.

Journal Of Pathology And Translational Medicine
Dechaphunkul, Arunee A; Thongwatchara, Phatcharaporn P; Thongsuksai, Paramee P; Dechaphunkul, Tanadech T; Geater, Sarayut Lucien SL
Publication Date: 2022-02-28

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35209701
Variant Present in the following documents:
  • Main text
  • jptm-2022-01-04.pdf
View BVdb publication page



Characterization of the Genomic Landscape in Cervical Cancer by Next Generation Sequencing.

Genes
Qiu, Ling L; Feng, Hao H; Yu, Hailin H; Li, Ming M; You, Yana Y; Zhu, Shurong S; Yang, Wenting W; Jiang, Hua H; Wu, Xin X
Publication Date: 2022-01-31

Variant appearance in text: PIK3CA: 1633G>A
PubMed Link: 35205332
Variant Present in the following documents:
  • genes-13-00287.pdf
View BVdb publication page



A Prediction Model for Tumor Recurrence in Stage II-III Colorectal Cancer Patients: From a Machine Learning Model to Genomic Profiling.

Biomedicines
Chen, Po-Chuan PC; Yeh, Yu-Min YM; Lin, Bo-Wen BW; Chan, Ren-Hao RH; Su, Pei-Fang PF; Liu, Yi-Chia YC; Lee, Chung-Ta CT; Chen, Shang-Hung SH; Lin, Peng-Chan PC
Publication Date: 2022-02-01

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35203549
Variant Present in the following documents:
  • biomedicines-10-00340.pdf
View BVdb publication page



Rapid Multiplex Strip Test for the Detection of Circulating Tumor DNA Mutations for Liquid Biopsy Applications.

Biosensors
Kalligosfyri, Panagiota M PM; Nikou, Sofia S; Karteri, Sofia S; Kalofonos, Haralabos P HP; Bravou, Vasiliki V; Kalogianni, Despina P DP
Publication Date: 2022-02-04

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35200357
Variant Present in the following documents:
  • biosensors-12-00097.pdf
View BVdb publication page



Introduction and expression of PIK3CAE545K in a papillary thyroid cancer BRAFV600E cell line leads to a dedifferentiated aggressive phenotype.

Journal Of Otolaryngology - Head & Neck Surgery = Le Journal D'Oto-Rhino-Laryngologie Et De Chirurgie Cervico-Faciale
Pinto, Nicole N; Ruicci, Kara M KM; Khan, Mohammed Imran MI; Shaikh, Mushfiq Hassan MH; Zeng, Yu Fan Peter YFP; Yoo, John J; Fung, Kevin K; MacNeil, S Danielle SD; Mendez, Adrian A; Mymryk, Joe S JS; Barrett, John W JW; Boutros, Paul C PC; Nichols, Anthony C AC
Publication Date: 2022-02-22

Variant appearance in text: PIK3CA: E545K
PubMed Link: 35193694
Variant Present in the following documents:
  • 40463_2022_558_MOESM1_ESM.pdf
  • 40463_2022_Article_558.pdf
View BVdb publication page