Blood tumor mutational burden and dynamic changes in circulating tumor DNA predict response to pembrolizumab treatment in advanced non-small cell lung cancer.
Translational Lung Cancer Research
Stensgaard, Simone S; Thomsen, Astrid A; Helstrup, Sofie S; Meldgaard, Peter P; Sorensen, Boe S BS
Publication Date: 2023-05-31
Variant appearance in text: KIT: 2447A>T; Asp816Val
Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway.
Nature Communications
González, Lorena L; Díaz, Lucía L; Pous, Joan J; Baginski, Blazej B; Duran-Corbera, Anna A; Scarpa, Margherita M; Brun-Heath, Isabelle I; Igea, Ana A; Martin-Malpartida, Pau P; Ruiz, Lidia L; Pallara, Chiara C; Esguerra, Mauricio M; Colizzi, Francesco F; Mayor-Ruiz, Cristina C; Biondi, Ricardo M RM; Soliva, Robert R; Macias, Maria J MJ; Orozco, Modesto M; Nebreda, Angel R AR
Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.
Journal Of Medicinal Chemistry
Harnden, Alice C AC; Davis, Owen A OA; Box, Gary M GM; Hayes, Angela A; Johnson, Louise D LD; Henley, Alan T AT; de Haven Brandon, Alexis K AK; Valenti, Melanie M; Cheung, Kwai-Ming J KJ; Brennan, Alfie A; Huckvale, Rosemary R; Pierrat, Olivier A OA; Talbot, Rachel R; Bright, Michael D MD; Akpinar, Hafize Aysin HA; Miller, Daniel S J DSJ; Tarantino, Dalia D; Gowan, Sharon S; de Klerk, Selby S; McAndrew, Peter Craig PC; Le Bihan, Yann-Vaï YV; Meniconi, Mirco M; Burke, Rosemary R; Kirkin, Vladimir V; van Montfort, Rob L M RLM; Raynaud, Florence I FI; Rossanese, Olivia W OW; Bellenie, Benjamin R BR; Hoelder, Swen S
Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.
Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
Somatic mutation detection and KRAS amplification in testicular germ cell tumors.
Frontiers In Oncology
Cabral, Eduardo R M ERM; Pacanhella, Marilia F MF; Lengert, Andre V H AVH; Dos Reis, Mariana B MB; Leal, Leticia F LF; de Lima, Marcos A MA; da Silva, Aline L V ALV; Pinto, Icaro A IA; Reis, Rui M RM; Pinto, Mariana T MT; Cárcano, Flavio M FM
Deep genomic characterization highlights complexities and prognostic markers of pediatric acute myeloid leukemia.
Communications Biology
Cheng, Chi-Keung CK; Yung, Yuk-Lin YL; Chan, Hoi-Yun HY; Leung, Kam-Tong KT; Chan, Kathy Y Y KYY; Leung, Alex W K AWK; Cheng, Frankie W T FWT; Li, Chi-Kong CK; Wan, Thomas S K TSK; Luo, Xi X; Pitts, Herbert-Augustus HA; Cheung, Joyce S JS; Chan, Natalie P H NPH; Ng, Margaret H L MHL
Publication Date: 2023-03-31
Variant appearance in text: KIT: 2447A>T; D816V; rs121913507
Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy.
The Journal Of Clinical Investigation
Russell, Alan J AJ; DuVall, Mike M; Barthel, Benjamin B; Qian, Ying Y; Peter, Angela K AK; Newell-Stamper, Breanne L BL; Hunt, Kevin K; Lehman, Sarah J SJ; Madden, Molly R MR; Schlachter, Stephen T ST; Robertson, Benjamin D BD; Van Deusen, Ashleigh A; Rodriguez, Hector M HM; Vera, Carlos D CD; Su, Yu Y; Claflin, Dennis R DR; Brooks, Susan V SV; Nghiem, Peter P PP; Rutledge, Alexis A; Juehne, Twlya I TI; Yu, Jinsheng J; Barton, Elisabeth R ER; Luo, Yangyi E YE; Patsalos, Andreas A; Nagy, Laszlo L; Sweeney, H Lee HL; Leinwand, Leslie A LA; Koch, Kevin K
Neuropsychiatric Adverse Drug Reactions with Tyrosine Kinase Inhibitors in Gastrointestinal Stromal Tumors: An Analysis from the European Spontaneous Adverse Event Reporting System.
Cancers
Barbieri, Maria Antonietta MA; Sorbara, Emanuela Elisa EE; Russo, Giulia G; Cicala, Giuseppe G; Franchina, Tindara T; Santarpia, Mariacarmela M; Silvestris, Nicola N; Spina, Edoardo E
Shields, Alan L AL; Taylor, Fiona F; Lamoureux, Roger E RE; Padilla, Brad B; Severson, Kas K; Green, Tanya T; Boral, Anthony L AL; Akin, Cem C; Siebenhaar, Frank F; Mar, Brenton B
Engraftment in NSGSCF mice correlates with the WHO category and prognosis in systemic mastocytosis.
Leukemia
Willmann, Michael M; Peter, Barbara B; Slavnitsch, Katharina K; Berger, Daniela D; Witzeneder, Nadine N; Stefanzl, Gabriele G; Eisenwort, Gregor G; Ivanov, Daniel D; Sadovnik, Irina I; Hadzijusufovic, Emir E; Greiner, Georg G; Bernthaler, Tina T; Hoermann, Gregor G; Dahlhoff, Maik M; Rülicke, Thomas T; Valent, Peter P
Investigation of the anti-tumor mechanism of tirabrutinib, a highly selective Bruton's tyrosine kinase inhibitor, by phosphoproteomics and transcriptomics.
SETD2 non genomic loss of function in advanced systemic mastocytosis is mediated by an Aurora kinase A/MDM2 axis and can be therapeutically targeted.
Biomarker Research
Mancini, Manuela M; Monaldi, Cecilia C; De Santis, Sara S; Papayannidis, Cristina C; Rondoni, Michela M; Sartor, Chiara C; Bruno, Samantha S; Pagano, Livio L; Criscuolo, Marianna M; Zanotti, Roberta R; Bonifacio, Massimiliano M; Tosi, Patrizia P; Arock, Michel M; Valent, Peter P; Cavo, Michele M; Soverini, Simona S
Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer.
Nature Communications
Hong, Lingzhi L; Aminu, Muhammad M; Li, Shenduo S; Lu, Xuetao X; Petranovic, Milena M; Saad, Maliazurina B MB; Chen, Pingjun P; Qin, Kang K; Varghese, Susan S; Rinsurongkawong, Waree W; Rinsurongkawong, Vadeerat V; Spelman, Amy A; Elamin, Yasir Y YY; Negrao, Marcelo V MV; Skoulidis, Ferdinandos F; Gay, Carl M CM; Cascone, Tina T; Gandhi, Saumil J SJ; Lin, Steven H SH; Lee, Percy P PP; Carter, Brett W BW; Wu, Carol C CC; Antonoff, Mara B MB; Sepesi, Boris B; Lewis, Jeff J; Gibbons, Don L DL; Vaporciyan, Ara A AA; Le, Xiuning X; Jack Lee, J J; Roy-Chowdhuri, Sinchita S; Routbort, Mark J MJ; Gainor, Justin F JF; Heymach, John V JV; Lou, Yanyan Y; Wu, Jia J; Zhang, Jianjun J; Vokes, Natalie I NI