BRAF c.1789C>G ;(p.L597V)

Variant ID: 7-140453146-G-C

NM_004333.4(BRAF):c.1789C>G;(p.L597V)

This variant was identified in 154 publications

View GRCh38 version.




Publications:


An integrated model for predicting KRAS dependency.

Plos Computational Biology
Tsai, Yihsuan S YS; Chareddy, Yogitha S YS; Price, Brandon A BA; Parker, Joel S JS; Pecot, Chad V CV
Publication Date: 2023-05-04

Variant appearance in text: BRAF: L597V
PubMed Link: 37141389
Variant Present in the following documents:
  • Main text
  • pcbi.1011095.pdf
View BVdb publication page



Pathogenic genomic alterations in Chinese pancreatic cancer patients and their therapeutical implications.

Cancer Medicine
Zhao, Zhiming Z; Li, Xiaomo X; Wang, Fei F; Xu, Yong Y; Liu, Si S; Han, Quanli Q; Yang, Zhiying Z; Huang, Weiwei W; Yin, Zhuzeng Z; Liu, Qu Q; Tan, Haidong H; Ma, Tonghui T; Si, Shuang S; Huang, Jia J; Yuan, Hongling H; Li, Wei W; Liu, Rong R
Publication Date: 2023-03-31

Variant appearance in text: BRAF: L597V
PubMed Link: 36999792
Variant Present in the following documents:
  • CAM4-12-11672.pdf
View BVdb publication page



Recapitulating thyroid cancer histotypes through engineering embryonic stem cells.

Nature Communications
Veschi, Veronica V; Turdo, Alice A; Modica, Chiara C; Verona, Francesco F; Di Franco, Simone S; Gaggianesi, Miriam M; Tirrò, Elena E; Di Bella, Sebastiano S; Iacono, Melania Lo ML; Pantina, Vincenzo Davide VD; Porcelli, Gaetana G; Mangiapane, Laura Rosa LR; Bianca, Paola P; Rizzo, Aroldo A; Sciacca, Elisabetta E; Pillitteri, Irene I; Vella, Veronica V; Belfiore, Antonino A; Bongiorno, Maria Rita MR; Pistone, Giuseppe G; Memeo, Lorenzo L; Colarossi, Lorenzo L; Giuffrida, Dario D; Colarossi, Cristina C; Vigneri, Paolo P; Todaro, Matilde M; Stassi, Giorgio G
Publication Date: 2023-03-11

Variant appearance in text: BRAF: L597V
PubMed Link: 36906579
Variant Present in the following documents:
  • 41467_2023_36922_MOESM4_ESM.xls, sheet 2
View BVdb publication page



Association of BRAF Variants With Disease Characteristics, Prognosis, and Targeted Therapy Response in Intrahepatic Cholangiocarcinoma.

Jama Network Open
Xin, Hao-Yang HY; Sun, Rong-Qi RQ; Zou, Ji-Xue JX; Wang, Peng-Cheng PC; Wang, Jia-Yin JY; Ye, Yu-Hang YH; Liu, Kai-Xuan KX; Hu, Zhi-Qiang ZQ; Zhou, Zheng-Jun ZJ; Fan, Jia J; Zhou, Jian J; Zhou, Shao-Lai SL
Publication Date: 2023-03-01

Variant appearance in text: BRAF: L597V
PubMed Link: 36867406
Variant Present in the following documents:
  • jamanetwopen-e231476-s001.pdf
View BVdb publication page



Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer.

Cancer Discovery
Pradat, Yoann Y; Viot, Julien J; Yurchenko, Andrey A AA; Gunbin, Konstantin K; Cerbone, Luigi L; Deloger, Marc M; Grisay, Guillaume G; Verlingue, Loic L; Scott, Veronique V; Padioleau, Ismael I; Panunzi, Leonardo L; Michiels, Stefan S; Hollebecque, Antoine A; Jules-Clement, Gerome G; Mezquita, Laura L; Laine, Antoine A; Loriot, Yohann Y; Besse, Benjamin B; Friboulet, Luc L; Andre, Fabrice F; Cournede, Paul-Henry PH; Gautheret, Daniel D; Nikolaev, Sergey I SI
Publication Date: 2023-03-02

Variant appearance in text: BRAF: L597V
PubMed Link: 36862804
Variant Present in the following documents:
  • cd-22-0966_supplementary_tables_s1-s11_suppst1.xlsx, sheet 5
View BVdb publication page



Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: BRAF: 1789C>G; Leu597Val
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Tumor-Type Agnostic, Targeted Therapies: BRAF Inhibitors Join the Group.

Acta Medica Academica
Vranic, Semir S; Basu, Gargi D GD; Hall, David W DW; Gatalica, Zoran Z
Publication Date: 2022-12-30

Variant appearance in text: BRAF: L597V
PubMed Link: 36799315
Variant Present in the following documents:
  • AMA-51-217.pdf
View BVdb publication page



Significance of logistic regression scoring model based on natural killer cell-mediated cytotoxic pathway in the diagnosis of colon cancer.

Frontiers In Immunology
Ye, Zhen Z; Zhang, Huanhuan H; Liang, Jianwei J; Yi, Shuying S; Zhan, Xianquan X
Publication Date: 2023

Variant appearance in text: BRAF: L597V; rs121913369
PubMed Link: 36742322
Variant Present in the following documents:
  • Table_8.xlsx, sheet 1
View BVdb publication page



Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications
Boström, Martin M; Larsson, Erik E
Publication Date: 2022-11-17

Variant appearance in text: BRAF: L597V
PubMed Link: 36396655
Variant Present in the following documents:
  • 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Integrated gene analyses of de novo variants from 46,612 trios with autism and developmental disorders.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Wang, Tianyun T; Kim, Chang N CN; Bakken, Trygve E TE; Gillentine, Madelyn A MA; Henning, Barbara B; Mao, Yafei Y; Gilissen, Christian C; , ; Nowakowski, Tomasz J TJ; Eichler, Evan E EE
Publication Date: 2022-11-15

Variant appearance in text: BRAF: 1789C>G; Leu597Val
PubMed Link: 36350923
Variant Present in the following documents:
  • pnas.2203491119.sd01.xlsx, sheet 1
View BVdb publication page



Uterine lavage identifies cancer mutations and increased TP53 somatic mutation burden in individuals with ovarian cancer.

Cancer Research Communications
Ghezelayagh, Talayeh S TS; Kohrn, Brendan F BF; Fredrickson, Jeanne J; Manhardt, Enna E; Radke, Marc R MR; Katz, Ronit R; Gray, Heidi J HJ; Urban, Renata R RR; Pennington, Kathryn P KP; Liao, John B JB; Doll, Kemi M KM; Simons, Elise J EJ; Burzawa, Jennifer K JK; Goff, Barbara A BA; Speiser, Paul P; Swisher, Elizabeth M EM; Norquist, Barbara M BM; Risques, Rosa Ana RA
Publication Date: 2022-10

Variant appearance in text: BRAF: 1789C>G; L597V
PubMed Link: 36311816
Variant Present in the following documents:
  • crc-22-0314-s02.xlsx, sheet 6
View BVdb publication page



Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes.

Nature Genetics
Zhou, Xueya X; Feliciano, Pamela P; Shu, Chang C; Wang, Tianyun T; Astrovskaya, Irina I; Hall, Jacob B JB; Obiajulu, Joseph U JU; Wright, Jessica R JR; Murali, Shwetha C SC; Xu, Simon Xuming SX; Brueggeman, Leo L; Thomas, Taylor R TR; Marchenko, Olena O; Fleisch, Christopher C; Barns, Sarah D SD; Snyder, LeeAnne Green LG; Han, Bing B; Chang, Timothy S TS; Turner, Tychele N TN; Harvey, William T WT; Nishida, Andrew A; O'Roak, Brian J BJ; Geschwind, Daniel H DH; , ; Michaelson, Jacob J JJ; Volfovsky, Natalia N; Eichler, Evan E EE; Shen, Yufeng Y; Chung, Wendy K WK
Publication Date: 2022-09

Variant appearance in text: BRAF: 1789C>G; L597V
PubMed Link: 35982159
Variant Present in the following documents:
  • 41588_2022_1148_MOESM7_ESM.xlsx, sheet 1
View BVdb publication page



Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology
Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M
Publication Date: 2022

Variant appearance in text: BRAF: 1789C>G; L597V
PubMed Link: 35936718
Variant Present in the following documents:
  • Table_4.xlsx, sheet 2
View BVdb publication page



Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.

Nature Genetics
Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS
Publication Date: 2022-08

Variant appearance in text: BRAF: L597V
PubMed Link: 35835912
Variant Present in the following documents:
  • 41588_2022_1121_MOESM3_ESM.xlsx, sheet 3
View BVdb publication page



Clinical Targeted Panel Sequencing Analysis in Clinical Evaluation of Children with Autism Spectrum Disorder in China.

Genes
Hu, Chunchun C; He, Linlin L; Li, Huiping H; Ding, Yanhua Y; Zhang, Kaifeng K; Li, Dongyun D; Zhu, Guoqing G; Wu, Bingbing B; Xu, Xiu X; Xu, Qiong Q
Publication Date: 2022-06-02

Variant appearance in text: BRAF: 1789C>G; L597V
PubMed Link: 35741772
Variant Present in the following documents:
  • genes-13-01010.pdf
View BVdb publication page



Custom multi‑tumor next‑generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three‑year clinical use.

International Journal Of Molecular Medicine
Chevrier, Sandy S; Brasselet, Astrid A; Carnet, Marion M; Chevriaux, Angélique A; Gibeaud, Anne A; Jourdain, Marine M; Mananet, Hugo H; Truntzer, Caroline C; Beltjens, Françoise F; Charon-Barra, Céline C; Arnould, Laurent L; Albuisson, Juliette J; Comte, Anthony A; Derangère, Valentin V; Goussot, Vincent V; Boidot, Romain R
Publication Date: 2022-05

Variant appearance in text: BRAF: 1789C>G; Leu597Val
PubMed Link: 35244186
Variant Present in the following documents:
  • Supplementary_Data2.xlsx, sheet 1
  • Supplementary_Data3.xlsx, sheet 1
View BVdb publication page



The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer
Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J
Publication Date: 2022-02

Variant appearance in text: BRAF: Leu597Val
PubMed Link: 35221333
Variant Present in the following documents:
  • 43018_2022_332_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



The RASopathies: from pathogenetics to therapeutics.

Disease Models & Mechanisms
Hebron, Katie E KE; Hernandez, Edjay Ralph ER; Yohe, Marielle E ME
Publication Date: 2022-02-01

Variant appearance in text: BRAF: L597V
PubMed Link: 35178568
Variant Present in the following documents:
  • Main text
View BVdb publication page



Immune checkpoint inhibitors and driver oncogenes in non-small cell lung cancer.

Translational Cancer Research
Miura, Yosuke Y; Kasahara, Norimitsu N; Sunaga, Noriaki N
Publication Date: 2019-12

Variant appearance in text: BRAF: L597V
PubMed Link: 35117146
Variant Present in the following documents:
  • Main text
  • tcr-08-S6-S628.pdf
View BVdb publication page



Molecular characterization of Kita-Kyushu lung cancer antigen (KK-LC-1) expressing carcinomas.

Oncotarget
Hsu, Robert R; Baca, Yasmine Y; Xiu, Joanne J; Wang, Rongfu R; Bodor, J Nicholas JN; Kim, Chul C; Khan, Hina H; Mamdani, Hirva H; Nagasaka, Misako M; Puri, Sonam S; Liu, Stephen V SV; Korn, W Michael WM; Nieva, Jorge J JJ
Publication Date: 2021-12-07

Variant appearance in text: BRAF: L597V
PubMed Link: 34917263
Variant Present in the following documents:
  • oncotarget-12-2449-s001.pdf
View BVdb publication page



Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer.

Nature Cancer
Westcott, Peter M K PMK; Sacks, Nathan J NJ; Schenkel, Jason M JM; Ely, Zackery A ZA; Smith, Olivia O; Hauck, Haley H; Jaeger, Alex M AM; Zhang, Daniel D; Backlund, Coralie M CM; Beytagh, Mary C MC; Patten, J J JJ; Elbashir, Ryan R; Eng, George G; Irvine, Darrell J DJ; Yilmaz, Omer H OH; Jacks, Tyler T
Publication Date: 2021-10

Variant appearance in text: BRAF: 1789C>G; Leu597Val
PubMed Link: 34738089
Variant Present in the following documents:
  • NIHMS1725490-supplement-Source_Data_Figure_1.xlsx, sheet 1
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: BRAF: L597V
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Improvement of Neoantigen Identification Through Convolution Neural Network.

Frontiers In Immunology
Hao, Qing Q; Wei, Ping P; Shu, Yang Y; Zhang, Yi-Guan YG; Xu, Heng H; Zhao, Jun-Ning JN
Publication Date: 2021

Variant appearance in text: BRAF: L597V
PubMed Link: 34113354
Variant Present in the following documents:
  • Table_1.xlsx, sheet 6
View BVdb publication page



Comparison of two targeted ultra-deep sequencing technologies for analysis of plasma circulating tumour DNA in endocrine-therapy-resistant breast cancer patients.

Breast Cancer Research And Treatment
Nteliopoulos, Georgios G; Page, Karen K; Hills, Allison A; Howarth, Karen K; Emmett, Warren W; Green, Emma E; Martinson, Luke J LJ; Fernadez-Garcia, Daniel D; Hastings, Robert R; Guttery, David S DS; Kenny, Laura L; Stebbing, Justin J; Cleator, Susan S; Rehman, Farah F; Gleason, Kelly L T KLT; Sanela, Andrijac A; Ion, Charlotte C; Rushton, Amelia J AJ; Rosenfeld, Nitzan N; Coombes, R Charles RC; Shaw, Jacqueline A JA
Publication Date: 2021-07

Variant appearance in text: BRAF: L597V
PubMed Link: 34097174
Variant Present in the following documents:
  • 10549_2021_6220_MOESM2_ESM.xlsx, sheet 2
  • 10549_2021_6220_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Evolution of kinase polypharmacology across HSP90 drug discovery.

Cell Chemical Biology
Antolin, Albert A AA; Clarke, Paul A PA; Collins, Ian I; Workman, Paul P; Al-Lazikani, Bissan B
Publication Date: 2021-10-21

Variant appearance in text: BRAF: L597V
PubMed Link: 34077750
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
View BVdb publication page



Defining the Criteria for Reflex Testing for BRAF Mutations in Cutaneous Melanoma Patients.

Cancers
Zhou, Sarah S; Sikorski, Daniel D; Xu, Honghao H; Zubarev, Andrei A; Chergui, May M; Lagacé, François F; Miller, Wilson H WH; Redpath, Margaret M; Ghazal, Stephanie S; Butler, Marcus O MO; Petrella, Teresa M TM; Claveau, Joël J; Nessim, Carolyn C; Salopek, Thomas G TG; Gniadecki, Robert R; Litvinov, Ivan V IV
Publication Date: 2021-05-10

Variant appearance in text: BRAF: L597V
PubMed Link: 34068774
Variant Present in the following documents:
  • Main text
View BVdb publication page



Spatially interacting phosphorylation sites and mutations in cancer.

Nature Communications
Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L
Publication Date: 2021-04-19

Variant appearance in text: BRAF: L597V
PubMed Link: 33875650
Variant Present in the following documents:
  • 41467_2021_22481_MOESM4_ESM.xlsx, sheet 1
  • 41467_2021_22481_MOESM4_ESM.xlsx, sheet 5
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: BRAF: 1789C>G; L597V
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



Mutant-selective degradation by BRAF-targeting PROTACs.

Nature Communications
Alabi, Shanique S; Jaime-Figueroa, Saul S; Yao, Zhan Z; Gao, Yijun Y; Hines, John J; Samarasinghe, Kusal T G KTG; Vogt, Lea L; Rosen, Neal N; Crews, Craig M CM
Publication Date: 2021-02-10

Variant appearance in text: BRAF: L597V
PubMed Link: 33568647
Variant Present in the following documents:
  • Main text
  • 41467_2021_Article_21159.pdf
View BVdb publication page



Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases.

Jama Network Open
Zhao, Yiqing Y; Yu, Hanzhong H; Ida, Cris M CM; Halling, Kevin C KC; Kipp, Benjamin R BR; Geiersbach, Katherine K; Rumilla, Kandelaria M KM; Gupta, Sounak S; Lin, Ming-Tseh MT; Zheng, Gang G
Publication Date: 2021-01-04

Variant appearance in text: BRAF: L597V
PubMed Link: 33507258
Variant Present in the following documents:
  • jamanetwopen-e2035479-s001.pdf
View BVdb publication page



Comprehensive Characterization of Stage IIIA Non-Small Cell Lung Carcinoma.

Cancer Management And Research
Singh, Neetu N; Mishra, Archana A; Sahu, Dinesh Kumar DK; Jain, Mayank M; Shyam, Hari H; Tripathi, Ratnesh Kumar RK; Shankar, Pratap P; Kumar, Anil A; Alam, Nawazish N; Jaiswal, Riddhi R; Kumar, Shailendra S
Publication Date: 2020

Variant appearance in text: BRAF: 1789C>G; L597V
PubMed Link: 33244273
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular and Immune Biomarkers for Cutaneous Melanoma: Current Status and Future Prospects.

Cancers
Pilla, Lorenzo L; Alberti, Andrea A; Di Mauro, Pierluigi P; Gemelli, Maria M; Cogliati, Viola V; Cazzaniga, Marina Elena ME; Bidoli, Paolo P; Maccalli, Cristina C
Publication Date: 2020-11-20

Variant appearance in text: BRAF: L597V
PubMed Link: 33233603
Variant Present in the following documents:
  • Main text
View BVdb publication page



Integrated molecular drivers coordinate biological and clinical states in melanoma.

Nature Genetics
Conway, Jake R JR; Dietlein, Felix F; Taylor-Weiner, Amaro A; AlDubayan, Saud S; Vokes, Natalie N; Keenan, Tanya T; Reardon, Brendan B; He, Meng Xiao MX; Margolis, Claire A CA; Weirather, Jason L JL; Haq, Rizwan R; Schilling, Bastian B; Stephen Hodi, F F; Schadendorf, Dirk D; Liu, David D; Van Allen, Eliezer M EM
Publication Date: 2020-12

Variant appearance in text: rs121913369
PubMed Link: 33230298
Variant Present in the following documents:
  • NIHMS1637640-supplement-SuppData1.xlsx, sheet 1
View BVdb publication page



Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Mayrhofer, Johanna E JE; Enzler, Florian F; Feichtner, Andreas A; Röck, Ruth R; Fleischmann, Jakob J; Raffeiner, Andrea A; Tschaikner, Philipp P; Ogris, Egon E; Huber, Roland G RG; Hartl, Markus M; Schneider, Rainer R; Troppmair, Jakob J; Torres-Quesada, Omar O; Stefan, Eduard E
Publication Date: 2020-12-08

Variant appearance in text: BRAF: L597V
PubMed Link: 33229534
Variant Present in the following documents:
  • Main text
View BVdb publication page



Emerging BRAF Mutations in Cancer Progression and Their Possible Effects on Transcriptional Networks.

Genes
Śmiech, Magdalena M; Leszczyński, Paweł P; Kono, Hidetoshi H; Wardell, Christopher C; Taniguchi, Hiroaki H
Publication Date: 2020-11-12

Variant appearance in text: BRAF: L597V
PubMed Link: 33198372
Variant Present in the following documents:
  • Main text
  • genes-11-01342.pdf
View BVdb publication page



Quantitative Structure-Mutation-Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction.

Bmc Bioinformatics
Huang, Liang-Chin LC; Yeung, Wayland W; Wang, Ye Y; Cheng, Huimin H; Venkat, Aarya A; Li, Sheng S; Ma, Ping P; Rasheed, Khaled K; Kannan, Natarajan N
Publication Date: 2020-11-12

Variant appearance in text: BRAF: L597V
PubMed Link: 33183223
Variant Present in the following documents:
  • Main text
View BVdb publication page



Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity.

Genome Biology
Lee, Won-Chul WC; Reuben, Alexandre A; Hu, Xin X; McGranahan, Nicholas N; Chen, Runzhe R; Jalali, Ali A; Negrao, Marcelo V MV; Hubert, Shawna M SM; Tang, Chad C; Wu, Chia-Chin CC; Lucas, Anthony San AS; Roh, Whijae W; Suda, Kenichi K; Kim, Jihye J; Tan, Aik-Choon AC; Peng, David H DH; Lu, Wei W; Tang, Ximing X; Chow, Chi-Wan CW; Fujimoto, Junya J; Behrens, Carmen C; Kalhor, Neda N; Fukumura, Kazutaka K; Coyle, Marcus M; Thornton, Rebecca R; Gumbs, Curtis C; Li, Jun J; Wu, Chang-Jiun CJ; Little, Latasha L; Roarty, Emily E; Song, Xingzhi X; Lee, J Jack JJ; Sulman, Erik P EP; Rao, Ganesh G; Swisher, Stephen S; Diao, Lixia L; Wang, Jing J; Heymach, John V JV; Huse, Jason T JT; Scheet, Paul P; Wistuba, Ignacio I II; Gibbons, Don L DL; Futreal, P Andrew PA; Zhang, Jianhua J; Gomez, Daniel D; Zhang, Jianjun J
Publication Date: 2020-11-04

Variant appearance in text: BRAF: L597V
PubMed Link: 33148332
Variant Present in the following documents:
  • 13059_2020_2175_MOESM1_ESM.xlsx, sheet 5
View BVdb publication page



Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports
Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O
Publication Date: 2020-10-13

Variant appearance in text: rs121913369
PubMed Link: 33051506
Variant Present in the following documents:
  • 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



KANK1-NTRK3 fusions define a subset of BRAF mutation negative renal metanephric adenomas.

Bmc Medical Genetics
Catic, Aida A; Kurtovic-Kozaric, Amina A; Sophian, Ardis A; Mazur, Lech L; Skenderi, Faruk F; Hes, Ondrej O; Rohan, Stephen S; Rakheja, Dinesh D; Kogan, Jillene J; Pins, Michael R MR
Publication Date: 2020-10-12

Variant appearance in text: BRAF: L597V
PubMed Link: 33046021
Variant Present in the following documents:
  • Main text
  • 12881_2020_Article_1143.pdf
View BVdb publication page



Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports
Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA
Publication Date: 2020-09-21

Variant appearance in text: BRAF: L597V
PubMed Link: 32958805
Variant Present in the following documents:
  • 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2
View BVdb publication page



BRAF in Lung Cancers: Analysis of Patient Cases Reveals Recurrent BRAF Mutations, Fusions, Kinase Duplications, and Concurrent Alterations.

Jco Precision Oncology
Sheikine, Yuri Y; Pavlick, Dean D; Klempner, Samuel J SJ; Trabucco, Sally E SE; Chung, Jon H JH; Rosenzweig, Mark M; Wang, Kai K; Velcheti, Vamsidhar V; Frampton, Garrett M GM; Peled, Nir N; Murray, Molly M; Chae, Young Kwang YK; Albacker, Lee A LA; Gay, Laurie L; Husain, Hatim H; Suh, James H JH; Millis, Sherri Z SZ; Reddy, Venkataprasanth P VP; Elvin, Julia A JA; Hartmaier, Ryan J RJ; Dowlati, Afshin A; Stephens, Phil P; Ross, Jeffrey S JS; Bivona, Trever G TG; Miller, Vincent A VA; Ganesan, Shridar S; Schrock, Alexa B AB; Ou, Sai-Hong Ignatius SI; Ali, Siraj M SM
Publication Date: 2018

Variant appearance in text: BRAF: L597V
PubMed Link: 32913992
Variant Present in the following documents:
  • Main text
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Inhibitors of BRAF dimers using an allosteric site.

Nature Communications
Cotto-Rios, Xiomaris M XM; Agianian, Bogos B; Gitego, Nadege N; Zacharioudakis, Emmanouil E; Giricz, Orsi O; Wu, Yang Y; Zou, Yiyu Y; Verma, Amit A; Poulikakos, Poulikos I PI; Gavathiotis, Evripidis E
Publication Date: 2020-09-01

Variant appearance in text: BRAF: L597V
PubMed Link: 32873792
Variant Present in the following documents:
  • Main text
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Construction of a reference material panel for detecting KRAS/NRAS/EGFR/BRAF/MET mutations in plasma ctDNA.

Journal Of Clinical Pathology
Xu, Jun J; Qu, Shoufang S; Sun, Nan N; Zhang, Wenxin W; Zhang, Juanli J; Song, Qingtao Q; Lin, Mufei M; Gao, Wei W; Zheng, Qiaosong Q; Han, Mipeng M; Na, Chenglong C; Xu, Ren R; Chang, Xiaoyan X; Yang, Xuexi X; Huang, Jie J
Publication Date: 2021-05

Variant appearance in text: BRAF: 1789C>G; L597V
PubMed Link: 32817175
Variant Present in the following documents:
  • Main text
  • jclinpath-2020-206745supp001.pdf
  • jclinpath-2020-206745.pdf
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Functional characterization of a PROTAC directed against BRAF mutant V600E.

Nature Chemical Biology
Posternak, Ganna G; Tang, Xiaojing X; Maisonneuve, Pierre P; Jin, Ting T; Lavoie, Hugo H; Daou, Salima S; Orlicky, Stephen S; Goullet de Rugy, Theo T; Caldwell, Lauren L; Chan, Kin K; Aman, Ahmed A; Prakesch, Michael M; Poda, Gennady G; Mader, Pavel P; Wong, Cassandra C; Maier, Stefan S; Kitaygorodsky, Julia J; Larsen, Brett B; Colwill, Karen K; Yin, Zhe Z; Ceccarelli, Derek F DF; Batey, Robert A RA; Taipale, Mikko M; Kurinov, Igor I; Uehling, David D; Wrana, Jeff J; Durocher, Daniel D; Gingras, Anne-Claude AC; Al-Awar, Rima R; Therrien, Marc M; Sicheri, Frank F
Publication Date: 2020-11

Variant appearance in text: BRAF: L597V
PubMed Link: 32778845
Variant Present in the following documents:
  • Main text
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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine
Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y
Publication Date: 2020-08-01

Variant appearance in text: BRAF: 1789C>G; L597V
PubMed Link: 32738923
Variant Present in the following documents:
  • 12967_2020_2449_MOESM2_ESM.xlsx, sheet 1
  • 12967_2020_2449_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Molecular Basis for Ser/Thr Specificity in PKA Signaling.

Cells
Knape, Matthias J MJ; Wallbott, Maximilian M; Burghardt, Nicole C G NCG; Bertinetti, Daniela D; Hornung, Jan J; Schmidt, Sven H SH; Lorenz, Robin R; Herberg, Friedrich W FW
Publication Date: 2020-06-25

Variant appearance in text: BRAF: L597V
PubMed Link: 32630525
Variant Present in the following documents:
  • Main text
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mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.

Cell Reports
Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM
Publication Date: 2020-06-23

Variant appearance in text: BRAF: L597V
PubMed Link: 32579932
Variant Present in the following documents:
  • mmc5.xlsx, sheet 3
View BVdb publication page



FAM83G Is a Novel Inducer of Apoptosis.

Molecules (Basel, Switzerland)
Okada, Junichi J; Sunaga, Noriaki N; Yamada, Eijiro E; Saito, Tsugumichi T; Ozawa, Atsushi A; Nakajima, Yasuyo Y; Okada, Kazuya K; Pessin, Jeffrey E JE; Okada, Shuichi S; Yamada, Masanobu M
Publication Date: 2020-06-18

Variant appearance in text: BRAF: L597V
PubMed Link: 32570757
Variant Present in the following documents:
  • Main text
  • molecules-25-02810.pdf
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Molecular Landscape of BRAF-Mutant NSCLC Reveals an Association Between Clonality and Driver Mutations and Identifies Targetable Non-V600 Driver Mutations.

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer
Negrao, Marcelo V MV; Raymond, Victoria M VM; Lanman, Richard B RB; Robichaux, Jacqulyne P JP; He, Junqin J; Nilsson, Monique B MB; Ng, Patrick K S PKS; Amador, Bianca E BE; Roarty, Emily B EB; Nagy, Rebecca J RJ; Banks, Kimberly C KC; Zhu, Viola W VW; Ng, Chun C; Chae, Young Kwang YK; Clarke, Jeffrey M JM; Crawford, Jeffrey A JA; Meric-Bernstam, Funda F; Ignatius Ou, Sai-Hong SH; Gandara, David R DR; Heymach, John V JV; Bivona, Trever G TG; McCoach, Caroline E CE
Publication Date: 2020-10

Variant appearance in text: BRAF: L597V
PubMed Link: 32540409
Variant Present in the following documents:
  • Main text
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Tumor Location Is Associated With the Prevalence of Braf And Pik3ca Mutations in Patients with Wild-Type Ras Colorectal Cancer: A Prospective Multi-Center Cohort Study in Japan.

Translational Oncology
Taniguchi, Hiroya H; Uehara, Keisuke K; Nakayama, Goro G; Nakayama, Hiroshi H; Aiba, Toshisada T; Hattori, Norifumi N; Kataoka, Masato M; Nakano, Yasuyuki Y; Kawase, Yoshihisa Y; Okochi, Osamu O; Matsuoka, Hiroshi H; Utsunomiya, Setsuo S; Sakamoto, Eiji E; Mori, Yoshinori Y; Umeda, Shinichi S; Shikano, Toshio T; Komori, Koji K; Tajika, Masahiro M; Kadowaki, Shigenori S; Muro, Kei K; Yatabe, Yasushi Y
Publication Date: 2020-07

Variant appearance in text: BRAF: L597V
PubMed Link: 32428838
Variant Present in the following documents:
  • Main text
  • main.pdf
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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: BRAF: L597V
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 11
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The paradox of cancer genes in non-malignant conditions: implications for precision medicine.

Genome Medicine
Adashek, Jacob J JJ; Kato, Shumei S; Lippman, Scott M SM; Kurzrock, Razelle R
Publication Date: 2020-02-17

Variant appearance in text: BRAF: L597V
PubMed Link: 32066498
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy.

Cells
Degirmenci, Ufuk U; Wang, Mei M; Hu, Jiancheng J
Publication Date: 2020-01-13

Variant appearance in text: BRAF: L597V
PubMed Link: 31941155
Variant Present in the following documents:
  • cells-09-00198.pdf
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Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology
Dong, Xiaobao X; Huang, Dandan D; Yi, Xianfu X; Zhang, Shijie S; Wang, Zhao Z; Yan, Bin B; Chung Sham, Pak P; Chen, Kexin K; Jun Li, Mulin M
Publication Date: 2020-01-07

Variant appearance in text: BRAF: 1789C>G; L597V
PubMed Link: 31925297
Variant Present in the following documents:
  • 42003_2019_736_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



The impact of RASopathy-associated mutations on CNS development in mice and humans.

Molecular Brain
Kang, Minkyung M; Lee, Yong-Seok YS
Publication Date: 2019-11-21

Variant appearance in text: BRAF: L597V
PubMed Link: 31752929
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers.

Nature Communications
Gopal, Priyanka P; Sarihan, Elif Irem EI; Chie, Eui Kyu EK; Kuzmishin, Gwendolyn G; Doken, Semihcan S; Pennell, Nathan A NA; Raymond, Daniel P DP; Murthy, Sudish C SC; Ahmad, Usman U; Raja, Siva S; Almeida, Francisco F; Sethi, Sonali S; Gildea, Thomas R TR; Peacock, Craig D CD; Adams, Drew J DJ; Abazeed, Mohamed E ME
Publication Date: 2019-11-13

Variant appearance in text: BRAF: L597V
PubMed Link: 31723142
Variant Present in the following documents:
  • 41467_2019_Article_13161.pdf
  • 41467_2019_13161_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Targeting Oncogenic BRAF: Past, Present, and Future.

Cancers
Zaman, Aubhishek A; Wu, Wei W; Bivona, Trever G TG
Publication Date: 2019-08-16

Variant appearance in text: BRAF: L597V
PubMed Link: 31426419
Variant Present in the following documents:
  • Main text
  • cancers-11-01197.pdf
View BVdb publication page



Atypical BRAF and NRAS Mutations in Mucosal Melanoma.

Cancers
Dumaz, Nicolas N; Jouenne, Fanélie F; Delyon, Julie J; Mourah, Samia S; Bensussan, Armand A; Lebbé, Céleste C
Publication Date: 2019-08-08

Variant appearance in text: BRAF: L597V
PubMed Link: 31398831
Variant Present in the following documents:
  • Main text
  • cancers-11-01133.pdf
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Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm.

Oncogene
Raimondi, Francesco F; Inoue, Asuka A; Kadji, Francois M N FMN; Shuai, Ni N; Gonzalez, Juan-Carlos JC; Singh, Gurdeep G; de la Vega, Alicia Alonso AA; Sotillo, Rocio R; Fischer, Bernd B; Aoki, Junken J; Gutkind, J Silvio JS; Russell, Robert B RB
Publication Date: 2019-09

Variant appearance in text: BRAF: L597V
PubMed Link: 31337866
Variant Present in the following documents:
  • 41388_2019_895_MOESM2_ESM.xlsx, sheet 8
View BVdb publication page