Publications:

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: BRAF: Lys483Met

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

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MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells.

Communications Biology

Estrada, Charlène C; Mirabal-Ortega, Liliana L; Méry, Laurence L; Dingli, Florent F; Besse, Laetitia L; Messaoudi, Cedric C; Loew, Damarys D; Pouponnot, Celio C; Bertolotto, Corine C; Eychène, Alain A; Druillennec, Sabine S

Publication Date: 2022-01-28

Variant appearance in text: BRAF: K483M

PubMed Link: 35091687

Variant Present in the following documents:

• Main text
• 42003_2022_3049_MOESM1_ESM.pdf

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: BRAF: K483M

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine

Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y

Publication Date: 2020-08-01

Variant appearance in text: BRAF: K483M

PubMed Link: 32738923

Variant Present in the following documents:

• 12967_2020_2449_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: BRAF: K483M

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 11
• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

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RAF dimers control vascular permeability and cytoskeletal rearrangements at endothelial cell-cell junctions.

The Febs Journal

Dorard, Coralie C; Cseh, Botond B; Ehrenreiter, Karin K; Wimmer, Reiner R; Varga, Andrea A; Hirschmugl, Tatjana T; Maier, Barbara B; Kramer, Karina K; Fürlinger, Sabine S; Doma, Eszter E; Baccarini, Manuela M

Publication Date: 2019-06

Variant appearance in text: BRAF: K483M

PubMed Link: 30828992

Variant Present in the following documents:

• Main text
• FEBS-286-2277.pdf

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AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.

Developmental Cell

Wang, Xinbo X; Jin, Jiali J; Wan, Fangning F; Zhao, Linlin L; Chu, Hongshang H; Chen, Cong C; Liao, Guanghong G; Liu, Jian J; Yu, Yue Y; Teng, Hongqi H; Fang, Lan L; Jiang, Cong C; Pan, Weijuan W; Xie, Xin X; Li, Jia J; Lu, Xiaolin X; Jiang, Xuejun X; Ge, Xin X; Ye, Dingwei D; Wang, Ping P

Publication Date: 2019-02-11

Variant appearance in text: BRAF: K483M

PubMed Link: 30595535

Variant Present in the following documents:

• Main text

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Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases.

Science Signaling

Hudson, Andrew M AM; Stephenson, Natalie L NL; Li, Cynthia C; Trotter, Eleanor E; Fletcher, Adam J AJ; Katona, Gitta G; Bieniasz-Krzywiec, Patrycja P; Howell, Matthew M; Wirth, Chris C; Furney, Simon S; Miller, Crispin J CJ; Brognard, John J

Publication Date: 2018-04-17

Variant appearance in text: BRAF: K483M

PubMed Link: 29666306

Variant Present in the following documents:

• Main text

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A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma.

Genome Medicine

Dela Cruz, Filemon S FS; Diolaiti, Daniel D; Turk, Andrew T AT; Rainey, Allison R AR; Ambesi-Impiombato, Alberto A; Andrews, Stuart J SJ; Mansukhani, Mahesh M MM; Nagy, Peter L PL; Alvarez, Mariano J MJ; Califano, Andrea A; Forouhar, Farhad F; Modzelewski, Beata B; Mitchell, Chelsey M CM; Yamashiro, Darrell J DJ; Marks, Lianna J LJ; Glade Bender, Julia L JL; Kung, Andrew L AL

Publication Date: 2016-10-31

Variant appearance in text: BRAF: K483M

PubMed Link: 27799065

Variant Present in the following documents:

• Main text
• 13073_2016_366_MOESM1_ESM.pdf
• 13073_2016_Article_366.pdf

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Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors.

Scientific Reports

Chatelle, Claire V CV; Hövermann, Désirée D; Müller, Anne A; Wagner, Hanna J HJ; Weber, Wilfried W; Radziwill, Gerald G

Publication Date: 2016-03-30

Variant appearance in text: BRAF: K483M

PubMed Link: 27025703

Variant Present in the following documents:

• Main text

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Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants.

The Embo Journal

Köhler, Martin M; Röring, Michael M; Schorch, Björn B; Heilmann, Katharina K; Stickel, Natalie N; Fiala, Gina J GJ; Schmitt, Lisa C LC; Braun, Sandra S; Ehrenfeld, Sophia S; Uhl, Franziska M FM; Kaltenbacher, Thorsten T; Weinberg, Florian F; Herzog, Sebastian S; Zeiser, Robert R; Schamel, Wolfgang W WW; Jumaa, Hassan H; Brummer, Tilman T

Publication Date: 2016-01-18

Variant appearance in text: BRAF: K483M

PubMed Link: 26657898

Variant Present in the following documents:

• Main text

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Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation.

Angewandte Chemie (International Ed. In English)

Jambrina, Pablo G PG; Rauch, Nora N; Pilkington, Ruth R; Rybakova, Katja K; Nguyen, Lan K LK; Kholodenko, Boris N BN; Buchete, Nicolae-Viorel NV; Kolch, Walter W; Rosta, Edina E

Publication Date: 2016-01-18

Variant appearance in text: BRAF: K483M

PubMed Link: 26644280

Variant Present in the following documents:

• Main text
• ANIE-55-983-s001.pdf
• ANIE-55-983.pdf

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Clinical detection and categorization of uncommon and concomitant mutations involving BRAF.

Bmc Cancer

Zheng, Gang G; Tseng, Li-Hui LH; Chen, Guoli G; Haley, Lisa L; Illei, Peter P; Gocke, Christopher D CD; Eshleman, James R JR; Lin, Ming-Tseh MT

Publication Date: 2015-10-24

Variant appearance in text: BRAF: K483M

PubMed Link: 26498038

Variant Present in the following documents:

• Main text

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Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation.

Molecular Cell

Shen, Che-Hung CH; Yuan, Ping P; Perez-Lorenzo, Rolando R; Zhang, Yaqing Y; Lee, Sze Xian SX; Ou, Yang Y; Asara, John M JM; Cantley, Lewis C LC; Zheng, Bin B

Publication Date: 2013-10-24

Variant appearance in text: BRAF: K483M

PubMed Link: 24095280

Variant Present in the following documents:

• Main text

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BRAF inactivation drives aneuploidy by deregulating CRAF.

Cancer Research

Kamata, Tamihiro T; Hussain, Jahan J; Giblett, Susan S; Hayward, Robert R; Marais, Richard R; Pritchard, Catrin C

Publication Date: 2010-11-01

Variant appearance in text: BRAF: K483M

PubMed Link: 20978199

Variant Present in the following documents:

• Main text

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Mutations in the c-Kit gene disrupt mitogen-activated protein kinase signaling during tumor development in adenoid cystic carcinoma of the salivary glands.

Neoplasia (New York, N.Y.)

Tetsu, Osamu O; Phuchareon, Janyaporn J; Chou, Annie A; Cox, Darren P DP; Eisele, David W DW; Jordan, Richard C K RC

Publication Date: 2010-09

Variant appearance in text: BRAF: K483M

PubMed Link: 20824047

Variant Present in the following documents:

• Main text

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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.

Cell

Heidorn, Sonja J SJ; Milagre, Carla C; Whittaker, Steven S; Nourry, Arnaud A; Niculescu-Duvas, Ion I; Dhomen, Nathalie N; Hussain, Jahan J; Reis-Filho, Jorge S JS; Springer, Caroline J CJ; Pritchard, Catrin C; Marais, Richard R

Publication Date: 2010-01-22

Variant appearance in text: BRAF: K483M

PubMed Link: 20141835

Variant Present in the following documents:

• Main text
• mmc2.pdf

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Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors.

Human Molecular Genetics

Anastasaki, Corina C; Estep, Anne L AL; Marais, Richard R; Rauen, Katherine A KA; Patton, E Elizabeth EE

Publication Date: 2009-07-15

Variant appearance in text: BRAF: K483M

PubMed Link: 19376813

Variant Present in the following documents:

• Main text

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