KCNH2 c.1261A>G ;(p.T421A)

Variant ID: 7-150649809-T-C

NM_000238.3(KCNH2):c.1261A>G;(p.T421A)

This variant was identified in 3 publications

View GRCh38 version.




Publications:


Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity.

Nature Communications
Shi, Xiaohan X; Li, Yunguang Y; Yuan, Qiuyue Q; Tang, Shijie S; Guo, Shiwei S; Zhang, Yehan Y; He, Juan J; Zhang, Xiaoyu X; Han, Ming M; Liu, Zhuang Z; Zhu, Yiqin Y; Gao, Suizhi S; Wang, Huan H; Xu, Xiongfei X; Zheng, Kailian K; Jing, Wei W; Chen, Luonan L; Wang, Yong Y; Jin, Gang G; Gao, Dong D
Publication Date: 2022-04-21

Variant appearance in text: KCNH2: T421A
PubMed Link: 35449156
Variant Present in the following documents:
  • 41467_2022_29857_MOESM5_ESM.xlsx, sheet 1
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Molecular dynamics simulations suggest possible activation and deactivation pathways in the hERG channel.

Communications Biology
Costa, Flavio F; Guardiani, Carlo C; Giacomello, Alberto A
Publication Date: 2022-02-24

Variant appearance in text: HERG: T421A
PubMed Link: 35210539
Variant Present in the following documents:
  • 42003_2022_Article_3074.pdf
View BVdb publication page



The S1 helix critically regulates the finely tuned gating of Kv11.1 channels.

The Journal Of Biological Chemistry
Phan, Kevin K; Ng, Chai Ann CA; David, Erikka E; Shishmarev, Dmitry D; Kuchel, Philip W PW; Vandenberg, Jamie I JI; Perry, Matthew D MD
Publication Date: 2017-05-05

Variant appearance in text: Kv11.1: T421A
PubMed Link: 28280240
Variant Present in the following documents:
  • Main text
View BVdb publication page