Publications:

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Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics

G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A

Publication Date: 2022

Variant appearance in text: rs377567759

PubMed Link: 36561320

Variant Present in the following documents:

• Table2.xlsx, sheet 4

View BVdb publication page

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Calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for PP3/BP4 criteria.

American Journal Of Human Genetics

Pejaver, Vikas V; Byrne, Alicia B AB; Feng, Bing-Jian BJ; Pagel, Kymberleigh A KA; Mooney, Sean D SD; Karchin, Rachel R; O'Donnell-Luria, Anne A; Harrison, Steven M SM; Tavtigian, Sean V SV; Greenblatt, Marc S MS; Biesecker, Leslie G LG; Radivojac, Predrag P; Brenner, Steven E SE; ,

Publication Date: 2022-12-01

Variant appearance in text: EGFR: R451C; rs377567759

PubMed Link: 36413997

Variant Present in the following documents:

• mmc3.xlsx, sheet 1

View BVdb publication page

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Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021.

Journal Of Hematology & Oncology

Wu, Qing Q; Qian, Wei W; Sun, Xiaoli X; Jiang, Shaojie S

Publication Date: 2022-10-08

Variant appearance in text: EGFR: R451C

PubMed Link: 36209184

Variant Present in the following documents:

• Main text

View BVdb publication page

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Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance.

Nature Communications

Zhuang, Xinlei X; Wang, Zhe Z; Fan, Jiansheng J; Bai, Xuefei X; Xu, Yingchun Y; Chou, James J JJ; Hou, Tingjun T; Chen, Shuqing S; Pan, Liqiang L

Publication Date: 2022-07-30

Variant appearance in text: EGFR: R451C

PubMed Link: 35907884

Variant Present in the following documents:

• Main text
• 41467_2022_32159_MOESM2_ESM.pdf
• 41467_2022_Article_32159.pdf
• 41467_2022_32159_MOESM1_ESM.pdf

View BVdb publication page

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Drug Resistance in Colorectal Cancer: From Mechanism to Clinic.

Cancers

Wang, Qianyu Q; Shen, Xiaofei X; Chen, Gang G; Du, Junfeng J

Publication Date: 2022-06-14

Variant appearance in text: EGFR: R451C

PubMed Link: 35740594

Variant Present in the following documents:

• Main text
• cancers-14-02928.pdf

View BVdb publication page

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Depleting receptor tyrosine kinases EGFR and HER2 overcomes resistance to EGFR inhibitors in colorectal cancer.

Journal Of Experimental & Clinical Cancer Research : Cr

Yang, Lu L; Bhattacharya, Arup A; Li, Yun Y; Sexton, Sandra S; Ling, Xiang X; Li, Fengzhi F; Zhang, Yuesheng Y

Publication Date: 2022-06-02

Variant appearance in text: EGFR: R451C

PubMed Link: 35650607

Variant Present in the following documents:

• Main text
• 13046_2022_Article_2389.pdf

View BVdb publication page

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Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune escape through PHLPP2/AKT/PD-L1 pathway.

International Journal Of Biological Sciences

Liu, Nannan N; Jiang, Xinxiu X; Guo, Leiming L; Zhang, Chuchu C; Jiang, Meimei M; Sun, Zhuoran Z; Zhang, Yizheng Y; Mi, Wunan W; Li, Jiehan J; Fu, Yang Y; Wang, Feng F; Zhang, Lingling L; Zhang, Yingjie Y

Publication Date: 2022

Variant appearance in text: EGFR: R451C

PubMed Link: 35414774

Variant Present in the following documents:

• ijbsv18p2419.pdf
• ijbsv18p2419s1.pdf

View BVdb publication page

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Clinical and genomic features of Chinese lung cancer patients with germline mutations.

Nature Communications

Peng, Wenying W; Li, Bin B; Li, Jin J; Chang, Lianpeng L; Bai, Jing J; Yi, Yuting Y; Chen, Rongrong R; Zhang, Yanyan Y; Chen, Chen C; Pu, Xingxiang X; Jiang, Meilin M; Li, Jia J; Zhong, Rui R; Xu, Fang F; Chen, Bolin B; Xu, Li L; Wang, Ning N; Huan, Jiaojiao J; Dai, Pingping P; Guan, Yanfang Y; Yang, Ling L; Xia, Xuefeng X; Yi, Xin X; Wang, Jiayin J; Yu, Fenglei F; Wu, Lin L

Publication Date: 2022-03-10

Variant appearance in text: EGFR: 1351C>T; R451C

PubMed Link: 35273153

Variant Present in the following documents:

• 41467_2022_28840_MOESM7_ESM.xlsx, sheet 1

View BVdb publication page

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Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research

Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL

Publication Date: 2022-05

Variant appearance in text: EGFR: R451C

PubMed Link: 35229492

Variant Present in the following documents:

• PCMR-35-369-s003.xlsx, sheet 12

View BVdb publication page

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: EGFR: Arg451Cys

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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A rare multiple primary sarcomatoid carcinoma (SCA) of small intestine harboring driver gene mutations: a case report and a literature review.

Translational Cancer Research

Zhu, Zhu Z; Liu, Xinyi X; Li, Wenliang W; Wen, Zhengqi Z; Ji, Xiang X; Zhou, Ruize R; Tuo, Xiaoyu X; Chen, Yaru Y; Gong, Xian X; Liu, Guifeng G; Zhou, Yanqing Y; Chen, Shifu S; Song, Lele L; Huang, Jian J

Publication Date: 2021-02

Variant appearance in text: EGFR: 1351C>T; R451C

PubMed Link: 35116442

Variant Present in the following documents:

• Main text
• tcr-10-02-1150.pdf

View BVdb publication page

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Mutational landscape of circulating tumor DNA identifies distinct molecular features associated with therapeutic response in patients with metastatic colorectal cancer.

Therapeutic Advances In Medical Oncology

Shi, Min M; Yuan, Hong H; Ji, Jun J; Zhang, Shouwei S; Li, Qingyuan Q; Chen, Yawei Y; Gong, Xiaoli X; Zhu, Zhenggang Z; Zhang, Jun J

Publication Date: 2022

Variant appearance in text: rs377567759

PubMed Link: 35096147

Variant Present in the following documents:

• sj-xls-4-tam-10.1177_17588359211070643.xls, sheet 1

View BVdb publication page

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Combined multimodal ctDNA analysis and radiological imaging for tumor surveillance in Non-small cell lung cancer.

Translational Oncology

Metzenmacher, Martin M; Hegedüs, Balazs B; Forster, Jan J; Schramm, Alexander A; Horn, Peter A PA; Klein, Christoph A CA; Bielefeld, Nicola N; Ploenes, Till T; Aigner, Clemens C; Theegarten, Dirk D; Schildhaus, Hans-Ulrich HU; Siveke, Jens T JT; Schuler, Martin M; Lueong, Smiths S SS

Publication Date: 2021-11-17

Variant appearance in text: EGFR: 1351C>T; Arg451Cys; rs377567759

PubMed Link: 34800919

Variant Present in the following documents:

• mmc3.xlsx, sheet 1

View BVdb publication page

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Combined multimodal ctDNA analysis and radiological imaging for tumor surveillance in Non-small cell lung cancer.

Translational Oncology

Metzenmacher, Martin M; Hegedüs, Balazs B; Forster, Jan J; Schramm, Alexander A; Horn, Peter A PA; Klein, Christoph A CA; Bielefeld, Nicola N; Ploenes, Till T; Aigner, Clemens C; Theegarten, Dirk D; Schildhaus, Hans-Ulrich HU; Siveke, Jens T JT; Schuler, Martin M; Lueong, Smiths S SS

Publication Date: 2022-01

Variant appearance in text: EGFR: 1351C>T; Arg451Cys; rs377567759

PubMed Link: 34800919

Variant Present in the following documents:

• mmc3.xlsx, sheet 1

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: EGFR: R451C

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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Increasing astrogenesis in the developing hippocampus induces autistic-like behavior in mice via enhancing inhibitory synaptic transmission.

Glia

Chen, Juan J; Ma, Xiao-Lin XL; Zhao, Hui H; Wang, Xiao-Yu XY; Xu, Min-Xin MX; Wang, Hua H; Yang, Tian-Qi TQ; Peng, Cheng C; Liu, Shuang-Shuang SS; Huang, Man M; Zhou, Yu-Dong YD; Shen, Yi Y

Publication Date: 2022-01

Variant appearance in text: EGFR: R451C

PubMed Link: 34498776

Variant Present in the following documents:

• Main text

View BVdb publication page

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Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment.

Nature Communications

Sun, Hua H; Cao, Song S; Mashl, R Jay RJ; Mo, Chia-Kuei CK; Zaccaria, Simone S; Wendl, Michael C MC; Davies, Sherri R SR; Bailey, Matthew H MH; Primeau, Tina M TM; Hoog, Jeremy J; Mudd, Jacqueline L JL; Dean, Dennis A DA; Patidar, Rajesh R; Chen, Li L; Wyczalkowski, Matthew A MA; Jayasinghe, Reyka G RG; Rodrigues, Fernanda Martins FM; Terekhanova, Nadezhda V NV; Li, Yize Y; Lim, Kian-Huat KH; Wang-Gillam, Andrea A; Van Tine, Brian A BA; Ma, Cynthia X CX; Aft, Rebecca R; Fuh, Katherine C KC; Schwarz, Julie K JK; Zevallos, Jose P JP; Puram, Sidharth V SV; Dipersio, John F JF; , ; Davis-Dusenbery, Brandi B; Ellis, Matthew J MJ; Lewis, Michael T MT; Davies, Michael A MA; Herlyn, Meenhard M; Fang, Bingliang B; Roth, Jack A JA; Welm, Alana L AL; Welm, Bryan E BE; Meric-Bernstam, Funda F; Chen, Feng F; Fields, Ryan C RC; Li, Shunqiang S; Govindan, Ramaswamy R; Doroshow, James H JH; Moscow, Jeffrey A JA; Evrard, Yvonne A YA; Chuang, Jeffrey H JH; Raphael, Benjamin J BJ; Ding, Li L

Publication Date: 2021-08-24

Variant appearance in text: EGFR: R451C

PubMed Link: 34429404

Variant Present in the following documents:

• 41467_2021_25177_MOESM8_ESM.xlsx, sheet 1

View BVdb publication page

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Resistance to Targeted Therapy and RASSF1A Loss in Melanoma: What Are We Missing?

International Journal Of Molecular Sciences

McKenna, Stephanie S; García-Gutiérrez, Lucía L

Publication Date: 2021-05-12

Variant appearance in text: EGFR: R451C

PubMed Link: 34066022

Variant Present in the following documents:

• Main text
• ijms-22-05115.pdf

View BVdb publication page

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Liquid Biopsy for Prognosis and Treatment in Metastatic Colorectal Cancer: Circulating Tumor Cells vs Circulating Tumor DNA.

Targeted Oncology

Patelli, Giorgio G; Vaghi, Caterina C; Tosi, Federica F; Mauri, Gianluca G; Amatu, Alessio A; Massihnia, Daniela D; Ghezzi, Silvia S; Bonazzina, Erica E; Bencardino, Katia K; Cerea, Giulio G; Siena, Salvatore S; Sartore-Bianchi, Andrea A

Publication Date: 2021-05

Variant appearance in text: EGFR: R451C

PubMed Link: 33738696

Variant Present in the following documents:

• Main text
• 11523_2021_Article_795.pdf

View BVdb publication page

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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: EGFR: 1351C>T; R451C

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

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Ultradeep targeted sequencing of circulating tumor DNA in plasma of early and advanced breast cancer.

Cancer Science

Chin, Yoon Ming YM; Takahashi, Yoko Y; Chan, Hiu Ting HT; Otaki, Masumi M; Fujishima, Makoto M; Shibayama, Tomoko T; Miki, Yoshio Y; Ueno, Takayuki T; Nakamura, Yusuke Y; Low, Siew-Kee SK

Publication Date: 2021-01

Variant appearance in text: EGFR: R451C

PubMed Link: 33075187

Variant Present in the following documents:

• CAS-112-454-s002.xlsx, sheet 5
• CAS-112-454-s002.xlsx, sheet 11
• CAS-112-454-s002.xlsx, sheet 6
• CAS-112-454-s002.xlsx, sheet 9

View BVdb publication page

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Frequency of S492R mutations in the epidermal growth factor receptor: analysis of plasma DNA from patients with metastatic colorectal cancer treated with panitumumab or cetuximab monotherapy.

Cancer Biology & Therapy

Price, Timothy T; Ang, Agnes A; Boedigheimer, Michael M; Kim, Tae Won TW; Li, Jin J; Cascinu, Stefano S; Ruff, Paul P; Satya Suresh, Attili A; Thomas, Anne A; Tjulandin, Sergei S; Peeters, Marc M

Publication Date: 2020-10-02

Variant appearance in text: EGFR: R451C

PubMed Link: 33026965

Variant Present in the following documents:

• Main text
• KCBT_21_1798695.pdf

View BVdb publication page

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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine

Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y

Publication Date: 2020-08-01

Variant appearance in text: EGFR: R451C

PubMed Link: 32738923

Variant Present in the following documents:

• 12967_2020_2449_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Evaluation of circulating tumor DNA as a biomarker in pancreatic cancer with liver metastasis.

Plos One

Uesato, Yasunori Y; Sasahira, Naoki N; Ozaka, Masato M; Sasaki, Takashi T; Takatsuki, Mitsuhisa M; Zembutsu, Hitoshi H

Publication Date: 2020

Variant appearance in text: EGFR: R451C

PubMed Link: 32614932

Variant Present in the following documents:

• pone.0235623.s001.xlsx, sheet 1

View BVdb publication page

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Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.

Cancer

Mack, Philip C PC; Banks, Kimberly C KC; Espenschied, Carin R CR; Burich, Rebekah A RA; Zill, Oliver A OA; Lee, Christine E CE; Riess, Jonathan W JW; Mortimer, Stefanie A SA; Talasaz, AmirAli A; Lanman, Richard B RB; Gandara, David R DR

Publication Date: 2020-07-15

Variant appearance in text: EGFR: R451C

PubMed Link: 32365229

Variant Present in the following documents:

• Main text
• CNCR-126-3219.pdf

View BVdb publication page

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: EGFR: R451C

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 11

View BVdb publication page

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Genetic Profiling of Advanced Melanoma: Candidate Mutations for Predicting Sensitivity and Resistance to Targeted Therapy.

Targeted Oncology

Olbryt, Magdalena M; Pigłowski, Wojciech W; Rajczykowski, Marcin M; Pfeifer, Aleksandra A; Student, Sebastian S; Fiszer-Kierzkowska, Anna A

Publication Date: 2020-02

Variant appearance in text: EGFR: Arg451Cys

PubMed Link: 31980996

Variant Present in the following documents:

• Main text
• 11523_2020_Article_695.pdf
• 11523_2020_695_MOESM1_ESM.pdf

View BVdb publication page

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ResMarkerDB: a database of biomarkers of response to antibody therapy in breast and colorectal cancer.

Database : The Journal Of Biological Databases And Curation

Pérez-Granado, Judith J; Piñero, Janet J; Furlong, Laura I LI

Publication Date: 2019-01-01

Variant appearance in text: EGFR: R451C

PubMed Link: 31169290

Variant Present in the following documents:

• Main text
• baz060.pdf

View BVdb publication page

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Resectable lung lesions malignancy assessment and cancer detection by ultra-deep sequencing of targeted gene mutations in plasma cell-free DNA.

Journal Of Medical Genetics

Peng, Muyun M; Xie, Yuancai Y; Li, Xiaohua X; Qian, Youhui Y; Tu, Xiaonian X; Yao, Xumei X; Cheng, Fangsheng F; Xu, Feiyue F; Kong, Deju D; He, Bing B; Liu, Chaoyu C; Cao, Fengjun F; Yang, Haoxian H; Yu, Fenglei F; Xu, Chuanbo C; Tian, Geng G

Publication Date: 2019-10

Variant appearance in text: EGFR: 1351C>T; Arg451Cys

PubMed Link: 30981987

Variant Present in the following documents:

• jmedgenet-2018-105825supp002.xlsx, sheet 4

View BVdb publication page

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Advantage of Next-Generation Sequencing in Dynamic Monitoring of Circulating Tumor DNA over Droplet Digital PCR in Cetuximab Treated Colorectal Cancer Patients.

Translational Oncology

Zhang, Hangyu H; Liu, Rujiao R; Yan, Cong C; Liu, Lulu L; Tong, Zhou Z; Jiang, Weiqin W; Yao, Ming M; Fang, Weijia W; Chen, Zhiyu Z

Publication Date: 2019-03

Variant appearance in text: EGFR: R451C

PubMed Link: 30562681

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine

Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L

Publication Date: 2018-07-27

Variant appearance in text: EGFR: R451C

PubMed Link: 30053901

Variant Present in the following documents:

• 13073_2018_564_MOESM2_ESM.xlsx, sheet 3

View BVdb publication page

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Clinical Utility of Analyzing Circulating Tumor DNA in Patients with Metastatic Colorectal Cancer.

The Oncologist

Nakamura, Yoshiaki Y; Yoshino, Takayuki T

Publication Date: 2018-11

Variant appearance in text: EGFR: R451C

PubMed Link: 29700206

Variant Present in the following documents:

• Main text

View BVdb publication page

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Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

The Journal Of Pathology

Temko, Daniel D; Van Gool, Inge C IC; Rayner, Emily E; Glaire, Mark M; Makino, Seiko S; Brown, Matthew M; Chegwidden, Laura L; Palles, Claire C; Depreeuw, Jeroen J; Beggs, Andrew A; Stathopoulou, Chaido C; Mason, John J; Baker, Ann-Marie AM; Williams, Marc M; Cerundolo, Vincenzo V; Rei, Margarida M; Taylor, Jenny C JC; Schuh, Anna A; Ahmed, Ahmed A; Amant, Frédéric F; Lambrechts, Diether D; Smit, Vincent Thbm VT; Bosse, Tjalling T; Graham, Trevor A TA; Church, David N DN; Tomlinson, Ian I

Publication Date: 2018-07

Variant appearance in text: EGFR: 1351C>T; R451C

PubMed Link: 29604063

Variant Present in the following documents:

• PATH-245-283-s021.xlsx, sheet 1

View BVdb publication page

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T-cell Acute Lymphoblastic Leukemia Cells Display Activation of Different Survival Pathways.

Journal Of Cancer

Moharram, Sausan A SA; Shah, Kinjal K; Kazi, Julhash U JU

Publication Date: 2017

Variant appearance in text: EGFR: R451C

PubMed Link: 29187889

Variant Present in the following documents:

• Main text
• jcav08p4124.pdf

View BVdb publication page

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Present and future of metastatic colorectal cancer treatment: A review of new candidate targets.

World Journal Of Gastroenterology

Martini, Giulia G; Troiani, Teresa T; Cardone, Claudia C; Vitiello, Pietropaolo P; Sforza, Vincenzo V; Ciardiello, Davide D; Napolitano, Stefania S; Della Corte, Carminia Maria CM; Morgillo, Floriana F; Raucci, Antonio A; Cuomo, Antonio A; Selvaggi, Francesco F; Ciardiello, Fortunato F; Martinelli, Erika E

Publication Date: 2017-07-14

Variant appearance in text: EGFR: R451C

PubMed Link: 28765689

Variant Present in the following documents:

• Main text
• WJG-23-4675.pdf

View BVdb publication page

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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: EGFR: R451C; rs377567759

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1

View BVdb publication page

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New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets.

Autophagy

Mokarram, Pooneh P; Albokashy, Mohammed M; Zarghooni, Maryam M; Moosavi, Mohammad Amin MA; Sepehri, Zahra Z; Chen, Qi Min QM; Hudecki, Andrzej A; Sargazi, Aliyeh A; Alizadeh, Javad J; Moghadam, Adel Rezaei AR; Hashemi, Mohammad M; Movassagh, Hesam H; Klonisch, Thomas T; Owji, Ali Akbar AA; Łos, Marek J MJ; Ghavami, Saeid S

Publication Date: 2017-05-04

Variant appearance in text: EGFR: R451C

PubMed Link: 28358273

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research

Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U

Publication Date: 2017-04

Variant appearance in text: EGFR: R451C

PubMed Link: 28179366

Variant Present in the following documents:

• supp_gr.213546.116_Supplemental_Table_S1.xlsx, sheet 1

View BVdb publication page

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Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.

Nature Communications

Van Emburgh, Beth O BO; Arena, Sabrina S; Siravegna, Giulia G; Lazzari, Luca L; Crisafulli, Giovanni G; Corti, Giorgio G; Mussolin, Benedetta B; Baldi, Federica F; Buscarino, Michela M; Bartolini, Alice A; Valtorta, Emanuele E; Vidal, Joana J; Bellosillo, Beatriz B; Germano, Giovanni G; Pietrantonio, Filippo F; Ponzetti, Agostino A; Albanell, Joan J; Siena, Salvatore S; Sartore-Bianchi, Andrea A; Di Nicolantonio, Federica F; Montagut, Clara C; Bardelli, Alberto A

Publication Date: 2016-12-08

Variant appearance in text: EGFR: R451C

PubMed Link: 27929064

Variant Present in the following documents:

• ncomms13665-s1.pdf

View BVdb publication page

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The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance.

Plos One

Sickmier, E Allen EA; Kurzeja, Robert J M RJ; Michelsen, Klaus K; Vazir, Mukta M; Yang, Evelyn E; Tasker, Andrew S AS

Publication Date: 2016

Variant appearance in text: EGFR: R451C

PubMed Link: 27658254

Variant Present in the following documents:

• Main text
• pone.0163366.pdf

View BVdb publication page

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Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer.

World Journal Of Gastroenterology

Sforza, Vincenzo V; Martinelli, Erika E; Ciardiello, Fortunato F; Gambardella, Valentina V; Napolitano, Stefania S; Martini, Giulia G; Della Corte, Carminia C; Cardone, Claudia C; Ferrara, Marianna L ML; Reginelli, Alfonso A; Liguori, Giuseppina G; Belli, Giulio G; Troiani, Teresa T

Publication Date: 2016-07-28

Variant appearance in text: EGFR: R451C

PubMed Link: 27605871

Variant Present in the following documents:

• Main text

View BVdb publication page

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A Landscape of Pharmacogenomic Interactions in Cancer.

Cell

Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ

Publication Date: 2016-07-28

Variant appearance in text: EGFR: 1351C>T; R451C

PubMed Link: 27397505

Variant Present in the following documents:

• mmc3.xlsx, sheet 3

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Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma.

Oncotarget

Braig, Friederike F; Voigtlaender, Minna M; Schieferdecker, Aneta A; Busch, Chia-Jung CJ; Laban, Simon S; Grob, Tobias T; Kriegs, Malte M; Knecht, Rainald R; Bokemeyer, Carsten C; Binder, Mascha M

Publication Date: 2016-07-12

Variant appearance in text: EGFR: R451C

PubMed Link: 27119512

Variant Present in the following documents:

• Main text
• oncotarget-07-42988.pdf

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Colorectal cancer: Overcoming resistance to anti-EGFR therapy - where do we stand?

Nature Reviews. Gastroenterology & Hepatology

Schirripa, Marta M; Lenz, Heinz-Josef HJ

Publication Date: 2016-05

Variant appearance in text: EGFR: Arg451Cys

PubMed Link: 27006256

Variant Present in the following documents:

• Main text

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Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers.

British Journal Of Cancer

Khelwatty, Said A SA; Essapen, Sharadah S; Seddon, Alan M AM; Fan, Zhen Z; Modjtahedi, Helmout H

Publication Date: 2015-09-29

Variant appearance in text: EGFR: R451C

PubMed Link: 26372697

Variant Present in the following documents:

• Main text
• bjc2015319a.pdf

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