Publications:

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Case Report: Blinatumomab therapy for the treatment of B-cell acute lymphoblastic leukemia patients with central nervous system infiltration.

Frontiers In Immunology

Cao, Han-Yu HY; Chen, Hui H; Liu, Song-Bai SB; Gong, Wen-Jie WJ; Qian, Chong-Sheng CS; Zhang, Tong-Tong TT; Wan, Chao-Ling CL; Huang, Si-Man SM; Xu, Nan N; Dai, Hai-Ping HP; Xue, Sheng-Li SL

Publication Date: 2023

Variant appearance in text: NRAS: Gly13Arg

PubMed Link: 37143650

Variant Present in the following documents:

• Main text
• fimmu-14-1181620.pdf

View BVdb publication page

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Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Nature Communications

Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA

Publication Date: 2023-04-03

Variant appearance in text: NRAS: G13R

PubMed Link: 37012232

Variant Present in the following documents:

• 41467_2023_37547_MOESM12_ESM.xlsx, sheet 2

View BVdb publication page

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Deep genomic characterization highlights complexities and prognostic markers of pediatric acute myeloid leukemia.

Communications Biology

Cheng, Chi-Keung CK; Yung, Yuk-Lin YL; Chan, Hoi-Yun HY; Leung, Kam-Tong KT; Chan, Kathy Y Y KYY; Leung, Alex W K AWK; Cheng, Frankie W T FWT; Li, Chi-Kong CK; Wan, Thomas S K TSK; Luo, Xi X; Pitts, Herbert-Augustus HA; Cheung, Joyce S JS; Chan, Natalie P H NPH; Ng, Margaret H L MHL

Publication Date: 2023-03-31

Variant appearance in text: NRAS: 37G>C; G13R; rs121434595

PubMed Link: 37002311

Variant Present in the following documents:

• 42003_2023_4732_MOESM5_ESM.xlsx, sheet 1

View BVdb publication page

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Late-stage metastatic melanoma emerges through a diversity of evolutionary pathways.

Cancer Discovery

Spain, Lavinia L; Coulton, Alexander A; Lobon, Irene I; Rowan, Andrew A; Schnidrig, Desiree D; Shepherd, Scott T C STC; Shum, Benjamin B; Byrne, Fiona F; Goicoechea, Maria M; Piperni, Elisa E; Au, Lewis L; Edmonds, Kim K; Carlyle, Eleanor E; Hunter, Nikki N; Renn, Alexandra A; Messiou, Christina C; Hughes, Peta P; Nobbs, Jaime J; Foijer, Floris F; van den Bos, Hilda H; Wardenaar, Rene R; Spierings, Diana C J DCJ; Spencer, Charlotte C; Schmitt, Andreas M AM; Tippu, Zayd Z; Lingard, Karla K; Grostate, Lauren L; Peat, Kema K; Kelly, Kayleigh K; Sarker, Sarah S; Vaughan, Sarah S; Mangwende, Mary M; Terry, Lauren L; Kelly, Denise D; Biano, Jennifer J; Murra, Aida A; Korteweg, Justine J; Lewis, Charlotte C; OFlaherty, Molly M; Cattin, Anne-Laure AL; Emmerich, Max M; Gerard, Camille L CL; Pallikonda, Husayn Ahmed HA; Lynch, Joanna J; Mason, Robert R; Rogiers, Aljosja A; Xu, Hang H; Huebner, Ariana A; McGranahan, Nicholas N; Al Bakir, Maise M; Murai, Jun J; Naceur-Lombardelli, Cristina C; Borg, Elaine E; Mitchison, Miriam M; Moore, David A DA; Falzon, Mary M; Proctor, Ian I; Stamp, Gordon W H GWH; Nye, Emma L EL; Young, Kate K; Furness, Andrew J S AJS; Pickering, Lisa L; Stewart, Ruby R; Mahadeva, Ula U; Green, Anna A; Larkin, James J; Litchfield, Kevin K; Swanton, Charles C; Jamal-Hanjani, Mariam M; Turajlic, Samra S

Publication Date: 2023-03-28

Variant appearance in text: NRAS: G13R

PubMed Link: 36977461

Variant Present in the following documents:

• Main text
• 1364.pdf

View BVdb publication page

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Circulating Tumor DNA Monitoring Reveals Molecular Progression before Radiologic Progression in a Real-life Cohort of Patients with Advanced Non-small Cell Lung Cancer.

Cancer Research Communications

Frank, Malene S MS; Andersen, Christina S A CSA; Ahlborn, Lise B LB; Pallisgaard, Niels N; Bodtger, Uffe U; Gehl, Julie J

Publication Date: 2022-10

Variant appearance in text: NRAS: 37G>C; G13R

PubMed Link: 36969747

Variant Present in the following documents:

• crc-22-0258-s09.xlsx, sheet 1
• crc-22-0258-s08.xlsx, sheet 1

View BVdb publication page

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KRAS, NRAS, BRAF, HER2 and MSI Status in a Large Consecutive Series of Colorectal Carcinomas.

International Journal Of Molecular Sciences

Martianov, Aleksandr S AS; Mitiushkina, Natalia V NV; Ershova, Anastasia N AN; Martynenko, Darya E DE; Bubnov, Mikhail G MG; Amankwah, Priscilla P; Yanus, Grigory A GA; Aleksakhina, Svetlana N SN; Tiurin, Vladislav I VI; Venina, Aigul R AR; Anuskina, Aleksandra A AA; Gorgul, Yuliy A YA; Shestakova, Anna D AD; Maidin, Mikhail A MA; Belyaev, Alexey M AM; Baboshkina, Liliya S LS; Iyevleva, Aglaya G AG; Imyanitov, Evgeny N EN

Publication Date: 2023-03-02

Variant appearance in text: NRAS: G13R

PubMed Link: 36902296

Variant Present in the following documents:

• Main text

View BVdb publication page

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Minimal residual disease detection by mutation-specific droplet digital PCR for leukemia/lymphoma.

International Journal Of Hematology

Shirai, Ryota R; Osumi, Tomoo T; Keino, Dai D; Nakabayashi, Kazuhiko K; Uchiyama, Toru T; Sekiguchi, Masahiro M; Hiwatari, Mitsuteru M; Yoshida, Masanori M; Yoshida, Kaoru K; Yamada, Yuji Y; Tomizawa, Daisuke D; Takae, Seido S; Kiyokawa, Nobutaka N; Matsumoto, Kimikazu K; Yoshioka, Takako T; Hata, Kenichiro K; Hori, Toshinori T; Suzuki, Nao N; Kato, Motohiro M

Publication Date: 2023-03-03

Variant appearance in text: NRAS: G13R

PubMed Link: 36867356

Variant Present in the following documents:

• 12185_2023_3566_MOESM1_ESM.pdf

View BVdb publication page

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KRAS, NRAS, BRAF signatures, and MMR status in colorectal cancer patients in North China.

Medicine

Lian, Shen-Yi SY; Tan, Lu-Xin LX; Liu, Xin-Zhi XZ; Yang, Lu-Jing LJ; Li, Ning-Ning NN; Feng, Qing Q; Wang, Ping P; Wang, Yue Y; Qiao, Dong-Bo DB; Zhou, Li-Xin LX; Sun, Ting-Ting TT; Wang, Lin L; Wu, Ai-Wen AW; Li, Zhong-Wu ZW

Publication Date: 2023-03-03

Variant appearance in text: NRAS: G13R

PubMed Link: 36862900

Variant Present in the following documents:

• Main text
• medi-102-e33115.pdf

View BVdb publication page

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High-risk multiple myeloma predicted by circulating plasma cells and its genetic characteristics.

Frontiers In Oncology

Xia, Yuan Y; Shen, Na N; Zhang, Run R; Wu, Yujie Y; Shi, Qinglin Q; Li, Jianyong J; Chen, Lijuan L; Xu, Min M; Jin, Yuanyuan Y

Publication Date: 2023

Variant appearance in text: rs121434595

PubMed Link: 36845679

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: NRAS: 37G>C; Gly13Arg

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

View BVdb publication page

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Analysis of clinical and genomic profiles of therapy-related myeloid neoplasm in Korea.

Human Genomics

Yun, Jiwon J; Song, Hyojin H; Kim, Sung-Min SM; Kim, Soonok S; Kwon, Seok Ryun SR; Lee, Young Eun YE; Jeong, Dajeong D; Park, Jae Hyeon JH; Kwon, Sunghoon S; Yun, Hongseok H; Lee, Dong Soon DS

Publication Date: 2023-02-23

Variant appearance in text: NRAS: 37G>C; Gly13Arg

PubMed Link: 36814285

Variant Present in the following documents:

• 40246_2023_458_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Circulating tumour DNA analysis predicts relapse and improves risk stratification in primary refractory multiple myeloma.

Blood Cancer Journal

Mithraprabhu, Sridurga S; Reynolds, John J; Turner, Rose R; Quach, Hang H; Horvath, Noemi N; Kerridge, Ian I; Kalff, Anna A; Bergin, Krystal K; Hocking, Jay J; Yuen, Flora F; Khong, Tiffany T; Durie, Brian M BM; Spencer, Andrew A

Publication Date: 2023-02-13

Variant appearance in text: NRAS: 37G>C; G13R

PubMed Link: 36781844

Variant Present in the following documents:

• 41408_2023_796_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Dynamics of age- versus therapy-related clonal hematopoiesis in long-term survivors of pediatric cancer.

Cancer Discovery

Hagiwara, Kohei K; Natarajan, Sivaraman S; Wang, Zhaoming Z; Zubair, Haseeb H; Mulder, Heather L HL; Dong, Li L; Plyler, Emily M EM; Thimmaiah, Padma P; Ma, Xiaotu X; Ness, Kirsten K KK; Li, Zhenghong Z; Mulrooney, Daniel A DA; Wilson, Carmen L CL; Yasui, Yutaka Y; Hudson, Melissa M MM; Easton, John J; Robison, Leslie L LL; Zhang, Jinghui J

Publication Date: 2023-02-08

Variant appearance in text: NRAS: G13R

PubMed Link: 36751942

Variant Present in the following documents:

• cd-22-0956_tables_s2_s7_s8_s9_suppst1.xlsx, sheet 1
• cd-22-0956_tables_s2_s7_s8_s9_suppst1.xlsx, sheet 4

View BVdb publication page

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Combined KRAS G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS G12C -driven cancers by addressing intrinsic and acquired resistance.

Biorxiv : The Preprint Server For Biology

Thatikonda, Venu V; Lu, Hengyu H; Jurado, Sabine S; Kostyrko, Kaja K; Bristow, Christopher A CA; Bosch, Karin K; Feng, Ningping N; Gao, Sisi S; Gerlach, Daniel D; Gmachl, Michael M; Lieb, Simone S; Jeschko, Astrid A; Machado, Annette A AA; Marszalek, Ethan D ED; Mahendra, Mikhila M; Jaeger, Philipp A PA; Sorokin, Alexey A; Strauss, Sandra S; Trapani, Francesca F; Kopetz, Scott S; Vellano, Christopher P CP; Petronczki, Mark M; Kraut, Norbert N; Heffernan, Timothy P TP; Marszalek, Joseph R JR; Pearson, Mark M; Waizenegger, Irene I; Hofmann, Marco H MH

Publication Date: 2023-01-23

Variant appearance in text: NRAS: G13R

PubMed Link: 36747713

Variant Present in the following documents:

• media-1.xlsx, sheet 4

View BVdb publication page

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Spectrum and clinical features of gene mutations in Chinese pediatric acute lymphoblastic leukemia.

Bmc Pediatrics

Shen, Diying D; Liu, Lixia L; Xu, Xiaojun X; Song, Hua H; Zhang, Jingying J; Xu, Weiqun W; Zhao, Fenying F; Liang, Juan J; Liao, Chan C; Wang, Yan Y; Xia, Tian T; Wang, Chengcheng C; Lou, Feng F; Cao, Shanbo S; Qin, Jiayue J; Tang, Yongmin Y

Publication Date: 2023-02-04

Variant appearance in text: NRAS: 37G>C; G13R

PubMed Link: 36739388

Variant Present in the following documents:

• 12887_2023_3856_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Clinical impact of exome sequencing in the setting of a general pediatric ward for hospitalized children with suspected genetic disorders.

Frontiers In Genetics

Kagan, Maayan M; Semo-Oz, Rotem R; Ben Moshe, Yishay Y; Atias-Varon, Danit D; Tirosh, Irit I; Stern-Zimmer, Michal M; Eliyahu, Aviva A; Raas-Rothschild, Annick A; Bivas, Maayan M; Shlomovitz, Omer O; Chorin, Odelia O; Rock, Rachel R; Tzadok, Michal M; Ben-Zeev, Bruria B; Heimer, Gali G; Bolkier, Yoav Y; Gruber, Noah N; Dagan, Adi A; Bar Aluma, Bat El BE; Pessach, Itai M IM; Rechavi, Gideon G; Barel, Ortal O; Pode-Shakked, Ben B; Anikster, Yair Y; Vivante, Asaf A

Publication Date: 2022

Variant appearance in text: NRAS: 37G>C; Gly13Arg

PubMed Link: 36699461

Variant Present in the following documents:

• Main text
• fgene-13-1018062.pdf

View BVdb publication page

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Efficacy of Dabrafenib and Trametinib in a Patient with Squamous-Cell Carcinoma, with Mutation p.D594G in BRAF and p.R461* in NF1 Genes-A Case Report with Literature Review.

International Journal Of Molecular Sciences

Grenda, Anna A; Krawczyk, Pawel P; Targowska-Duda, Katarzyna M KM; Kieszko, Robert R; Paśnik, Iwona I; Milanowski, Janusz J

Publication Date: 2023-01-07

Variant appearance in text: NRAS: G13R

PubMed Link: 36674722

Variant Present in the following documents:

• Main text
• ijms-24-01195.pdf

View BVdb publication page

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Targeting KRAS G12C mutations in colorectal cancer.

Gastroenterology Report

Zhao, Ming-He MH; Wu, Ai-Wen AW

Publication Date: 2023

Variant appearance in text: NRAS: G13R

PubMed Link: 36632627

Variant Present in the following documents:

• Main text
• goac083.pdf

View BVdb publication page

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Molecular underpinnings of exceptional response in primary malignant melanoma of the esophagus to anti-PD-1 monotherapy.

Journal For Immunotherapy Of Cancer

Dai, Jie J; Bai, Xue X; Gao, Xuan X; Tang, Lirui L; Chen, Yu Y; Sun, Linzi L; Wei, Xiaoting X; Li, Caili C; Qi, Zhonghui Z; Kong, Yan Y; Cui, Chuanliang C; Chi, Zhihong Z; Sheng, Xinan X; Xu, Zelong Z; Lian, Bin B; Li, Siming S; Yan, Xieqiao X; Tang, Bixia B; Zhou, Li L; Wang, Xuan X; Xia, Xuefeng X; Guo, Jun J; Mao, Lili L; Si, Lu L

Publication Date: 2023-01

Variant appearance in text: NRAS: Gly13Arg

PubMed Link: 36593066

Variant Present in the following documents:

• jitc-2022-005937supp007.xls, sheet 1

View BVdb publication page

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Case report: Treatment of metastatic dedifferentiated chondrosarcoma with pembrolizumab yields sustained complete response.

Frontiers In Oncology

Singh, Amisha A; Thorpe, Steven W SW; Darrow, Morgan M; Carr-Ascher, Janai R JR

Publication Date: 2022

Variant appearance in text: NRAS: G13R

PubMed Link: 36465334

Variant Present in the following documents:

• Main text
• fonc-12-991724.pdf

View BVdb publication page

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Transcriptome-based molecular subtypes and differentiation hierarchies improve the classification framework of acute myeloid leukemia.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Cheng, Wen-Yan WY; Li, Jian-Feng JF; Zhu, Yong-Mei YM; Lin, Xiang-Jie XJ; Wen, Li-Jun LJ; Zhang, Fan F; Zhang, Yu-Liang YL; Zhao, Ming M; Fang, Hai H; Wang, Sheng-Yue SY; Lin, Xiao-Jing XJ; Qiao, Niu N; Yin, Wei W; Zhang, Jia-Nan JN; Dai, Yu-Ting YT; Jiang, Lu L; Sun, Xiao-Jian XJ; Xu, Yi Y; Zhang, Tong-Tong TT; Chen, Su-Ning SN; Zhu, Hong-Hu HH; Chen, Zhu Z; Jin, Jie J; Wu, De-Pei DP; Shen, Yang Y; Chen, Sai-Juan SJ

Publication Date: 2022-12-06

Variant appearance in text: NRAS: 37G>C; G13R

PubMed Link: 36442087

Variant Present in the following documents:

• pnas.2211429119.sd02.xlsx, sheet 1

View BVdb publication page

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A sex-informed approach to improve the personalised decision making process in myelodysplastic syndromes: a multicentre, observational cohort study.

The Lancet. Haematology

,

Publication Date: 2022-11-24

Variant appearance in text: NRAS: 37G>C; G13R

PubMed Link: 36436542

Variant Present in the following documents:

• mmc2.xlsx, sheet 1

View BVdb publication page

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Decoding molecular programs in melanoma brain metastases.

Nature Communications

Radke, Josefine J; Schumann, Elisa E; Onken, Julia J; Koll, Randi R; Acker, Güliz G; Bodnar, Bohdan B; Senger, Carolin C; Tierling, Sascha S; Möbs, Markus M; Vajkoczy, Peter P; Vidal, Anna A; Högler, Sandra S; Kodajova, Petra P; Westphal, Dana D; Meier, Friedegund F; Heppner, Frank F; Kreuzer-Redmer, Susanne S; Grebien, Florian F; Jürchott, Karsten K; Redmer, Torben T

Publication Date: 2022-11-26

Variant appearance in text: NRAS: G13R

PubMed Link: 36435874

Variant Present in the following documents:

• 41467_2022_34899_MOESM18_ESM.xlsx, sheet 34
• 41467_2022_34899_MOESM1_ESM.pdf

View BVdb publication page

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HSPB8 counteracts tumor activity of BRAF- and NRAS-mutant melanoma cells by modulation of RAS-prenylation and autophagy.

Cell Death & Disease

Cristofani, Riccardo R; Piccolella, Margherita M; Montagnani Marelli, Marina M; Tedesco, Barbara B; Poletti, Angelo A; Moretti, Roberta Manuela RM

Publication Date: 2022-11-18

Variant appearance in text: NRAS: G13R

PubMed Link: 36400750

Variant Present in the following documents:

• Main text

View BVdb publication page

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Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications

Boström, Martin M; Larsson, Erik E

Publication Date: 2022-11-17

Variant appearance in text: NRAS: G13R

PubMed Link: 36396655

Variant Present in the following documents:

• 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1

View BVdb publication page

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Genomic landscape of the immunogenicity regulation in skin melanomas with diverse tumor mutation burden.

Frontiers In Immunology

Georgoulias, George G; Zaravinos, Apostolos A

Publication Date: 2022

Variant appearance in text: NRAS: G13R

PubMed Link: 36389735

Variant Present in the following documents:

• Table_7.xlsx, sheet 9

View BVdb publication page

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Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing.

Life Science Alliance

Chow, Signy S; Kis, Olena O; Mulder, David T DT; Danesh, Arnavaz A; Bruce, Jeff J; Wang, Ting Ting TT; Reece, Donna D; Bhalis, Nizar N; Neri, Paola P; Sabatini, Peter Jb PJ; Keats, Jonathan J; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2023-01

Variant appearance in text: NRAS: G13R

PubMed Link: 36328595

Variant Present in the following documents:

• Main text
• LSA-2022-01543.pdf

View BVdb publication page

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Pure (acute) erythroid leukemia: morphology, immunophenotype, cytogenetics, mutations, treatment details, and survival data among 41 Mayo Clinic cases.

Blood Cancer Journal

Reichard, Kaaren K KK; Tefferi, Ayalew A; Abdelmagid, Maymona M; Orazi, Attilio A; Alexandres, Christina C; Haack, Joanna J; Greipp, Patricia T PT

Publication Date: 2022-11-02

Variant appearance in text: NRAS: Gly13Arg

PubMed Link: 36323674

Variant Present in the following documents:

• Main text
• 41408_2022_Article_746.pdf

View BVdb publication page

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Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma.

Blood

Ansari-Pour, Naser N; Samur, Mehmet K MK; Flynt, Erin E; Gooding, Sarah S; Towfic, Fadi F; Stong, Nicholas N; Ortiz Estevez, Maria M; Mavrommatis, Konstantinos K; Walker, Brian A BA; Morgan, Gareth J GJ; Munshi, Nikhil C NC; Avet Loiseau, Herve H; Thakurta, Anjan A

Publication Date: 2022-10-12

Variant appearance in text: NRAS: G13R

PubMed Link: 36223594

Variant Present in the following documents:

• BLOOD_BLD-2022-017010-mmc2.xlsx, sheet 1

View BVdb publication page

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The mutational landscape of cancer's vulnerability to ionizing radiation.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Gopal, Priyanka P; Yard, Brian D BD; Petty, Aaron A; Lal, Jessica C JC; Bera, Titas K TK; Hoang, Trung Q TQ; Buhimschi, Alexandru B AB; Abazeed, Mohamed E ME

Publication Date: 2022-10-12

Variant appearance in text: NRAS: G13R

PubMed Link: 36222846

Variant Present in the following documents:

• ccr-22-1914_supplementary_data_2_suppds2.xlsx, sheet 1
• ccr-22-1914_supplementary_data_3_suppds3.xlsx, sheet 1

View BVdb publication page

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Mutually exclusive genetic interactions and gene essentiality shape the genomic landscape of primary melanoma.

The Journal Of Pathology

Birkeälv, Sofia S; Harland, Mark M; Matsuyama, Larissa Satiko Alcantara Sekimoto LSAS; Rashid, Mamun M; Mehta, Ishan I; Laye, Jonathan P JP; Haase, Kerstin K; Mell, Tracey T; Iyer, Vivek V; Robles-Espinoza, Carla Daniela CD; McDermott, Ultan U; van Loo, Peter P; Kuijjer, Marieke L ML; Possik, Patricia A PA; Maria Engler, Silvya Stuchi SS; Bishop, D Timothy DT; Newton-Bishop, Julia J; Adams, David J DJ

Publication Date: 2022-10-11

Variant appearance in text: NRAS: G13R

PubMed Link: 36219477

Variant Present in the following documents:

• PATH-259-56-s006.xlsx, sheet 2
• PATH-259-56-s004.xlsx, sheet 2

View BVdb publication page

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Computational Analysis of Deleterious SNPs in NRAS to Assess Their Potential Correlation With Carcinogenesis.

Frontiers In Genetics

Behairy, Mohammed Y MY; Soltan, Mohamed A MA; Adam, Mohamed S MS; Refaat, Ahmed M AM; Ezz, Ehab M EM; Albogami, Sarah S; Fayad, Eman E; Althobaiti, Fayez F; Gouda, Ahmed M AM; Sileem, Ashraf E AE; Elfaky, Mahmoud A MA; Darwish, Khaled M KM; Alaa Eldeen, Muhammad M

Publication Date: 2022

Variant appearance in text: NRAS: G13R; rs121434595

PubMed Link: 36051694

Variant Present in the following documents:

• Main text
• fgene-13-872845.pdf

View BVdb publication page

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Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.

Nature Communications

Isobe, Tomoya T; Takagi, Masatoshi M; Sato-Otsubo, Aiko A; Nishimura, Akira A; Nagae, Genta G; Yamagishi, Chika C; Tamura, Moe M; Tanaka, Yosuke Y; Asada, Shuhei S; Takeda, Reina R; Tsuchiya, Akiho A; Wang, Xiaonan X; Yoshida, Kenichi K; Nannya, Yasuhito Y; Ueno, Hiroo H; Akazawa, Ryo R; Kato, Itaru I; Mikami, Takashi T; Watanabe, Kentaro K; Sekiguchi, Masahiro M; Seki, Masafumi M; Kimura, Shunsuke S; Hiwatari, Mitsuteru M; Kato, Motohiro M; Fukuda, Shiro S; Tatsuno, Kenji K; Tsutsumi, Shuichi S; Kanai, Akinori A; Inaba, Toshiya T; Shiozawa, Yusuke Y; Shiraishi, Yuichi Y; Chiba, Kenichi K; Tanaka, Hiroko H; Kotecha, Rishi S RS; Cruickshank, Mark N MN; Ishikawa, Fumihiko F; Morio, Tomohiro T; Eguchi, Mariko M; Deguchi, Takao T; Kiyokawa, Nobutaka N; Arakawa, Yuki Y; Koh, Katsuyoshi K; Aoki, Yuki Y; Ishihara, Takashi T; Tomizawa, Daisuke D; Miyamura, Takako T; Ishii, Eiichi E; Mizutani, Shuki S; Wilson, Nicola K NK; Göttgens, Berthold B; Miyano, Satoru S; Kitamura, Toshio T; Goyama, Susumu S; Yokoyama, Akihiko A; Aburatani, Hiroyuki H; Ogawa, Seishi S; Takita, Junko J

Publication Date: 2022-08-30

Variant appearance in text: NRAS: G13R

PubMed Link: 36042201

Variant Present in the following documents:

• 41467_2022_32266_MOESM12_ESM.xlsx, sheet 1

View BVdb publication page

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Successful treatment with MEK-inhibitor in a patient with NRAS-related cutaneous skeletal hypophosphatemia syndrome.

Genes, Chromosomes & Cancer

Carli, Diana D; Cardaropoli, Simona S; Tessaris, Daniele D; Coppo, Paola P; La Selva, Roberta R; Cesario, Claudia C; Lepri, Francesca Romana FR; Pullano, Verdiana V; Palumbo, Martina M; Ramenghi, Ugo U; Brusco, Alfredo A; Medico, Enzo E; De Sanctis, Luisa L; Ferrero, Giovanni Battista GB; Mussa, Alessandro A

Publication Date: 2022-12

Variant appearance in text: NRAS: Gly13Arg

PubMed Link: 35999193

Variant Present in the following documents:

• Main text
• GCC-61-740.pdf

View BVdb publication page

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Conquering oncogenic KRAS and its bypass mechanisms.

Theranostics

Hou, Pingping P; Wang, Y Alan YA

Publication Date: 2022

Variant appearance in text: NRAS: G13R

PubMed Link: 35966590

Variant Present in the following documents:

• Main text
• thnov12p5691.pdf

View BVdb publication page

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Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine.

Blood Cancer Discovery

Wang, Han H; Chan, Kathy Yuen Yee KYY; Cheng, Chi Keung CK; Ng, Margaret H L MHL; Lee, Po Yi PY; Cheng, Frankie Wai Tsoi FWT; Lam, Grace Kee See GKS; Chow, Tin Wai TW; Ha, Shau Yin SY; Chiang, Alan K S AKS; Leung, Wing Hang WH; Leung, Anskar Y H AYH; Wang, Chi Chiu CC; Zhang, Tao T; Zhang, Xiao-Bing XB; So, Chi Chiu CC; Yuen, Yuet Ping YP; Sun, Qiwei Q; Zhang, Chi C; Xu, Yaqun Y; Cheung, John Tak Kit JTK; Ng, Wing Hei WH; Tang, Patrick Ming-Kuen PM; Kang, Wei W; To, Ka-Fai KF; Lee, Wayne Yuk Wai WYW; Wong, Raymond S M RSM; Poon, Ellen Ngar Yun ENY; Zhao, Qi Q; Huang, Junbin J; Chen, Chun C; Yuen, Patrick Man Pan PMP; Li, Chi-Kong CK; Leung, Alex Wing Kwan AWK; Leung, Kam Tong KT

Publication Date: 2022-11-02

Variant appearance in text: NRAS: G13R

PubMed Link: 35960210

Variant Present in the following documents:

• bcd-22-0011_supplementary_tables_suppst1-st15.xlsx, sheet 10

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Distinguishing STAT3/STAT5B Mutated Large Granular Lymphocyte Leukemia from Myeloid Neoplasms by Genetic Profiling.

Blood Advances

Kavesh, Mark M; Mohebnasab, Maedeh M; Angel, Marcela Riveros MR; Xie, Wei W; Raess, Philipp W PW; Cui, Wei W; Press, Richard D RD; Yang, Guang G; Li, Peng P

Publication Date: 2022-08-08

Variant appearance in text: NRAS: 37G>C; G13R

PubMed Link: 35939786

Variant Present in the following documents:

• BLOODA_ADV-2022-008192-mmc1.pdf

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Genomic landscape of patients with FLT3-mutated acute myeloid leukemia (AML) treated within the CALGB 10603/RATIFY trial.

Leukemia

Jahn, Nikolaus N; Jahn, Ekaterina E; Saadati, Maral M; Bullinger, Lars L; Larson, Richard A RA; Ottone, Tiziana T; Amadori, Sergio S; Prior, Thomas W TW; Brandwein, Joseph M JM; Appelbaum, Frederick R FR; Medeiros, Bruno C BC; Tallman, Martin S MS; Ehninger, Gerhard G; Heuser, Michael M; Ganser, Arnold A; Pallaud, Celine C; Gathmann, Insa I; Krzykalla, Julia J; Benner, Axel A; Bloomfield, Clara D CD; Thiede, Christian C; Stone, Richard M RM; Döhner, Hartmut H; Döhner, Konstanze K

Publication Date: 2022-09

Variant appearance in text: NRAS: G13R; rs121434595

PubMed Link: 35922444

Variant Present in the following documents:

• 41375_2022_1650_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Clonal Evolution at First Sight: A Combined Visualization of Diverse Diagnostic Methods Improves Understanding of Leukemic Progression.

Frontiers In Oncology

Sandmann, Sarah S; Behrens, Yvonne Lisa YL; Davenport, Claudia C; Thol, Felicitas F; Heuser, Michael M; Dörfel, Daniela D; Löhr, Friederike F; Castrup, Agnes A; Steinemann, Doris D; Varghese, Julian J; Schlegelberger, Brigitte B; Dugas, Martin M; Göhring, Gudrun G

Publication Date: 2022

Variant appearance in text: NRAS: 37G>C; Gly13Arg

PubMed Link: 35875134

Variant Present in the following documents:

• Table_1.xlsx, sheet 1

View BVdb publication page

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Analysis of KRAS, NRAS, and BRAF Mutations, Microsatellite Instability, and Relevant Prognosis Effects in Patients With Early Colorectal Cancer: A Cohort Study in East Asia.

Frontiers In Oncology

Li, Yang Y; Xiao, Jun J; Zhang, Tiancheng T; Zheng, Yanying Y; Jin, Hailin H

Publication Date: 2022

Variant appearance in text: NRAS: G13R

PubMed Link: 35837115

Variant Present in the following documents:

• Main text
• fonc-12-897548.pdf

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Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.

Nature Genetics

Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS

Publication Date: 2022-08

Variant appearance in text: NRAS: G13R

PubMed Link: 35835912

Variant Present in the following documents:

• 41588_2022_1121_MOESM3_ESM.xlsx, sheet 2

View BVdb publication page

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Correlation of changes in subclonal architecture with progression in the MMRF CoMMpass study.

Translational Oncology

Kaur, Gurvinder G; Jena, Lingaraja L; Gupta, Ritu R; Farswan, Akanksha A; Gupta, Anubha A; Sriram, K K

Publication Date: 2022-06-28

Variant appearance in text: NRAS: 37G>C; Gly13Arg

PubMed Link: 35777247

Variant Present in the following documents:

• mmc5.xls, sheet 3

View BVdb publication page

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The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma.

Nature Communications

Vo, Josh N JN; Wu, Yi-Mi YM; Mishler, Jeanmarie J; Hall, Sarah S; Mannan, Rahul R; Wang, Lisha L; Ning, Yu Y; Zhou, Jin J; Hopkins, Alexander C AC; Estill, James C JC; Chan, Wallace K B WKB; Yesil, Jennifer J; Cao, Xuhong X; Rao, Arvind A; Tsodikov, Alexander A; Talpaz, Moshe M; Cole, Craig E CE; Ye, Jing C JC; , ; Bergsagel, P Leif PL; Auclair, Daniel D; Cho, Hearn Jay HJ; Robinson, Dan R DR; Chinnaiyan, Arul M AM

Publication Date: 2022-06-29

Variant appearance in text: NRAS: 37G>C; Gly13Arg; rs121434595

PubMed Link: 35768438

Variant Present in the following documents:

• 41467_2022_31430_MOESM4_ESM.xlsx, sheet 1

View BVdb publication page

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Heterogeneity in Melanoma.

Cancers

Ng, Mei Fong MF; Simmons, Jacinta L JL; Boyle, Glen M GM

Publication Date: 2022-06-20

Variant appearance in text: NRAS: G13R

PubMed Link: 35740696

Variant Present in the following documents:

• Main text

View BVdb publication page

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Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.

Nature Communications

Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX

Publication Date: 2022-06-15

Variant appearance in text: NRAS: G13R

PubMed Link: 35705558

Variant Present in the following documents:

• 41467_2022_30496_MOESM2_ESM.xls, sheet 1

View BVdb publication page

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Next-generation sequencing in advanced Chinese melanoma reveals therapeutic targets and prognostic biomarkers for immunotherapy.

Scientific Reports

Huang, Fuxue F; Li, Jingjing J; Wen, Xizhi X; Zhu, Baoyan B; Liu, Wei W; Wang, Jiuhong J; Jiang, Hang H; Ding, Ya Y; Li, Dandan D; Zhang, Xiaoshi X

Publication Date: 2022-06-10

Variant appearance in text: NRAS: 37G>C; G13R; rs121434595

PubMed Link: 35688842

Variant Present in the following documents:

• 41598_2022_13391_MOESM5_ESM.xlsx, sheet 2

View BVdb publication page

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Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation.

Nature Communications

Murphy, Brandon M BM; Terrell, Elizabeth M EM; Chirasani, Venkat R VR; Weiss, Tirzah J TJ; Lew, Rachel E RE; Holderbaum, Andrea M AM; Dhakal, Aastha A; Posada, Valentina V; Fort, Marie M; Bodnar, Michael S MS; Carey, Leiah M LM; Chen, Min M; Burd, Craig J CJ; Coppola, Vincenzo V; Morrison, Deborah K DK; Campbell, Sharon L SL; Burd, Christin E CE

Publication Date: 2022-06-07

Variant appearance in text: NRAS: G13R

PubMed Link: 35672316

Variant Present in the following documents:

• 41467_2022_30881_MOESM8_ESM.xlsx, sheet 18
• 41467_2022_30881_MOESM8_ESM.xlsx, sheet 17

View BVdb publication page

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Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence.

Leukemia

Misund, Kristine K; Hofste Op Bruinink, Davine D; Coward, Eivind E; Hoogenboezem, Remco M RM; Rustad, Even Holth EH; Sanders, Mathijs A MA; Rye, Morten M; Sponaas, Anne-Marit AM; van der Holt, Bronno B; Zweegman, Sonja S; Hovig, Eivind E; Meza-Zepeda, Leonardo A LA; Sundan, Anders A; Myklebost, Ola O; Sonneveld, Pieter P; Waage, Anders A

Publication Date: 2022-07

Variant appearance in text: NRAS: G13R

PubMed Link: 35643867

Variant Present in the following documents:

• 41375_2022_1597_MOESM3_ESM.xlsx, sheet 7
• 41375_2022_1597_MOESM4_ESM.xlsx, sheet 1

View BVdb publication page

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Construction and validation of an immunoediting-based optimized neoantigen load (ioTNL) model to predict the response and prognosis of immune checkpoint therapy in various cancers.

Aging

Su, Xiaofan X; Jin, Haoxuan H; Wang, Jiaqian J; Lu, Huiping H; Gu, Tiantian T; Gao, Zhibo Z; Li, Manxiang M

Publication Date: 2022-05-25

Variant appearance in text: NRAS: 37G>C; G13R

PubMed Link: 35613927

Variant Present in the following documents:

• aging-14-204101-s004.xlsx, sheet 1

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A bipartite graph-based expected networks approach identifies DDR genes not associated with TMB yet predictive of immune checkpoint blockade response.

Cell Reports. Medicine

Weir, William H WH; Mucha, Peter J PJ; Kim, William Y WY

Publication Date: 2022-05-17

Variant appearance in text: NRAS: 37G>C; Gly13Arg

PubMed Link: 35584624

Variant Present in the following documents:

• mmc2.xlsx, sheet 4

View BVdb publication page

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Lenalidomide promotes the development of TP53-mutated therapy-related myeloid neoplasms.

Blood

Sperling, Adam S AS; Guerra, Veronica A VA; Kennedy, James A JA; Yan, Yuanqing Y; Hsu, Joanne I JI; Wang, Feng F; Nguyen, Andrew T AT; Miller, Peter G PG; McConkey, Marie E ME; Quevedo Barrios, Vanessa A VA; Furudate, Ken K; Zhang, Linda L; Kanagal-Shamanna, Rashmi R; Zhang, Jianhua J; Little, Latasha L; Gumbs, Curtis C; Daver, Naval N; DiNardo, Courtney D CD; Kadia, Tapan T; Ravandi, Farhad F; Kantarjian, Hagop H; Garcia-Manero, Guillermo G; Futreal, P Andrew PA; Ebert, Benjamin L BL; Takahashi, Koichi K

Publication Date: 2022-10-20

Variant appearance in text: NRAS: G13R

PubMed Link: 35512188

Variant Present in the following documents:

• BLOOD_BLD-2021-014956-mmc1.pdf

View BVdb publication page

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Paclitaxel and cisplatin with or without cetuximab in metastatic esophageal squamous cell carcinoma: a randomized, multicenter phase II trial.

Innovation (Cambridge (Mass.))

Lu, Zhihao Z; Zhang, Yanqiao Y; Fan, Qingxia Q; Pan, Yueyin Y; Jiang, Da D; Lu, Ping P; Zhang, Jingdong J; Yuan, Xianglin X; Feng, Jifeng J; Yang, Shujun S; Yue, Wenbin W; Zhao, Lin L; Xu, Yunhua Y; Luo, Jinhua J; Shen, Lin L

Publication Date: 2022-05-10

Variant appearance in text: NRAS: 37G>C; G13R

PubMed Link: 35509869

Variant Present in the following documents:

• mmc2.xlsx, sheet 1

View BVdb publication page

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An alternative CYB5A transcript is expressed in aneuploid ALL and enriched in relapse.

Bmc Genomic Data

Bartsch, Lorenz L; Schroeder, Michael P MP; Hänzelmann, Sonja S; Bastian, Lorenz L; Lázaro-Navarro, Juan J; Schlee, Cornelia C; Tanchez, Jutta Ortiz JO; Schulze, Veronika V; Isaakidis, Konstandina K; Rieger, Michael A MA; Gökbuget, Nicola N; Eckert, Cornelia C; Serve, Hubert H; Horstmann, Martin M; Schrappe, Martin M; Brüggemann, Monika M; Baldus, Claudia D CD; Neumann, Martin M

Publication Date: 2022-04-18

Variant appearance in text: NRAS: G13R; rs121434595

PubMed Link: 35436854

Variant Present in the following documents:

• 12863_2022_1041_MOESM15_ESM.xlsx, sheet 2

View BVdb publication page

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Mature plasmacytoid dendritic cells associated with acute myeloid leukemia show similar genetic mutations and expression profiles to leukemia cells.

Blood Science (Baltimore, Md.)

Gong, Xiaoyuan X; Li, Chunhong C; Wang, Ying Y; Rao, Qing Q; Mi, Yingchang Y; Wang, Min M; Wei, Hui H; Wang, Jianxiang J

Publication Date: 2022-01

Variant appearance in text: NRAS: G13R

PubMed Link: 35399539

Variant Present in the following documents:

• Main text
• bls-4-38-s005.pdf
• bls-4-38.pdf

View BVdb publication page

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