Publications:

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Alteration in molecular properties during establishment and passaging of endometrial carcinoma patient-derived xenografts.

Scientific Reports

Imai, Toshio T; Yoshida, Hiroshi H; Machida, Yukino Y; Kuramochi, Mizuki M; Ichikawa, Hitoshi H; Kubo, Takashi T; Takahashi, Mami M; Kato, Tomoyasu T

Publication Date: 2023-05-25

Variant appearance in text: POLE: V411L

PubMed Link: 37231035

Variant Present in the following documents:

• Main text
• 41598_2023_Article_35703.pdf
• 41598_2023_35703_MOESM1_ESM.pdf

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Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Nature Communications

Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA

Publication Date: 2023-04-03

Variant appearance in text: POLE: V411L

PubMed Link: 37012232

Variant Present in the following documents:

• 41467_2023_37547_MOESM12_ESM.xlsx, sheet 2
• 41467_2023_37547_MOESM10_ESM.xlsx, sheet 3

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Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: POLE: 1231G>T; Val411Leu

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

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Pan-cancer clinical impact of latent drivers from double mutations.

Communications Biology

Yavuz, Bengi Ruken BR; Tsai, Chung-Jung CJ; Nussinov, Ruth R; Tuncbag, Nurcan N

Publication Date: 2023-02-20

Variant appearance in text: POLE: V411L

PubMed Link: 36808143

Variant Present in the following documents:

• 42003_2023_4519_MOESM3_ESM.xlsx, sheet 3

View BVdb publication page

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Utility of molecular subtypes and genetic alterations for evaluating clinical outcomes in 1029 patients with endometrial cancer.

British Journal Of Cancer

Asami, Yuka Y; Kobayashi Kato, Mayumi M; Hiranuma, Kengo K; Matsuda, Maiko M; Shimada, Yoko Y; Ishikawa, Mitsuya M; Koyama, Takafumi T; Komatsu, Masaaki M; Hamamoto, Ryuji R; Nagashima, Minoru M; Terao, Yasuhisa Y; Itakura, Atsuo A; Kohno, Takashi T; Sekizawa, Akihiko A; Matsumoto, Koji K; Kato, Tomoyasu T; Shiraishi, Kouya K; Yoshida, Hiroshi H

Publication Date: 2023-02-16

Variant appearance in text: POLE: V411L

PubMed Link: 36797358

Variant Present in the following documents:

• Main text
• 41416_2023_2203_MOESM1_ESM.pdf
• 41416_2023_Article_2203.pdf

View BVdb publication page

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Significance of logistic regression scoring model based on natural killer cell-mediated cytotoxic pathway in the diagnosis of colon cancer.

Frontiers In Immunology

Ye, Zhen Z; Zhang, Huanhuan H; Liang, Jianwei J; Yi, Shuying S; Zhan, Xianquan X

Publication Date: 2023

Variant appearance in text: POLE: V411L

PubMed Link: 36742322

Variant Present in the following documents:

• Table_7.xlsx, sheet 1

View BVdb publication page

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Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer.

Esmo Open

Koppikar, S S; Oaknin, A A; Babu, K Govind KG; Lorusso, D D; Gupta, S S; Wu, L-Y LY; Rajabto, W W; Harano, K K; Hong, S-H SH; Malik, R A RA; Strebel, H H; Aggarwal, I M IM; Lai, C-H CH; Dejthevaporn, T T; Tangjitgamol, S S; Cheng, W F WF; Chay, W Y WY; Benavides, D D; Hashim, N M NM; Moon, Y W YW; Yunokawa, M M; Anggraeni, T D TD; Wei, W W; Curigliano, G G; Maheshwari, A A; Mahantshetty, U U; Sheshadri, S S; Peters, S S; Yoshino, T T; Pentheroudakis, G G

Publication Date: 2023-01-23

Variant appearance in text: POLE: Val411Leu

PubMed Link: 36696825

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Immunologic Signatures across Molecular Subtypes and Potential Biomarkers for Sub-Stratification in Endometrial Cancer.

International Journal Of Molecular Sciences

Jiang, Fang F; Jiang, Shiyang S; Cao, Dongyan D; Mao, Mingyi M; Xiang, Yang Y

Publication Date: 2023-01-16

Variant appearance in text: POLE: V411L

PubMed Link: 36675305

Variant Present in the following documents:

• Main text
• ijms-24-01791.pdf

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Using canavanine resistance to measure mutation rates in Schizosaccharomyces pombe.

Plos One

Pai, Chen-Chun CC; Heitzer, Ellen E; Bertrand, Sibyl S; Toumazou, Sophia S; Humphrey, Timothy C TC; Kearsey, Stephen E SE

Publication Date: 2023

Variant appearance in text: POLE: V411L

PubMed Link: 36626373

Variant Present in the following documents:

• Main text
• pone.0271016.pdf

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Refining adjuvant treatment in endometrial cancer based on molecular features: the RAINBO clinical trial program.

International Journal Of Gynecological Cancer : Official Journal Of The International Gynecological Cancer Society

,

Publication Date: 2022-12-20

Variant appearance in text: POLE: 1231G>T

PubMed Link: 36600534

Variant Present in the following documents:

• ijgc-2022-004039supp001.pdf

View BVdb publication page

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The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations.

Nature Cancer

Villani, Anita A; Davidson, Scott S; Kanwar, Nisha N; Lo, Winnie W WW; Li, Yisu Y; Cohen-Gogo, Sarah S; Fuligni, Fabio F; Edward, Lisa-Monique LM; Light, Nicholas N; Layeghifard, Mehdi M; Harripaul, Ricardo R; Waldman, Larissa L; Gallinger, Bailey B; Comitani, Federico F; Brunga, Ledia L; Hayes, Reid R; Anderson, Nathaniel D ND; Ramani, Arun K AK; Yuki, Kyoko E KE; Blay, Sasha S; Johnstone, Brittney B; Inglese, Cara C; Hammad, Rawan R; Goudie, Catherine C; Shuen, Andrew A; Wasserman, Jonathan D JD; Venier, Rosemarie E RE; Eliou, Marianne M; Lorenti, Miranda M; Ryan, Carol Ann CA; Braga, Michael M; Gloven-Brown, Meagan M; Han, Jianan J; Montero, Maria M; Spatare, Famida F; Whitlock, James A JA; Scherer, Stephen W SW; Chun, Kathy K; Somerville, Martin J MJ; Hawkins, Cynthia C; Abdelhaleem, Mohamed M; Ramaswamy, Vijay V; Somers, Gino R GR; Kyriakopoulou, Lianna L; Hitzler, Johann J; Shago, Mary M; Morgenstern, Daniel A DA; Tabori, Uri U; Meyn, Stephen S; Irwin, Meredith S MS; Malkin, David D; Shlien, Adam A

Publication Date: 2022-12-30

Variant appearance in text: POLE: V411L

PubMed Link: 36585449

Variant Present in the following documents:

• 43018_2022_474_MOESM12_ESM.xlsx, sheet 6
• 43018_2022_474_MOESM12_ESM.xlsx, sheet 10
• 43018_2022_474_MOESM7_ESM.xlsx, sheet 10
• 43018_2022_474_MOESM10_ESM.xlsx, sheet 10
• 43018_2022_474_MOESM2_ESM.xlsx, sheet 6
• 43018_2022_474_MOESM2_ESM.xlsx, sheet 10
• 43018_2022_474_MOESM3_ESM.xlsx, sheet 6
• 43018_2022_474_MOESM3_ESM.xlsx, sheet 10
• 43018_2022_474_MOESM7_ESM.xlsx, sheet 6
• 43018_2022_474_MOESM10_ESM.xlsx, sheet 6

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Validation and Clinical Application of ONCOaccuPanel for Targeted Next-Generation Sequencing of Solid Tumors.

Cancer Research And Treatment

Kim, Moonsik M; Lee, Changseon C; Hong, Juyeon J; Kim, Juhee J; Jeong, Ji Yun JY; Park, Nora Jee-Young NJ; Kim, Ji-Eun JE; Park, Ji Young JY

Publication Date: 2022-11-25

Variant appearance in text: POLE: V411L

PubMed Link: 36470260

Variant Present in the following documents:

• crt-2022-891.pdf

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Endometrial Cancer in Reproductive Age: Fertility-Sparing Approach and Reproductive Outcomes.

Cancers

Mutlu, Levent L; Manavella, Diego D DD; Gullo, Giuseppe G; McNamara, Blair B; Santin, Alessandro D AD; Patrizio, Pasquale P

Publication Date: 2022-10-22

Variant appearance in text: POLE: Val411Leu

PubMed Link: 36358604

Variant Present in the following documents:

• Main text
• cancers-14-05187.pdf

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The clinicopathological characteristics of POLE-mutated/ultramutated endometrial carcinoma and prognostic value of POLE status: a meta-analysis based on 49 articles incorporating 12,120 patients.

Bmc Cancer

Wu, Qing Q; Zhang, Nianhai N; Xie, Xianhe X

Publication Date: 2022-11-10

Variant appearance in text: POLE: Val411Leu

PubMed Link: 36357827

Variant Present in the following documents:

• Main text
• 12885_2022_Article_10267.pdf

View BVdb publication page

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Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics

Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q

Publication Date: 2022-11-04

Variant appearance in text: POLE: 1231G>T; V411L

PubMed Link: 36333792

Variant Present in the following documents:

• 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1

View BVdb publication page

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Characterization of hotspot exonuclease domain mutations in the DNA polymerase ϵ gene in endometrial cancer.

Frontiers In Oncology

Tian, Wenjuan W; Ji, Zhaodong Z; Wang, Jingshu J; Meng, Jiao J; Bi, Rui R; Ren, Yulan Y; Shan, Boer B; Yang, Gong G; Wang, Huaying H

Publication Date: 2022

Variant appearance in text: POLE: V411L

PubMed Link: 36313640

Variant Present in the following documents:

• Main text
• fonc-12-1018034.pdf
• DataSheet_1.pdf

View BVdb publication page

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Pathologic complete response to immune checkpoint inhibitor in a stage IIIB ovarian clear cell carcinoma patient with POLE mutation resistant to platinum-based chemotherapy: a case report.

Gland Surgery

Li, Shuzhan S; Zhang, Jiali J; Du, Weijiao W; Ren, Xiubao X; Zhang, Xinwei X

Publication Date: 2022-09

Variant appearance in text: POLE: V411L

PubMed Link: 36221285

Variant Present in the following documents:

• Main text
• gs-11-09-1562.pdf

View BVdb publication page

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A new strategy in molecular typing: the accuracy of an NGS panel for the molecular classification of endometrial cancers.

Annals Of Translational Medicine

Li, Yang Y; Feng, Junnan J; Zhao, Chengzhi C; Meng, Lin L; Shi, Shanshan S; Liu, Kangdong K; Ma, Jie J

Publication Date: 2022-08

Variant appearance in text: POLE: 1231G>T

PubMed Link: 36111057

Variant Present in the following documents:

• Main text
• atm-10-16-870.pdf

View BVdb publication page

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Ultrasensitive tumour-agnostic non-invasive detection of colorectal cancer recurrence using ctDNA methylation.

Clinical And Translational Medicine

Xiao, Yu Y; Wang, Xiaodong X; Weng, Hong H; Ding, Zhao Z; Qian, Kaiyu K; Jin, Wan W; Lu, Sen S; Ju, Lingao L; He, Zhiwen Z; Wang, Gang G; Xie, Xiaoyu X; Liu, Dongmei D; Fan, Zhou Z; Wu, Kai K; Li, Sheng S; Guo, Huanhuan H; Qian, Guofeng G; Jiang, Wei W; Leng, Yunji Y; Zhao, Junpeng J; Cao, Xinyue X; Peng, Minsheng M; Jiang, Congqing C; Li, Li L; Zhang, Yi Y; Wang, Xinghuan X

Publication Date: 2022-09

Variant appearance in text: POLE: 1231G>T; V411L

PubMed Link: 36103400

Variant Present in the following documents:

• CTM2-12-e1015-s002.xlsx, sheet 1

View BVdb publication page

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POLE/POLD1 mutation and tumor immunotherapy.

Journal Of Experimental & Clinical Cancer Research : Cr

Ma, Xiaoting X; Dong, Lin L; Liu, Xiu X; Ou, Kai K; Yang, Lin L

Publication Date: 2022-07-02

Variant appearance in text: POLE: V411L

PubMed Link: 35780178

Variant Present in the following documents:

• Main text
• 13046_2022_Article_2422.pdf

View BVdb publication page

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Biomarker characterization in endometrial cancer in Italy: first survey data analysis.

Pathologica

Zannoni, Gian Franco GF; Santoro, Angela A; D'Alessandris, Nicoletta N; Scaglione, Giulia G; Inzani, Frediano F; Angelico, Giuseppe G; Bragantini, Emma E; Piermattei, Alessia A; Cianfrini, Federica F; Bisaro, Brigitte B; Fassan, Matteo M; ,

Publication Date: 2022-06

Variant appearance in text: POLE: V411L

PubMed Link: 35775705

Variant Present in the following documents:

• Main text
• pathol-2022-03-189.pdf

View BVdb publication page

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Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma.

The Journal Of Clinical Investigation

Lee, Patrick C PC; Klaeger, Susan S; Le, Phuong M PM; Korthauer, Keegan K; Cheng, Jingwei J; Ananthapadmanabhan, Varsha V; Frost, Thomas C TC; Stevens, Jonathan D JD; Wong, Alan Yl AY; Iorgulescu, J Bryan JB; Tarren, Anna Y AY; Chea, Vipheaviny A VA; Carulli, Isabel P IP; Lemvigh, Camilla K CK; Pedersen, Christina B CB; Gartin, Ashley K AK; Sarkizova, Siranush S; Wright, Kyle T KT; Li, Letitia W LW; Nomburg, Jason J; Li, Shuqiang S; Huang, Teddy T; Liu, Xiaoxi X; Pomerance, Lucas L; Doherty, Laura M LM; Apffel, Annie M AM; Wallace, Luke J LJ; Rachimi, Suzanna S; Felt, Kristen D KD; Wolff, Jacquelyn O JO; Witten, Elizabeth E; Zhang, Wandi W; Neuberg, Donna D; Lane, William J WJ; Zhang, Guanglan G; Olsen, Lars R LR; Thakuria, Manisha M; Rodig, Scott J SJ; Clauser, Karl R KR; Starrett, Gabriel J GJ; Doench, John G JG; Buhrlage, Sara J SJ; Carr, Steven A SA; DeCaprio, James A JA; Wu, Catherine J CJ; Keskin, Derin B DB

Publication Date: 2022-07-01

Variant appearance in text: POLE: V411L

PubMed Link: 35775490

Variant Present in the following documents:

• jci-132-151666-s199.xlsx, sheet 1

View BVdb publication page

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Collaborative Group of the Americas on Inherited Gastrointestinal Cancers (CGA-IGC) Annual Virtual Meeting, November 13-15, 2021.

Familial Cancer

Publication Date: 2022-10

Variant appearance in text: POLE: V411L

PubMed Link: 35366121

Variant Present in the following documents:

• Main text
• 10689_2021_Article_284.pdf

View BVdb publication page

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Clinicopathological and molecular characterization of high-grade endometrial carcinoma with POLE mutation: a single center study.

Journal Of Gynecologic Oncology

Yu, Shuangni S; Sun, Zezheng Z; Zong, Liju L; Yan, Jie J; Yu, Mei M; Chen, Jie J; Lu, Zhaohui Z

Publication Date: 2022-05

Variant appearance in text: POLE: V411L

PubMed Link: 35320887

Variant Present in the following documents:

• jgo-33-e38.pdf
• jgo-33-e38-s001.xls, sheet 1
• jgo-33-e38-s002.xls, sheet 1

View BVdb publication page

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Nonmalignant Features Associated with Inherited Colorectal Cancer Syndromes-Clues for Diagnosis.

Cancers

Haimov, Diana D; Lieberman, Sari S; Castellvi-Bel, Sergi S; Nielsen, Maartje M; Goldberg, Yael Y

Publication Date: 2022-01-26

Variant appearance in text: POLE: Val411Leu

PubMed Link: 35158896

Variant Present in the following documents:

• Main text
• cancers-14-00628.pdf

View BVdb publication page

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Nonmalignant Features Associated with Inherited Colorectal Cancer Syndromes-Clues for Diagnosis.

Cancers

Haimov, Diana D; Lieberman, Sari S; Castellvi-Bel, Sergi S; Nielsen, Maartje M; Goldberg, Yael Y

Publication Date: 2022-01-26

Variant appearance in text: POLE: Val411Leu

PubMed Link: 35158896

Variant Present in the following documents:

• Main text
• cancers-14-00628.pdf

View BVdb publication page

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Clinical and Molecular Characterization of POLE Mutations as Predictive Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Cancers.

Jco Precision Oncology

Garmezy, Benjamin B; Gheeya, Jinesh J; Lin, Heather Y HY; Huang, Yuefan Y; Kim, Taebeom T; Jiang, Xianli X; Thein, Kyaw Z KZ; Pilié, Patrick G PG; Zeineddine, Fadl F; Wang, Wanlin W; Shaw, Kenna R KR; Rodon, Jordi J; Shen, John Paul JP; Yuan, Ying Y; Meric-Bernstam, Funda F; Chen, Ken K; Yap, Timothy A TA

Publication Date: 2022-02

Variant appearance in text: POLE: V411L

PubMed Link: 35108036

Variant Present in the following documents:

• Main text

View BVdb publication page

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Clinical and Molecular Characterization of POLE Mutations as Predictive Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Cancers.

Jco Precision Oncology

Garmezy, Benjamin B; Gheeya, Jinesh J; Lin, Heather Y HY; Huang, Yuefan Y; Kim, Taebeom T; Jiang, Xianli X; Thein, Kyaw Z KZ; Pilié, Patrick G PG; Zeineddine, Fadl F; Wang, Wanlin W; Shaw, Kenna R KR; Rodon, Jordi J; Shen, John Paul JP; Yuan, Ying Y; Meric-Bernstam, Funda F; Chen, Ken K; Yap, Timothy A TA

Publication Date: 2022-02

Variant appearance in text: POLE: V411L

PubMed Link: 35108036

Variant Present in the following documents:

• Main text

View BVdb publication page

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Mutational landscape of primary and recurrent Ewing sarcoma.

Contemporary Oncology (Poznan, Poland)

Jagodzińska-Mucha, Paulina P; Sobczuk, Paweł P; Mikuła, Michał M; Raciborska, Anna A; Dawidowska, Anna A; Kulecka, Maria M; Bilska, Katarzyna K; Szumera-Ciećkiewicz, Anna A; Kluska, Anna A; Piątkowska, Magdalena M; Bałabas, Anna A; Rutkowski, Piotr P; Ługowska, Iwona I

Publication Date: 2021

Variant appearance in text: POLE: V411L

PubMed Link: 35079231

Variant Present in the following documents:

• Main text

View BVdb publication page

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A framework for mutational signature analysis based on DNA shape parameters.

Plos One

Karolak, Aleksandra A; Levatić, Jurica J; Supek, Fran F

Publication Date: 2022

Variant appearance in text: POLE: V411L

PubMed Link: 35015788

Variant Present in the following documents:

• pone.0262495.s010.pdf

View BVdb publication page

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A framework for mutational signature analysis based on DNA shape parameters.

Plos One

Karolak, Aleksandra A; Levatić, Jurica J; Supek, Fran F

Publication Date: 2022

Variant appearance in text: POLE: V411L

PubMed Link: 35015788

Variant Present in the following documents:

• pone.0262495.s010.pdf

View BVdb publication page

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Molecular Evaluation of Endometrial Dedifferentiated Carcinoma, Endometrioid Carcinoma, Carcinosarcoma, and Serous Carcinoma Using a Custom-Made Small Cancer Panel.

Pathology Oncology Research : Por

Kobayashi, Yusuke Y; Kitazono, Ikumi I; Akahane, Toshiaki T; Yanazume, Shintaro S; Kamio, Masaki M; Togami, Shinichi S; Nohara, Sachio S; Sakamoto, Ippei I; Yokoyama, Seiya S; Tabata, Kazuhiro K; Kobayashi, Hiroaki H; Tanimoto, Akihide A

Publication Date: 2021

Variant appearance in text: POLE: Val411Leu

PubMed Link: 35002543

Variant Present in the following documents:

• Main text
• Table4.xlsx, sheet 1

View BVdb publication page

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Clinical evaluation of a droplet digital PCR assay for detecting POLE mutations and molecular classification of endometrial cancer.

Journal Of Gynecologic Oncology

Kim, Gilhyang G; Lee, Song Kook SK; Suh, Dong Hoon DH; Kim, Kidong K; No, Jae Hong JH; Kim, Yong Beom YB; Kim, Hyojin H

Publication Date: 2022-03

Variant appearance in text: POLE: V411L

PubMed Link: 34910396

Variant Present in the following documents:

• jgo-33-e15.pdf

View BVdb publication page

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Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer.

Nature Cancer

Westcott, Peter M K PMK; Sacks, Nathan J NJ; Schenkel, Jason M JM; Ely, Zackery A ZA; Smith, Olivia O; Hauck, Haley H; Jaeger, Alex M AM; Zhang, Daniel D; Backlund, Coralie M CM; Beytagh, Mary C MC; Patten, J J JJ; Elbashir, Ryan R; Eng, George G; Irvine, Darrell J DJ; Yilmaz, Omer H OH; Jacks, Tyler T

Publication Date: 2021-10

Variant appearance in text: POLE: 1231G>T; Val411Leu

PubMed Link: 34738089

Variant Present in the following documents:

• NIHMS1725490-supplement-Source_Data_Figure_1.xlsx, sheet 1

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: POLE: V411L

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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Distinct mutational profile and immune microenvironment in microsatellite-unstable and POLE-mutated tumors.

Journal For Immunotherapy Of Cancer

Hwang, Hee Sang HS; Kim, Deokhoon D; Choi, Jene J

Publication Date: 2021-10

Variant appearance in text: POLE: V411L

PubMed Link: 34607897

Variant Present in the following documents:

• Main text
• jitc-2021-002797.pdf

View BVdb publication page

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POLE/POLD1 mutation in non-exonuclease domain matters for predicting efficacy of immune-checkpoint-inhibitor therapy.

Clinical And Translational Medicine

Chen, Yan-Xing YX; Wang, Zi-Xian ZX; Yuan, Shu-Qiang SQ; Jiang, Teng-Jia TJ; Huang, You-Sheng YS; Xu, Rui-Hua RH; Wang, Feng F; Zhao, Qi Q

Publication Date: 2021-09

Variant appearance in text: POLE: V411L

PubMed Link: 34586735

Variant Present in the following documents:

• CTM2-11-e524-s001.xlsx, sheet 2
• CTM2-11-e524-s001.xlsx, sheet 6

View BVdb publication page

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Tumor BRCA testing can reveal a high tumor mutational burden related to POLE pathogenic variants.

Gynecologic Oncology Reports

Villy, M-C MC; Masliah-Planchon, J J; Melaabi, S S; Trabelsi Grati, O O; Girard, E E; Bataillon, G G; Vincent-Salomon, A A; Le Gall, J J; Golmard, L L; Stoppa-Lyonnet, D D; Bieche, I I; Colas, C C

Publication Date: 2021-08

Variant appearance in text: POLE: 1231G>T; Val411Leu

PubMed Link: 34541275

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic mutations associated with sensitivity to neoadjuvant chemotherapy in metastatic colon cancer: A case report and review of literature.

World Journal Of Clinical Cases

Zhao, Long L; Wang, Quan Q; Zhao, Shi-Dong SD; Zhou, Jing J; Jiang, Ke-Wei KW; Ye, Ying-Jiang YJ; Wang, Shan S; Shen, Zhan-Long ZL

Publication Date: 2021-08-26

Variant appearance in text: POLE: V411L

PubMed Link: 34540965

Variant Present in the following documents:

• Main text
• WJCC-9-7099.pdf

View BVdb publication page

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Adjuvant Treatment Recommendations in Early-Stage Endometrial Cancer: What Changes With the Introduction of The Integrated Molecular-Based Risk Assessment.

Frontiers In Oncology

Nero, Camilla C; Ciccarone, Francesca F; Pietragalla, Antonella A; Duranti, Simona S; Daniele, Gennaro G; Scambia, Giovanni G; Lorusso, Domenica D

Publication Date: 2021

Variant appearance in text: POLE: V411L

PubMed Link: 34540651

Variant Present in the following documents:

• Main text

View BVdb publication page

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Additive effects of variants of unknown significance in replication repair-associated DNA polymerase genes on mutational burden and prognosis across diverse cancers.

Journal For Immunotherapy Of Cancer

Ying, Jieer J; Yang, Lin L; Yin, Jiani C JC; Xia, Guojie G; Xing, Minyan M; Chen, Xiaoxi X; Pang, Jiaohui J; Wu, Yong Y; Bao, Hua H; Wu, Xue X; Shao, Yang Y; Zhu, Lingjun L; Cheng, Xiangdong X

Publication Date: 2021-09

Variant appearance in text: POLE: V411L

PubMed Link: 34479923

Variant Present in the following documents:

• Main text
• jitc-2021-002336.pdf

View BVdb publication page

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