Publications:

---

Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape.

Biorxiv : The Preprint Server For Biology

Ratnasinghe, Brian D BD; Haque, Neshatul N; Wagenknecht, Jessica B JB; Jensen, Davin R DR; Esparza, Guadalupe V GV; Leverence, Elise N EN; De Assuncao, Thiago Milech TM; Mathison, Angela J AJ; Lomberk, Gwen G; Smith, Brian C BC; Volkman, Brian F BF; Urrutia, Raul R; Zimmermann, Michael T MT

Publication Date: 2023-04-28

Variant appearance in text: KRAS: Q61E

PubMed Link: 37207265

Variant Present in the following documents:

• Main text
• nihpp-2023.04.28.536249v1.pdf

View BVdb publication page

---

Recapitulating thyroid cancer histotypes through engineering embryonic stem cells.

Nature Communications

Veschi, Veronica V; Turdo, Alice A; Modica, Chiara C; Verona, Francesco F; Di Franco, Simone S; Gaggianesi, Miriam M; Tirrò, Elena E; Di Bella, Sebastiano S; Iacono, Melania Lo ML; Pantina, Vincenzo Davide VD; Porcelli, Gaetana G; Mangiapane, Laura Rosa LR; Bianca, Paola P; Rizzo, Aroldo A; Sciacca, Elisabetta E; Pillitteri, Irene I; Vella, Veronica V; Belfiore, Antonino A; Bongiorno, Maria Rita MR; Pistone, Giuseppe G; Memeo, Lorenzo L; Colarossi, Lorenzo L; Giuffrida, Dario D; Colarossi, Cristina C; Vigneri, Paolo P; Todaro, Matilde M; Stassi, Giorgio G

Publication Date: 2023-03-11

Variant appearance in text: KRAS: Q61E; rs121913238

PubMed Link: 36906579

Variant Present in the following documents:

• 41467_2023_36922_MOESM4_ESM.xls, sheet 2

View BVdb publication page

---

In Silico Evaluation of the Thr58-Associated Conserved Water with KRAS Switch-II Pocket Binders.

Journal Of Chemical Information And Modeling

Leini, Renne R; Pantsar, Tatu T

Publication Date: 2023-02-28

Variant appearance in text: KRAS: Q61E

PubMed Link: 36854010

Variant Present in the following documents:

• ci2c01479_si_002.xlsx, sheet 1

View BVdb publication page

---

Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: KRAS: 181C>G; Gln61Glu

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

View BVdb publication page

---

Dynamics of age- versus therapy-related clonal hematopoiesis in long-term survivors of pediatric cancer.

Cancer Discovery

Hagiwara, Kohei K; Natarajan, Sivaraman S; Wang, Zhaoming Z; Zubair, Haseeb H; Mulder, Heather L HL; Dong, Li L; Plyler, Emily M EM; Thimmaiah, Padma P; Ma, Xiaotu X; Ness, Kirsten K KK; Li, Zhenghong Z; Mulrooney, Daniel A DA; Wilson, Carmen L CL; Yasui, Yutaka Y; Hudson, Melissa M MM; Easton, John J; Robison, Leslie L LL; Zhang, Jinghui J

Publication Date: 2023-02-08

Variant appearance in text: KRAS: Q61E

PubMed Link: 36751942

Variant Present in the following documents:

• cd-22-0956_tables_s2_s7_s8_s9_suppst1.xlsx, sheet 1
• cd-22-0956_tables_s2_s7_s8_s9_suppst1.xlsx, sheet 4

View BVdb publication page

---

Prevalence and patterns of mutations in RAS/RAF/MEK/ERK/MAPK signaling pathway in colorectal cancer in North Africa.

Bmc Cancer

Jafari, Meryem M; Laraqui, Abdelilah A; Baba, Walid W; Benmokhtar, Soukaina S; Zaitouni, Sara El SE; Ali, Abdelmounaim Ait AA; Bounaim, Ahmed A; Moujahid, Mountassir M; Tanz, Rachid R; Mahfoud, Tarik T; Sbitti, Yassir Y; Annaz, Hicham El HE; Abi, Rachid R; Tagajdid, Mohamed Rida MR; Kochri, Safae El SE; Lahlou, Idriss Amine IA; Hsaini, Houda El HE; Belayachi, Lamiae L; Benjouad, Abdelaziz A; Ichou, Mohammed M; En-Nya, Amina A; Ennibi, Khalid K

Publication Date: 2022-11-07

Variant appearance in text: KRAS: 181C>G

PubMed Link: 36344948

Variant Present in the following documents:

• Main text
• 12885_2022_Article_10235.pdf

View BVdb publication page

---

Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma.

Nature Communications

Yang, Yandan Y; Bolomsky, Arnold A; Oellerich, Thomas T; Chen, Ping P; Ceribelli, Michele M; Häupl, Björn B; Wright, George W GW; Phelan, James D JD; Huang, Da Wei DW; Lord, James W JW; Van Winkle, Callie K CK; Yu, Xin X; Wisniewski, Jan J; Wang, James Q JQ; Tosto, Frances A FA; Beck, Erin E; Wilson, Kelli K; McKnight, Crystal C; Travers, Jameson J; Klumpp-Thomas, Carleen C; Smith, Grace A GA; Pittaluga, Stefania S; Maric, Irina I; Kazandjian, Dickran D; Thomas, Craig J CJ; Young, Ryan M RM

Publication Date: 2022-09-17

Variant appearance in text: KRAS: Q61E

PubMed Link: 36115844

Variant Present in the following documents:

• 41467_2022_33142_MOESM3_ESM.xlsx, sheet 29

View BVdb publication page

---

Molecular Biology and Therapeutic Perspectives for K-Ras Mutant Non-Small Cell Lung Cancers.

Cancers

Cekani, Elona E; Epistolio, Samantha S; Dazio, Giulia G; Cefalì, Marco M; Wannesson, Luciano L; Frattini, Milo M; Froesch, Patrizia P

Publication Date: 2022-08-24

Variant appearance in text: KRAS: 181C>G; Q61E

PubMed Link: 36077640

Variant Present in the following documents:

• cancers-14-04103.pdf

View BVdb publication page

---

Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology

Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M

Publication Date: 2022

Variant appearance in text: KRAS: 181C>G; Q61E

PubMed Link: 35936718

Variant Present in the following documents:

• Table_4.xlsx, sheet 2

View BVdb publication page

---

Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial.

Nature Medicine

Sartore-Bianchi, Andrea A; Pietrantonio, Filippo F; Lonardi, Sara S; Mussolin, Benedetta B; Rua, Francesco F; Crisafulli, Giovanni G; Bartolini, Alice A; Fenocchio, Elisabetta E; Amatu, Alessio A; Manca, Paolo P; Bergamo, Francesca F; Tosi, Federica F; Mauri, Gianluca G; Ambrosini, Margherita M; Daniel, Francesca F; Torri, Valter V; Vanzulli, Angelo A; Regge, Daniele D; Cappello, Giovanni G; Marchiò, Caterina C; Berrino, Enrico E; Sapino, Anna A; Marsoni, Silvia S; Siena, Salvatore S; Bardelli, Alberto A

Publication Date: 2022-08

Variant appearance in text: KRAS: Q61E

PubMed Link: 35915157

Variant Present in the following documents:

• 41591_2022_1886_MOESM1_ESM.pdf

View BVdb publication page

---

Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.

Nature Genetics

Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS

Publication Date: 2022-08

Variant appearance in text: KRAS: Q61E

PubMed Link: 35835912

Variant Present in the following documents:

• 41588_2022_1121_MOESM3_ESM.xlsx, sheet 2

View BVdb publication page

---

Correlation of changes in subclonal architecture with progression in the MMRF CoMMpass study.

Translational Oncology

Kaur, Gurvinder G; Jena, Lingaraja L; Gupta, Ritu R; Farswan, Akanksha A; Gupta, Anubha A; Sriram, K K

Publication Date: 2022-06-28

Variant appearance in text: KRAS: 181C>G; Gln61Glu

PubMed Link: 35777247

Variant Present in the following documents:

• mmc5.xls, sheet 3

View BVdb publication page

---

The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma.

Nature Communications

Vo, Josh N JN; Wu, Yi-Mi YM; Mishler, Jeanmarie J; Hall, Sarah S; Mannan, Rahul R; Wang, Lisha L; Ning, Yu Y; Zhou, Jin J; Hopkins, Alexander C AC; Estill, James C JC; Chan, Wallace K B WKB; Yesil, Jennifer J; Cao, Xuhong X; Rao, Arvind A; Tsodikov, Alexander A; Talpaz, Moshe M; Cole, Craig E CE; Ye, Jing C JC; , ; Bergsagel, P Leif PL; Auclair, Daniel D; Cho, Hearn Jay HJ; Robinson, Dan R DR; Chinnaiyan, Arul M AM

Publication Date: 2022-06-29

Variant appearance in text: KRAS: 181C>G; Gln61Glu; rs121913238

PubMed Link: 35768438

Variant Present in the following documents:

• 41467_2022_31430_MOESM4_ESM.xlsx, sheet 1

View BVdb publication page

---

Molecular Signatures of KRAS-Mutated Lung Adenocarcinoma: Analysis of Concomitant EGFR, ALK, STK11, and PD-L1 Status.

Clinical Pathology (Thousand Oaks, Ventura County, Calif.)

Hsu, Jim J; Annunziata, Joseph F JF; Burns, Ethan E; Bernicker, Eric H EH; Olsen, Randall J RJ; Thomas, Jessica S JS

Publication Date: 2022

Variant appearance in text: KRAS: Q61E

PubMed Link: 35634237

Variant Present in the following documents:

• Main text
• 10.1177_2632010X221102054.pdf

View BVdb publication page

---

Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity.

Npj Precision Oncology

Kim, Jihyun J; Park, Charny C; Kim, Kwang H KH; Kim, Eun Hye EH; Kim, Hyunki H; Woo, Jong Kyu JK; Seong, Je Kyung JK; Nam, Ki Taek KT; Lee, Yong Chan YC; Cho, Soo Young SY

Publication Date: 2022-01-27

Variant appearance in text: rs121913238

PubMed Link: 35087207

Variant Present in the following documents:

• 41698_2022_251_MOESM1_ESM.pdf

View BVdb publication page

---

Clinical Utility of Plasma-Based Comprehensive Molecular Profiling in Advanced Non-Small-Cell Lung Cancer.

Jco Precision Oncology

Schouten, Robert D RD; Vessies, Daan C L DCL; Bosch, Linda J W LJW; Barlo, Nicole P NP; van Lindert, Anne S R ASR; Cillessen, Saskia A G M SAGM; van den Broek, Daan D; van den Heuvel, Michel M MM; Monkhorst, Kim K

Publication Date: 2021-07

Variant appearance in text: KRAS: Q61E

PubMed Link: 34632253

Variant Present in the following documents:

• po-5-1112.pdf

View BVdb publication page

---

Clinical Utility of Plasma-Based Comprehensive Molecular Profiling in Advanced Non-Small-Cell Lung Cancer.

Jco Precision Oncology

Schouten, Robert D RD; Vessies, Daan C L DCL; Bosch, Linda J W LJW; Barlo, Nicole P NP; van Lindert, Anne S R ASR; Cillessen, Saskia A G M SAGM; van den Broek, Daan D; van den Heuvel, Michel M MM; Monkhorst, Kim K

Publication Date: 2021-07

Variant appearance in text: KRAS: Q61E

PubMed Link: 34632253

Variant Present in the following documents:

• po-5-1112.pdf

View BVdb publication page

---

Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: KRAS: Q61E

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

---

Outcomes and prognostic contributors in patients with KRAS mutated non-small cell pulmonary adenocarcinomas: a single institution experience.

Journal Of Thoracic Disease

Burns, Ethan A EA; Ensor, Joe E JE; Hsu, Jim J; Thomas, Jessica S JS; Olsen, Randall J RJ; Bernicker, Eric H EH

Publication Date: 2021-08

Variant appearance in text: KRAS: Q61E

PubMed Link: 34527319

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Characterization of Non-Small-Cell Lung Cancers With MET Exon 14 Skipping Alterations Detected in Tissue or Liquid: Clinicogenomics and Real-World Treatment Patterns.

Jco Precision Oncology

Lee, Jessica K JK; Madison, Russell R; Classon, Anthony A; Gjoerup, Ole O; Rosenzweig, Mark M; Frampton, Garrett M GM; Alexander, Brian M BM; Oxnard, Geoffrey R GR; Venstrom, Jeffrey M JM; Awad, Mark M MM; Schrock, Alexa B AB

Publication Date: 2021

Variant appearance in text: KRAS: Q61E

PubMed Link: 34476332

Variant Present in the following documents:

• po-5-po.21.00122.pdf

View BVdb publication page

---

Comparison of two targeted ultra-deep sequencing technologies for analysis of plasma circulating tumour DNA in endocrine-therapy-resistant breast cancer patients.

Breast Cancer Research And Treatment

Nteliopoulos, Georgios G; Page, Karen K; Hills, Allison A; Howarth, Karen K; Emmett, Warren W; Green, Emma E; Martinson, Luke J LJ; Fernadez-Garcia, Daniel D; Hastings, Robert R; Guttery, David S DS; Kenny, Laura L; Stebbing, Justin J; Cleator, Susan S; Rehman, Farah F; Gleason, Kelly L T KLT; Sanela, Andrijac A; Ion, Charlotte C; Rushton, Amelia J AJ; Rosenfeld, Nitzan N; Coombes, R Charles RC; Shaw, Jacqueline A JA

Publication Date: 2021-07

Variant appearance in text: KRAS: Q61E

PubMed Link: 34097174

Variant Present in the following documents:

• 10549_2021_6220_MOESM2_ESM.xlsx, sheet 1
• 10549_2021_6220_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

---

Clinical and prognostic features of patients with detailed RAS/BRAF-mutant colorectal cancer in Japan.

Bmc Cancer

Ikoma, Tatsuki T; Shimokawa, Mototsugu M; Kotaka, Masahito M; Matsumoto, Toshihiko T; Nagai, Hiroki H; Boku, Shogen S; Shibata, Nobuhiro N; Yasui, Hisateru H; Satake, Hironaga H

Publication Date: 2021-05-07

Variant appearance in text: KRAS: Q61E

PubMed Link: 33962575

Variant Present in the following documents:

• Main text

View BVdb publication page

---

The origins and genetic interactions of KRAS mutations are allele- and tissue-specific.

Nature Communications

Cook, Joshua H JH; Melloni, Giorgio E M GEM; Gulhan, Doga C DC; Park, Peter J PJ; Haigis, Kevin M KM

Publication Date: 2021-03-22

Variant appearance in text: KRAS: Q61E

PubMed Link: 33753749

Variant Present in the following documents:

• 41467_2021_22125_MOESM4_ESM.xlsx, sheet 4

View BVdb publication page

---

Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer

Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA

Publication Date: 2021-05

Variant appearance in text: KRAS: 181C>G; Q61E

PubMed Link: 33704917

Variant Present in the following documents:

• TCA-12-1271-s003.xls, sheet 1

View BVdb publication page

---

Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: KRAS: 181C>G; Q61E

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

---

Mass Spectrometry as a Highly Sensitive Method for Specific Circulating Tumor DNA Analysis in NSCLC: A Comparison Study.

Cancers

Lamy, Pierre-Jean PJ; van der Leest, Paul P; Lozano, Nicolas N; Becht, Catherine C; Duboeuf, Frédérique F; Groen, Harry J M HJM; Hilgers, Werner W; Pourel, Nicolas N; Rifaela, Naomi N; Schuuring, Ed E; Alix-Panabières, Catherine C

Publication Date: 2020-10-16

Variant appearance in text: KRAS: 181C>G; Q61E

PubMed Link: 33081150

Variant Present in the following documents:

• cancers-12-03002-s001.pdf

View BVdb publication page

---

Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports

Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O

Publication Date: 2020-10-13

Variant appearance in text: rs121913238

PubMed Link: 33051506

Variant Present in the following documents:

• 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

---

Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports

Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA

Publication Date: 2020-09-21

Variant appearance in text: KRAS: Q61E

PubMed Link: 32958805

Variant Present in the following documents:

• 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

---

Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine

Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y

Publication Date: 2020-08-01

Variant appearance in text: KRAS: 181C>G

PubMed Link: 32738923

Variant Present in the following documents:

• 12967_2020_2449_MOESM1_ESM.xlsx, sheet 1

View BVdb publication page

---

Identification of relevant genetic alterations in cancer using topological data analysis.

Nature Communications

Rabadán, Raúl R; Mohamedi, Yamina Y; Rubin, Udi U; Chu, Tim T; Alghalith, Adam N AN; Elliott, Oliver O; Arnés, Luis L; Cal, Santiago S; Obaya, Álvaro J ÁJ; Levine, Arnold J AJ; Cámara, Pablo G PG

Publication Date: 2020-07-30

Variant appearance in text: KRAS: Q61E

PubMed Link: 32732999

Variant Present in the following documents:

• 41467_2020_17659_MOESM3_ESM.xls, sheet 1

View BVdb publication page

---

Study of Ras Mutations' Prognostic Value in Metastatic Colorectal Cancer: STORIA Analysis.

Cancers

Ottaiano, Alessandro A; Normanno, Nicola N; Facchini, Sergio S; Cassata, Antonino A; Nappi, Anna A; Romano, Carmela C; Silvestro, Lucrezia L; De Stefano, Alfonso A; Rachiglio, Anna Maria AM; Roma, Cristin C; Maiello, Monica R MR; Scala, Stefania S; Delrio, Paolo P; Tatangelo, Fabiana F; Di Mauro, Annabella A; Botti, Gerardo G; Avallone, Antonio A; Nasti, Guglielmo G

Publication Date: 2020-07-16

Variant appearance in text: KRAS: Q61E

PubMed Link: 32708575

Variant Present in the following documents:

• cancers-12-01919.pdf

View BVdb publication page

---

miRNAs-Based Molecular Signature for KRAS Mutated and Wild Type Colorectal Cancer: An Explorative Study.

Journal Of Immunology Research

Milanesi, Elena E; Dobre, Maria M; Bucuroiu, Alina Ioana AI; Herlea, Vlad V; Manuc, Teodora Ecaterina TE; Salvi, Alessandro A; De Petro, Giuseppina G; Manuc, Mircea M; Becheanu, Gabriel G

Publication Date: 2020

Variant appearance in text: KRAS: Q61E

PubMed Link: 32676506

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Immunohistochemistry-Based Taxonomical Classification of Bladder Cancer Predicts Response to Neoadjuvant Chemotherapy.

Cancers

Font, Albert A; Domènech, Montserrat M; Benítez, Raquel R; Rava, Marta M; Marqués, Miriam M; Ramírez, José L JL; Pineda, Silvia S; Domínguez-Rodríguez, Sara S; Gago, José L JL; Badal, Josep J; Carrato, Cristina C; López, Héctor H; Quer, Ariadna A; Castellano, Daniel D; Malats, Núria N; Real, Francisco X FX

Publication Date: 2020-07-03

Variant appearance in text: KRAS: Q61E

PubMed Link: 32635360

Variant Present in the following documents:

• Main text
• cancers-12-01784.pdf

View BVdb publication page

---

Tumor Location Is Associated With the Prevalence of Braf And Pik3ca Mutations in Patients with Wild-Type Ras Colorectal Cancer: A Prospective Multi-Center Cohort Study in Japan.

Translational Oncology

Taniguchi, Hiroya H; Uehara, Keisuke K; Nakayama, Goro G; Nakayama, Hiroshi H; Aiba, Toshisada T; Hattori, Norifumi N; Kataoka, Masato M; Nakano, Yasuyuki Y; Kawase, Yoshihisa Y; Okochi, Osamu O; Matsuoka, Hiroshi H; Utsunomiya, Setsuo S; Sakamoto, Eiji E; Mori, Yoshinori Y; Umeda, Shinichi S; Shikano, Toshio T; Komori, Koji K; Tajika, Masahiro M; Kadowaki, Shigenori S; Muro, Kei K; Yatabe, Yasushi Y

Publication Date: 2020-07

Variant appearance in text: KRAS: Q61E

PubMed Link: 32428838

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

---

Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: KRAS: Q61E

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

View BVdb publication page

---

Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology

Dong, Xiaobao X; Huang, Dandan D; Yi, Xianfu X; Zhang, Shijie S; Wang, Zhao Z; Yan, Bin B; Chung Sham, Pak P; Chen, Kexin K; Jun Li, Mulin M

Publication Date: 2020-01-07

Variant appearance in text: KRAS: 181C>G; Q61E

PubMed Link: 31925297

Variant Present in the following documents:

• 42003_2019_736_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

---

Chemoenzymatic Semisynthesis of Proteins.

Chemical Reviews

Thompson, Robert E RE; Muir, Tom W TW

Publication Date: 2020-03-25

Variant appearance in text: K-Ras4B: Gln61Glu

PubMed Link: 31774265

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Atypical BRAF and NRAS Mutations in Mucosal Melanoma.

Cancers

Dumaz, Nicolas N; Jouenne, Fanélie F; Delyon, Julie J; Mourah, Samia S; Bensussan, Armand A; Lebbé, Céleste C

Publication Date: 2019-08-08

Variant appearance in text: KRAS: Q61E

PubMed Link: 31398831

Variant Present in the following documents:

• Main text
• cancers-11-01133.pdf

View BVdb publication page

---

Computational Screening and Analysis of Lung Cancer Related Non-Synonymous Single Nucleotide Polymorphisms on the Human Kirsten Rat Sarcoma Gene.

Molecules (Basel, Switzerland)

Wang, Qiankun Q; Mehmood, Aamir A; Wang, Heng H; Xu, Qin Q; Xiong, Yi Y; Wei, Dong-Qing DQ

Publication Date: 2019-05-21

Variant appearance in text: KRAS: Q61E; rs121913238

PubMed Link: 31117243

Variant Present in the following documents:

• Main text
• molecules-24-01951.pdf

View BVdb publication page

---

KRAS and NRAS pyrosequencing screening in Tunisian colorectal cancer patients in 2015.

Heliyon

Jouini, Raja R; Ferchichi, Marwa M; BenBrahim, Ehsen E; Ayari, Imen I; Khanchel, Fatma F; Koubaa, Wafa W; Saidi, Olfa O; Allani, Riadh R; Chadli-Debbiche, Aschraf A

Publication Date: 2019-03

Variant appearance in text: KRAS: Q61E

PubMed Link: 30949599

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Clinicopathological features and endoscopic characteristics of inverted sessile serrated adenomas/polyps.

Endoscopy International Open

Takashima, Kenji K; Oono, Yasuhiro Y; Kojima, Motohiro M; Ikematsu, Hiroaki H; Akimoto, Tetsuo T; Yano, Tomonori T

Publication Date: 2019-03

Variant appearance in text: KRAS: Q61E

PubMed Link: 30834291

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Comprehensive characterization of the mutational landscape in multiple myeloma cell lines reveals potential drivers and pathways associated with tumor progression and drug resistance.

Theranostics

Vikova, Veronika V; Jourdan, Michel M; Robert, Nicolas N; Requirand, Guilhem G; Boireau, Stéphanie S; Bruyer, Angélique A; Vincent, Laure L; Cartron, Guillaume G; Klein, Bernard B; Elemento, Olivier O; Kassambara, Alboukadel A; Moreaux, Jérôme J

Publication Date: 2019

Variant appearance in text: KRAS: Q61E

PubMed Link: 30809292

Variant Present in the following documents:

• thnov09p0540s1.pdf

View BVdb publication page

---

Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways.

Journal Of Hematology & Oncology

Tessoulin, Benoît B; Moreau-Aubry, Agnès A; Descamps, Géraldine G; Gomez-Bougie, Patricia P; Maïga, Sophie S; Gaignard, Alban A; Chiron, David D; Ménoret, Emmanuelle E; Le Gouill, Steven S; Moreau, Philippe P; Amiot, Martine M; Pellat-Deceunynck, Catherine C

Publication Date: 2018-12-13

Variant appearance in text: KRAS: 181C>G; Q61E; rs121913238

PubMed Link: 30545397

Variant Present in the following documents:

• 13045_2018_679_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

---

Iron removal enhances vitamin C-induced apoptosis and growth inhibition of K-562 leukemic cells.

Scientific Reports

Tsuma-Kaneko, Mitsuyo M; Sawanobori, Masakazu M; Kawakami, Shohei S; Uno, Tomoko T; Nakamura, Yoshihiko Y; Onizuka, Makoto M; Ando, Kiyoshi K; Kawada, Hiroshi H

Publication Date: 2018-11-26

Variant appearance in text: KRAS: Q61E

PubMed Link: 30478296

Variant Present in the following documents:

• Main text
• 41598_2018_Article_35730.pdf

View BVdb publication page

---

An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.

Scientific Reports

Collord, Grace G; Tarpey, Patrick P; Kurbatova, Natalja N; Martincorena, Inigo I; Moran, Sebastian S; Castro, Manuel M; Nagy, Tibor T; Bignell, Graham G; Maura, Francesco F; Young, Matthew D MD; Berna, Jorge J; Tubio, Jose M C JMC; McMurran, Chris E CE; Young, Adam M H AMH; Sanders, Mathijs M; Noorani, Imran I; Price, Stephen J SJ; Watts, Colin C; Leipnitz, Elke E; Kirsch, Matthias M; Schackert, Gabriele G; Pearson, Danita D; Devadass, Abel A; Ram, Zvi Z; Collins, V Peter VP; Allinson, Kieren K; Jenkinson, Michael D MD; Zakaria, Rasheed R; Syed, Khaja K; Hanemann, C Oliver CO; Dunn, Jemma J; McDermott, Michael W MW; Kirollos, Ramez W RW; Vassiliou, George S GS; Esteller, Manel M; Behjati, Sam S; Brazma, Alvis A; Santarius, Thomas T; McDermott, Ultan U

Publication Date: 2018-09-10

Variant appearance in text: KRAS: Q61E

PubMed Link: 30202034

Variant Present in the following documents:

• 41598_2018_31659_MOESM2_ESM.xlsx, sheet 30

View BVdb publication page

---

Methylome analysis and whole-exome sequencing reveal that brain tumors associated with encephalocraniocutaneous lipomatosis are midline pilocytic astrocytomas.

Acta Neuropathologica

Valera, Elvis Terci ET; McConechy, Melissa K MK; Gayden, Tenzin T; Rivera, Barbara B; Jones, David T W DTW; Wittmann, Andrea A; Han, HyeRim H; Bareke, Eric E; Nikbakht, Hamid H; Mikael, Leonie L; Queiroz, Rosane Gomes RG; Suazo, Veridiana Kiill VK; Phi, Ji Hoon JH; Kim, Seung-Ki SK; Park, Sung-Hye SH; Fukaya, Raita R; Yum, Mi-Sun MS; Ko, Tae-Sung TS; de Oliveira, Ricardo Santos RS; Machado, Helio Rubens HR; Brassesco, María Sol MS; do Santos, Antonio Carlos AC; Simão, Gustavo Novelino GN; Ramalho, Leandra Náira Zambelli LNZ; Neder, Luciano L; Scrideli, Carlos Alberto CA; Tone, Luiz Gonzaga LG; Majewski, Jacek J; Jabado, Nada N

Publication Date: 2018-10

Variant appearance in text: KRAS: Q61E

PubMed Link: 30143858

Variant Present in the following documents:

• 401_2018_1898_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

---

Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma.

Bmc Urology

Kim, Young Saing YS; Kim, Kyung K; Kwon, Ghee-Young GY; Lee, Su Jin SJ; Park, Se Hoon SH

Publication Date: 2018-07-31

Variant appearance in text: KRAS: 181C>G

PubMed Link: 30064409

Variant Present in the following documents:

• 12894_2018_380_MOESM1_ESM.xlsx, sheet 1

View BVdb publication page

---

Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine

Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L

Publication Date: 2018-07-27

Variant appearance in text: KRAS: Q61E

PubMed Link: 30053901

Variant Present in the following documents:

• 13073_2018_564_MOESM2_ESM.xlsx, sheet 2
• 13073_2018_564_MOESM2_ESM.xlsx, sheet 19
• 13073_2018_564_MOESM2_ESM.xlsx, sheet 13

View BVdb publication page

---

Phase II trial of biweekly cetuximab and irinotecan as third-line therapy for pretreated KRAS exon 2 wild-type colorectal cancer.

Cancer Science

Osumi, Hiroki H; Shinozaki, Eiji E; Mashima, Tetsuo T; Wakatsuki, Takeru T; Suenaga, Mitsukuni M; Ichimura, Takashi T; Ogura, Mariko M; Ota, Yumiko Y; Nakayama, Izuma I; Takahari, Daisuke D; Chin, Keisho K; Miki, Yoshio Y; Yamaguchi, Kensei K

Publication Date: 2018-08

Variant appearance in text: KRAS: Q61E

PubMed Link: 29908105

Variant Present in the following documents:

• Main text
• CAS-109-2567.pdf

View BVdb publication page

---

Feasibility study of cancer genome alterations identified by next generation sequencing: ABC study.

Japanese Journal Of Clinical Oncology

Naito, Yoichi Y; Takahashi, Hideaki H; Shitara, Kohei K; Okamoto, Wataru W; Bando, Hideaki H; Kuwata, Takeshi T; Kuboki, Yasutoshi Y; Matsumoto, Shingo S; Miki, Izumi I; Yamanaka, Takeharu T; Watanabe, Atsushi A; Kojima, Motohiro M

Publication Date: 2018-06-01

Variant appearance in text: KRAS: 181C>G

PubMed Link: 29659903

Variant Present in the following documents:

• hyy052supplementaltable1ionver1.xls, sheet 1

View BVdb publication page

---

Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer.

Cancer Cell

Hellmann, Matthew D MD; Nathanson, Tavi T; Rizvi, Hira H; Creelan, Benjamin C BC; Sanchez-Vega, Francisco F; Ahuja, Arun A; Ni, Ai A; Novik, Jacki B JB; Mangarin, Levi M B LMB; Abu-Akeel, Mohsen M; Liu, Cailian C; Sauter, Jennifer L JL; Rekhtman, Natasha N; Chang, Eliza E; Callahan, Margaret K MK; Chaft, Jamie E JE; Voss, Martin H MH; Tenet, Megan M; Li, Xue-Mei XM; Covello, Kelly K; Renninger, Andrea A; Vitazka, Patrik P; Geese, William J WJ; Borghaei, Hossein H; Rudin, Charles M CM; Antonia, Scott J SJ; Swanton, Charles C; Hammerbacher, Jeff J; Merghoub, Taha T; McGranahan, Nicholas N; Snyder, Alexandra A; Wolchok, Jedd D JD

Publication Date: 2018-05-14

Variant appearance in text: KRAS: Q61E

PubMed Link: 29657128

Variant Present in the following documents:

• mmc3.xlsx, sheet 3

View BVdb publication page

---

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

The Journal Of Pathology

Temko, Daniel D; Van Gool, Inge C IC; Rayner, Emily E; Glaire, Mark M; Makino, Seiko S; Brown, Matthew M; Chegwidden, Laura L; Palles, Claire C; Depreeuw, Jeroen J; Beggs, Andrew A; Stathopoulou, Chaido C; Mason, John J; Baker, Ann-Marie AM; Williams, Marc M; Cerundolo, Vincenzo V; Rei, Margarida M; Taylor, Jenny C JC; Schuh, Anna A; Ahmed, Ahmed A; Amant, Frédéric F; Lambrechts, Diether D; Smit, Vincent Thbm VT; Bosse, Tjalling T; Graham, Trevor A TA; Church, David N DN; Tomlinson, Ian I

Publication Date: 2018-07

Variant appearance in text: KRAS: 181C>G; Q61E

PubMed Link: 29604063

Variant Present in the following documents:

• PATH-245-283-s022.xlsx, sheet 1

View BVdb publication page

---

Dynamic changes of circulating tumour DNA in surgical lung cancer patients: protocol for a prospective observational study.

Bmj Open

Chen, Kezhong K; Zhao, Heng H; Yang, Fan F; Hui, Bengang B; Wang, Tianyang T; Wang, Lieu Tu LT; Shi, Yanbin Y; Wang, Jun J

Publication Date: 2018-02-06

Variant appearance in text: KRAS: Q61E

PubMed Link: 29437753

Variant Present in the following documents:

• Main text
• bmjopen-2017-019012.pdf

View BVdb publication page

---

Molecular Characterization of Urothelial Carcinoma of the Bladder and Upper Urinary Tract.

Translational Oncology

Lee, Ji Yun JY; Kim, Kyung K; Sung, Hyun Hwan HH; Jeon, Hwang Gyun HG; Jeong, Byong Chang BC; Seo, Seong Il SI; Jeon, Seong Soo SS; Lee, Hyun Moo HM; Choi, Han-Yong HY; Kwon, Ghee-Young GY; Kim, Kyoung-Mee KM; Lee, Jeeyun J; Lim, Ho Yeong HY; Park, Se Hoon SH

Publication Date: 2018-02

Variant appearance in text: KRAS: 181C>G; Q61E

PubMed Link: 29161613

Variant Present in the following documents:

• mmc1.xlsx, sheet 1

View BVdb publication page

---

Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nature Communications

Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ

Publication Date: 2017-08-04

Variant appearance in text: KRAS: 181C>G; Q61E

PubMed Link: 28775315

Variant Present in the following documents:

• 41467_2017_289_MOESM7_ESM.xlsx, sheet 1

View BVdb publication page

---

Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines.

Genome Medicine

Alfaro, Javier A JA; Ignatchenko, Alexandr A; Ignatchenko, Vladimir V; Sinha, Ankit A; Boutros, Paul C PC; Kislinger, Thomas T

Publication Date: 2017-07-18

Variant appearance in text: rs121913238

PubMed Link: 28716134

Variant Present in the following documents:

• 13073_2017_454_MOESM7_ESM.xlsx, sheet 1
• 13073_2017_454_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

---

A highly specific and sensitive massive parallel sequencer-based test for somatic mutations in non-small cell lung cancer.

Plos One

Inoue, Yoshiaki Y; Shiihara, Jun J; Miyazawa, Hitoshi H; Ohta, Hiromitsu H; Higo, Megumi M; Nagai, Yoshiaki Y; Kobayashi, Kunihiko K; Saijo, Yasuo Y; Tsuchida, Masanori M; Nakayama, Mitsuo M; Hagiwara, Koichi K

Publication Date: 2017

Variant appearance in text: KRAS: Q61E

PubMed Link: 28448556

Variant Present in the following documents:

• Main text
• pone.0176525.pdf
• pone.0176525.s006.xlsx, sheet 1

View BVdb publication page

---

Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research

Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U

Publication Date: 2017-04

Variant appearance in text: KRAS: 181C>G; Q61E

PubMed Link: 28179366

Variant Present in the following documents:

• supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1

View BVdb publication page

---

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.

Nature Communications

Van Emburgh, Beth O BO; Arena, Sabrina S; Siravegna, Giulia G; Lazzari, Luca L; Crisafulli, Giovanni G; Corti, Giorgio G; Mussolin, Benedetta B; Baldi, Federica F; Buscarino, Michela M; Bartolini, Alice A; Valtorta, Emanuele E; Vidal, Joana J; Bellosillo, Beatriz B; Germano, Giovanni G; Pietrantonio, Filippo F; Ponzetti, Agostino A; Albanell, Joan J; Siena, Salvatore S; Sartore-Bianchi, Andrea A; Di Nicolantonio, Federica F; Montagut, Clara C; Bardelli, Alberto A

Publication Date: 2016-12-08

Variant appearance in text: KRAS: Q61E

PubMed Link: 27929064

Variant Present in the following documents:

• ncomms13665-s1.pdf

View BVdb publication page

---

KRAS mutations in blood circulating cell-free DNA: a pancreatic cancer case-control.

Oncotarget

Le Calvez-Kelm, Florence F; Foll, Matthieu M; Wozniak, Magdalena B MB; Delhomme, Tiffany M TM; Durand, Geoffroy G; Chopard, Priscilia P; Pertesi, Maroulio M; Fabianova, Eleonora E; Adamcakova, Zora Z; Holcatova, Ivana I; Foretova, Lenka L; Janout, Vladimir V; Vallee, Maxime P MP; Rinaldi, Sabina S; Brennan, Paul P; McKay, James D JD; Byrnes, Graham B GB; Scelo, Ghislaine G

Publication Date: 2016-11-29

Variant appearance in text: KRAS: Q61E

PubMed Link: 27705932

Variant Present in the following documents:

• Main text

View BVdb publication page

---