Publications:

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Mutant p53 in cancer: from molecular mechanism to therapeutic modulation.

Cell Death & Disease

Chen, Xiaohua X; Zhang, Taotao T; Su, Wei W; Dou, Zhihui Z; Zhao, Dapeng D; Jin, Xiaodong X; Lei, Huiwen H; Wang, Jing J; Xie, Xiaodong X; Cheng, Bo B; Li, Qiang Q; Zhang, Hong H; Di, Cuixia C

Publication Date: 2022-11-18

Variant appearance in text: p53: S392A

PubMed Link: 36400749

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• 41419_2022_Article_5408.pdf

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STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392.

The Journal Of Biological Chemistry

Li, Dapei D; Xie, Lifen L; Qiao, Zigang Z; Mai, Sanyue S; Zhu, Jingfei J; Zhang, Fan F; Chen, Shengchuan S; Li, Liang L; Shen, Fangrong F; Qin, Yanghua Y; Yao, Haiping H; He, Sudan S; Ma, Feng F

Publication Date: 2021-08

Variant appearance in text: p53: S392A

PubMed Link: 34216619

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• main.pdf

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A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Sun, Xun X; Dyson, H Jane HJ; Wright, Peter E PE

Publication Date: 2021-01-05

Variant appearance in text: p53: S392A

PubMed Link: 33443163

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The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells.

Redox Biology

Zhang, Zili Z; Guo, Mei M; Shen, Min M; Kong, Desong D; Zhang, Feng F; Shao, Jiangjuan J; Tan, Shanzhong S; Wang, Shijun S; Chen, Anping A; Cao, Peng P; Zheng, Shizhong S

Publication Date: 2020-09

Variant appearance in text: p53: S392A

PubMed Link: 32863216

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Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53's DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption.

Cancers

Wang, Yu-Chu YC; Huang, Jau-Ling JL; Lee, Ka-Wo KW; Lu, Hsing-Han HH; Lin, Yuan-Jen YJ; Chen, Long-Fong LF; Wang, Chung-Sheng CS; Cheng, Yun-Chiao YC; Zeng, Zih-Ting ZT; Chu, Pei-Yi PY; Lin, Chang-Shen CS

Publication Date: 2020-07-25

Variant appearance in text: p53: S392A

PubMed Link: 32722430

Variant Present in the following documents:

• Main text
• cancers-12-02053.pdf

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How the Other Half Lives: What p53 Does When It Is Not Being a Transcription Factor.

International Journal Of Molecular Sciences

Ho, Teresa T; Tan, Ban Xiong BX; Lane, David D

Publication Date: 2019-12-18

Variant appearance in text: p53: S392A

PubMed Link: 31861395

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• Main text
• ijms-21-00013.pdf

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Dephosphorylation of p53 Ser 392 Enhances Trimethylation of Histone H3 Lys 9 via SUV39h1 Stabilization in CK2 Downregulation-Mediated Senescence.

Molecules And Cells

Park, Jeong-Woo JW; Bae, Young-Seuk YS

Publication Date: 2019-11-30

Variant appearance in text: p53: S392A

PubMed Link: 31617338

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• Main text
• molce-42-773_suppl.pdf
• molce-42-773.pdf

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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology

Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR

Publication Date: 2019-04

Variant appearance in text: TP53: S392A

PubMed Link: 31034466

Variant Present in the following documents:

• pcbi.1006981.s010.xlsx, sheet 1

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Stretching magnitude-dependent inactivation of AKT by ROS led to enhanced p53 mitochondrial translocation and myoblast apoptosis.

Molecular Biology Of The Cell

Song, Jing J; Wang, Yaqi Y; Yuan, Xiao X; Ji, Qiuxia Q; Fan, Cunhui C; Zhao, Hongmei H; Hao, Wenjing W; Ren, Dapeng D

Publication Date: 2019-05-01

Variant appearance in text: p53: S392A

PubMed Link: 30865562

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• Main text
• mbc-30-1182.pdf

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Regulators of Oncogenic Mutant TP53 Gain of Function.

Cancers

Yamamoto, Satomi S; Iwakuma, Tomoo T

Publication Date: 2018-12-20

Variant appearance in text: p53: S392A

PubMed Link: 30577483

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IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation.

Oncogenesis

Ishak Gabra, Mari B MB; Yang, Ying Y; Lowman, Xazmin H XH; Reid, Michael A MA; Tran, Thai Q TQ; Kong, Mei M

Publication Date: 2018-11-26

Variant appearance in text: p53: S392A

PubMed Link: 30478303

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• Main text
• 41389_2018_Article_104.pdf

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Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation.

Nature Communications

Zhang, Yanan Y; Wang, Jiancheng J; Huang, Weijun W; Cai, Jianye J; Ba, Junhui J; Wang, Yi Y; Ke, Qiong Q; Huang, Yinong Y; Liu, Xin X; Qiu, Yuan Y; Lu, Qiying Q; Sui, Xin X; Shi, Yue Y; Wang, Tao T; Shen, Huiyong H; Guan, Yuanjun Y; Zhou, Ying Y; Chen, Yuan Y; Wang, Maosheng M; Xiang, Andy Peng AP

Publication Date: 2018-09-06

Variant appearance in text: p53: S392A

PubMed Link: 30190500

Variant Present in the following documents:

• 41467_2018_5808_MOESM2_ESM.pdf

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A PINK1-mediated mitophagy pathway decides the fate of tumors-to be benign or malignant?

Autophagy

Qian, Hui H; Chao, Xiaojuan X; Ding, Wen-Xing WX

Publication Date: 2018

Variant appearance in text: TP53: S392A

PubMed Link: 29313453

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Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells.

Molecular Cell

Liu, Kai K; Lee, Jiyoung J; Kim, Ja Yeon JY; Wang, Linya L; Tian, Yongjun Y; Chan, Stephanie T ST; Cho, Cecilia C; Machida, Keigo K; Chen, Dexi D; Ou, Jing-Hsiung James JJ

Publication Date: 2017-10-19

Variant appearance in text: p53: S392A

PubMed Link: 29033320

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Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis.

Cell Death And Differentiation

Castrogiovanni, Cédric C; Waterschoot, Béranger B; De Backer, Olivier O; Dumont, Patrick P

Publication Date: 2018-01

Variant appearance in text: p53: S392A

PubMed Link: 28937686

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Emerging proteomics biomarkers and prostate cancer burden in Africa.

Oncotarget

Adeola, Henry A HA; Blackburn, Jonathan M JM; Rebbeck, Timothy R TR; Zerbini, Luiz F LF

Publication Date: 2017-06-06

Variant appearance in text: p53: S392A

PubMed Link: 28388542

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• Main text
• oncotarget-08-37991.pdf

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: TP53: S392A

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s5.xls, sheet 1

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Novel potential serological prostate cancer biomarkers using CT100+ cancer antigen microarray platform in a multi-cultural South African cohort.

Oncotarget

Adeola, Henry A HA; Smith, Muneerah M; Kaestner, Lisa L; Blackburn, Jonathan M JM; Zerbini, Luiz F LF

Publication Date: 2016-03-22

Variant appearance in text: p53: S392A

PubMed Link: 26885621

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UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation.

Oncotarget

Du, Cheng C; Wu, Hong H; Leng, Roger P RP

Publication Date: 2016-01-19

Variant appearance in text: p53: S392A

PubMed Link: 26673821

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• Main text
• oncotarget-07-2823.pdf

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FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15.

Oncotarget

Li, Ningning N; Lorenzi, Federica F; Kalakouti, Eliana E; Normatova, Makhliyo M; Babaei-Jadidi, Roya R; Tomlinson, Ian I; Nateri, Abdolrahman S AS

Publication Date: 2015-04-20

Variant appearance in text: p53: S392A

PubMed Link: 25860929

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• Main text
• oncotarget-06-9240.pdf

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Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway.

The Journal Of Biological Chemistry

Ji, Lei L; Xu, Jinjin J; Liu, Jian J; Amjad, Ali A; Zhang, Kun K; Liu, Qingwu Q; Zhou, Lei L; Xiao, Jianru J; Li, Xiaotao X

Publication Date: 2015-05-01

Variant appearance in text: p53: S392A

PubMed Link: 25767119

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ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells.

Cell Death & Disease

Ci, Y Y; Shi, K K; An, J J; Yang, Y Y; Hui, K K; Wu, P P; Shi, L L; Xu, C C

Publication Date: 2014-11-27

Variant appearance in text: p53: S392A

PubMed Link: 25429619

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• Main text
• cddis2014506a.pdf

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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology

Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B

Publication Date: 2014-10-28

Variant appearance in text: TP53: S392A

PubMed Link: 25348012

Variant Present in the following documents:

• 13059_2014_484_MOESM2_ESM.xlsx, sheet 1

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Mutant TP53 posttranslational modifications: challenges and opportunities.

Human Mutation

Nguyen, Thuy-Ai TA; Menendez, Daniel D; Resnick, Michael A MA; Anderson, Carl W CW

Publication Date: 2014-06

Variant appearance in text: TP53: Ser392Ala

PubMed Link: 24395704

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The rebel angel: mutant p53 as the driving oncogene in breast cancer.

Carcinogenesis

Walerych, Dawid D; Napoli, Marco M; Collavin, Licio L; Del Sal, Giannino G

Publication Date: 2012-11

Variant appearance in text: p53: S392A

PubMed Link: 22822097

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• Main text
• bgs232.pdf

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Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT.

Science Translational Medicine

Gasparian, Alexander V AV; Burkhart, Catherine A CA; Purmal, Andrei A AA; Brodsky, Leonid L; Pal, Mahadeb M; Saranadasa, Madhi M; Bosykh, Dmitry A DA; Commane, Mairead M; Guryanova, Olga A OA; Pal, Srabani S; Safina, Alfiya A; Sviridov, Sergey S; Koman, Igor E IE; Veith, Jean J; Komar, Anton A AA; Gudkov, Andrei V AV; Gurova, Katerina V KV

Publication Date: 2011-08-10

Variant appearance in text: p53: S392A

PubMed Link: 21832239

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Abl interconnects oncogenic Met and p53 core pathways in cancer cells.

Cell Death And Differentiation

Furlan, A A; Stagni, V V; Hussain, A A; Richelme, S S; Conti, F F; Prodosmo, A A; Destro, A A; Roncalli, M M; Barilà, D D; Maina, F F

Publication Date: 2011-10

Variant appearance in text: p53: S392A

PubMed Link: 21455220

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Research highlights on a notable retrovirus and a popular guardian gene.

Cell Cycle (Georgetown, Tex.)

Vogiatzi, Paraskevi P; Mason, Philip J PJ

Publication Date: 2010-12-15

Variant appearance in text: p53: S392A

PubMed Link: 21248483

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Transcriptional regulation of HIV-1 gene expression by p53.

Cell Cycle (Georgetown, Tex.)

Mukerjee, Ruma R; Claudio, Pier Paolo PP; Chang, J Robert JR; Del Valle, Luis L; Sawaya, Bassel E BE

Publication Date: 2010-11-15

Variant appearance in text: p53: S392A

PubMed Link: 21088492

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p53 post-translational modification: deregulated in tumorigenesis.

Trends In Molecular Medicine

Dai, Chao C; Gu, Wei W

Publication Date: 2010-11

Variant appearance in text: p53: S392A

PubMed Link: 20932800

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Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Cai, Xin X; Liu, Xuan X

Publication Date: 2008-11-04

Variant appearance in text: p53: S392A

PubMed Link: 18952844

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CFP1 interacts with DNMT1 independently of association with the Setd1 Histone H3K4 methyltransferase complexes.

Dna And Cell Biology

Butler, Jill Sergesketter JS; Lee, Jeong-Heon JH; Skalnik, David G DG

Publication Date: 2008-10

Variant appearance in text: p53: S392A

PubMed Link: 18680430

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The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53.

Plos One

Valbuena, Alberto A; Blanco, Sandra S; Vega, Francisco M FM; Lazo, Pedro A PA

Publication Date: 2008-07-09

Variant appearance in text: p53: S392A

PubMed Link: 18612383

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• Main text
• pone.0002649.pdf

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Critical role of p53 in histone deacetylase inhibitor-induced Epstein-Barr virus Zta expression.

Journal Of Virology

Chang, Shih-Shin SS; Lo, You-Chang YC; Chua, Huey-Huey HH; Chiu, Hsin-Yi HY; Tsai, Shu-Chun SC; Chen, Jen-Yang JY; Lo, Kwok-Wai KW; Tsai, Ching-Hwa CH

Publication Date: 2008-08

Variant appearance in text: p53: S392A

PubMed Link: 18495777

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Cancer cells activate p53 in response to 10-formyltetrahydrofolate dehydrogenase expression.

The Biochemical Journal

Oleinik, Natalia V NV; Krupenko, Natalia I NI; Priest, David G DG; Krupenko, Sergey A SA

Publication Date: 2005-11-01

Variant appearance in text: p53: S392A

PubMed Link: 16014005

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Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.

Molecular And Cellular Biology

Pise-Masison, C A CA; Mahieux, R R; Jiang, H H; Ashcroft, M M; Radonovich, M M; Duvall, J J; Guillerm, C C; Brady, J N JN

Publication Date: 2000-05

Variant appearance in text: p53: S392A

PubMed Link: 10779327

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