Publications:

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Synthetic lethality between TP53 and ENDOD1.

Nature Communications

Tang, Zizhi Z; Zeng, Ming M; Wang, Xiaojun X; Guo, Chang C; Yue, Peng P; Zhang, Xiaohu X; Lou, Huiqiang H; Chen, Jun J; Mu, Dezhi D; Kong, Daochun D; Carr, Antony M AM; Liu, Cong C

Publication Date: 2022-05-23

Variant appearance in text: TP53: H115N

PubMed Link: 35606358

Variant Present in the following documents:

• Main text
• 41467_2022_Article_30311.pdf
• 41467_2022_30311_MOESM1_ESM.pdf

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p53 isoforms differentially impact on the POLι dependent DNA damage tolerance pathway.

Cell Death & Disease

Guo, Yitian Y; Rall-Scharpf, Melanie M; Bourdon, Jean-Christophe JC; Wiesmüller, Lisa L; Biber, Stephanie S

Publication Date: 2021-10-13

Variant appearance in text: p53: H115N

PubMed Link: 34645785

Variant Present in the following documents:

• Main text
• 41419_2021_Article_4224.pdf

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p53 isoforms differentially impact on the POLι dependent DNA damage tolerance pathway.

Cell Death & Disease

Guo, Yitian Y; Rall-Scharpf, Melanie M; Bourdon, Jean-Christophe JC; Wiesmüller, Lisa L; Biber, Stephanie S

Publication Date: 2021-10-13

Variant appearance in text: p53: H115N

PubMed Link: 34645785

Variant Present in the following documents:

• Main text
• 41419_2021_Article_4224.pdf

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A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases.

Scientific Reports

Magraner-Pardo, Lorena L; Laskowski, Roman A RA; Pons, Tirso T; Thornton, Janet M JM

Publication Date: 2021-07-12

Variant appearance in text: TP53: 343C>A; His115Asn

PubMed Link: 34253785

Variant Present in the following documents:

• 41598_2021_93715_MOESM2_ESM.xlsx, sheet 8

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How the Other Half Lives: What p53 Does When It Is Not Being a Transcription Factor.

International Journal Of Molecular Sciences

Ho, Teresa T; Tan, Ban Xiong BX; Lane, David D

Publication Date: 2019-12-18

Variant appearance in text: p53: H115N

PubMed Link: 31861395

Variant Present in the following documents:

• Main text
• ijms-21-00013.pdf

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The cancer-associated, gain-of-function TP53 variant P152Lp53 activates multiple signaling pathways implicated in tumorigenesis.

The Journal Of Biological Chemistry

Singh, Siddharth S; Kumar, Manoj M; Kumar, Sanjeev S; Sen, Shrinka S; Upadhyay, Pawan P; Bhattacharjee, Sayan S; M, Naveen N; Tomar, Vivek Singh VS; Roy, Siddhartha S; Dutt, Amit A; Kundu, Tapas K TK

Publication Date: 2019-09-20

Variant appearance in text: p53: H115N

PubMed Link: 31366730

Variant Present in the following documents:

• Main text

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From uncertainty to pathogenicity: clinical and functional interrogation of a rare TP53 in-frame deletion.

Cold Spring Harbor Molecular Case Studies

Quinn, Emily A EA; Maciaszek, Jamie L JL; Pinto, Emilia M EM; Phillips, Aaron H AH; Berdy, David D; Khandwala, Mohammad M; Upadhyaya, Santhosh A SA; Zambetti, Gerard P GP; Kriwacki, Richard W RW; Ellison, David W DW; Nichols, Kim E KE; Kesserwan, Chimene C

Publication Date: 2019-08

Variant appearance in text: TP53: 343C>A; His115Asn

PubMed Link: 30886117

Variant Present in the following documents:

• supp_mcs.a003921_Supplemental_Table_1a.xlsx, sheet 1

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Roles of computational modelling in understanding p53 structure, biology, and its therapeutic targeting.

Journal Of Molecular Cell Biology

Tan, Yaw Sing YS; Mhoumadi, Yasmina Y; Verma, Chandra S CS

Publication Date: 2019-04-01

Variant appearance in text: p53: H115N

PubMed Link: 30726928

Variant Present in the following documents:

• Main text
• mjz009.pdf

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The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53.

Cancers

Gottifredi, Vanesa V; Wiesmüller, Lisa L

Publication Date: 2018-07-28

Variant appearance in text: p53: H115N

PubMed Link: 30060597

Variant Present in the following documents:

• Main text
• cancers-10-00250.pdf

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: TP53: H115N

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s5.xls, sheet 1

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DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Hampp, Stephanie S; Kiessling, Tina T; Buechle, Kerstin K; Mansilla, Sabrina F SF; Thomale, Jürgen J; Rall, Melanie M; Ahn, Jinwoo J; Pospiech, Helmut H; Gottifredi, Vanesa V; Wiesmüller, Lisa L

Publication Date: 2016-07-26

Variant appearance in text: p53: H115N

PubMed Link: 27407148

Variant Present in the following documents:

• Main text

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VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research.

Nucleic Acids Research

Lai, Zhongwu Z; Markovets, Aleksandra A; Ahdesmaki, Miika M; Chapman, Brad B; Hofmann, Oliver O; McEwen, Robert R; Johnson, Justin J; Dougherty, Brian B; Barrett, J Carl JC; Dry, Jonathan R JR

Publication Date: 2016-06-20

Variant appearance in text: TP53: 343C>A

PubMed Link: 27060149

Variant Present in the following documents:

• supp_gkw227_nar-03544-met-k-2015-File003.xls, sheet 2

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Mapping the structural and dynamical features of multiple p53 DNA binding domains: insights into loop 1 intrinsic dynamics.

Plos One

Lukman, Suryani S; Lane, David P DP; Verma, Chandra S CS

Publication Date: 2013

Variant appearance in text: p53: H115N

PubMed Link: 24324553

Variant Present in the following documents:

• Main text
• pone.0080221.pdf

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Targeting Chk1 in the replicative stress response.

Cell Cycle (Georgetown, Tex.)

Dai, Yun Y; Grant, Steven S

Publication Date: 2010-03-15

Variant appearance in text: p53: H115N

PubMed Link: 20237419

Variant Present in the following documents:

• cc-9-1025.pdf

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Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein.

Cell Cycle (Georgetown, Tex.)

Ahn, Jinwoo J; Poyurovsky, Masha V MV; Baptiste, Nicole N; Beckerman, Rachel R; Cain, Christine C; Mattia, Melissa M; McKinney, Kristine K; Zhou, Jianmin J; Zupnick, Andrew A; Gottifredi, Vanesa V; Prives, Carol C

Publication Date: 2009-05-15

Variant appearance in text: p53: H115N

PubMed Link: 19462533

Variant Present in the following documents:

• Main text

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