Replication stress defines distinct molecular subtypes across cancers.
Cancer Research Communications
Takahashi, Nobuyuki N; Kim, Sehyun S; Schultz, Christopher W CW; Rajapakse, Vinodh N VN; Zhang, Yang Y; Redon, Christophe E CE; Fu, Haiqing H; Pongor, Lorinc L; Kumar, Suresh S; Pommier, Yves Y; Aladjem, Mirit I MI; Thomas, Anish A
Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expression of Cyclin D1 and WEE1, phosphorylates TP53 and reduces cell proliferation in a kinase-dependent manner.
Cancer Gene Therapy
Woods, Michelle L ML; Weiss, Astrid A; Sokol, Anna M AM; Graumann, Johannes J; Boettger, Thomas T; Richter, Antje M AM; Schermuly, Ralph T RT; Dammann, Reinhard H RH
Epigenomic analysis reveals prevalent contribution of transposable elements to cis-regulatory elements, tissue-specific expression, and alternative promoters in zebrafish.
Genome Research
Lee, Hyung Joo HJ; Hou, Yiran Y; Maeng, Ju Heon JH; Shah, Nakul M NM; Chen, Yujie Y; Lawson, Heather A HA; Yang, Hongbo H; Yue, Feng F; Wang, Ting T
The MYCN inhibitor BGA002 restores the retinoic acid response leading to differentiation or apoptosis by the mTOR block in MYCN-amplified neuroblastoma.
Journal Of Experimental & Clinical Cancer Research : Cr
Lampis, Silvia S; Raieli, Salvatore S; Montemurro, Luca L; Bartolucci, Damiano D; Amadesi, Camilla C; Bortolotti, Sonia S; Angelucci, Silvia S; Scardovi, Anna Lisa AL; Nieddu, Giammario G; Cerisoli, Lucia L; Paganelli, Francesca F; Valente, Sabrina S; Fischer, Matthias M; Martelli, Alberto Maria AM; Pasquinelli, Gianandrea G; Pession, Andrea A; Hrelia, Patrizia P; Tonelli, Roberto R
G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy.
Science Advances
Alghamri, Mahmoud S MS; McClellan, Brandon L BL; Avvari, Ruthvik P RP; Thalla, Rohit R; Carney, Stephen S; Hartlage, Carson S CS; Haase, Santiago S; Ventosa, Maria M; Taher, Ayman A; Kamran, Neha N; Zhang, Li L; Faisal, Syed Mohd SM; Núñez, Felipe J FJ; Garcia-Fabiani, María Belén MB; Al-Holou, Wajd N WN; Orringer, Daniel D; Hervey-Jumper, Shawn S; Heth, Jason J; Patil, Parag G PG; Eddy, Karen K; Merajver, Sofia D SD; Ulintz, Peter J PJ; Welch, Joshua J; Gao, Chao C; Liu, Jialin J; Núñez, Gabriel G; Hambardzumyan, Dolores D; Lowenstein, Pedro R PR; Castro, Maria G MG
G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy.
Science Advances
Alghamri, Mahmoud S MS; McClellan, Brandon L BL; Avvari, Ruthvik P RP; Thalla, Rohit R; Carney, Stephen S; Hartlage, Margaret S MS; Haase, Santiago S; Ventosa, Maria M; Taher, Ayman A; Kamran, Neha N; Zhang, Li L; Faisal, Syed Mohd SM; Núñez, Felipe J FJ; Garcia-Fabiani, María Belén MB; Al-Holou, Wajd N WN; Orringer, Daniel D; Hervey-Jumper, Shawn S; Heth, Jason J; Patil, Parag G PG; Eddy, Karen K; Merajver, Sofia D SD; Ulintz, Peter J PJ; Welch, Joshua J; Gao, Chao C; Liu, Jialin J; Núñez, Gabriel G; Hambardzumyan, Dolores D; Lowenstein, Pedro R PR; Castro, Maria G MG
Cytosine base modifications regulate DNA duplex stability and metabolism.
Nucleic Acids Research
Rausch, Cathia C; Zhang, Peng P; Casas-Delucchi, Corella S CS; Daiß, Julia L JL; Engel, Christoph C; Coster, Gideon G; Hastert, Florian D FD; Weber, Patrick P; Cardoso, M Cristina MC
Cytosine base modifications regulate DNA duplex stability and metabolism.
Nucleic Acids Research
Rausch, Cathia C; Zhang, Peng P; Casas-Delucchi, Corella S CS; Daiß, Julia L JL; Engel, Christoph C; Coster, Gideon G; Hastert, Florian D FD; Weber, Patrick P; Cardoso, M Cristina MC
Immune evasion in HPV- head and neck precancer-cancer transition is driven by an aneuploid switch involving chromosome 9p loss.
Proceedings Of The National Academy Of Sciences Of The United States Of America
William, William N WN; Zhao, Xin X; Bianchi, Joy J JJ; Lin, Heather Y HY; Cheng, Pan P; Lee, J Jack JJ; Carter, Hannah H; Alexandrov, Ludmil B LB; Abraham, Jim P JP; Spetzler, David B DB; Dubinett, Steven M SM; Cleveland, Don W DW; Cavenee, Webster W; Davoli, Teresa T; Lippman, Scott M SM
The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3.
Nature Communications
Vaughan, Catherine A CA; Singh, Shilpa S; Subler, Mark A MA; Windle, Jolene J JJ; Inoue, Kazushi K; Fry, Elizabeth A EA; Pillappa, Raghavendra R; Grossman, Steven R SR; Windle, Brad B; Andrew Yeudall, W W; Deb, Swati Palit SP; Deb, Sumitra S
Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53's DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption.
Alterations in the Gut Microbiome and Suppression of Histone Deacetylases by Resveratrol Are Associated with Attenuation of Colonic Inflammation and Protection Against Colorectal Cancer.
Journal Of Clinical Medicine
Alrafas, Haider Rasheed HR; Busbee, Philip Brandon PB; Chitrala, Kumaraswamy Naidu KN; Nagarkatti, Mitzi M; Nagarkatti, Prakash P
Impact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients.
Breast Cancer Research : Bcr
Gao, Qiong Q; López-Knowles, Elena E; Cheang, Maggie Chon U MCU; Morden, James J; Ribas, Ricardo R; Sidhu, Kally K; Evans, David D; Martins, Vera V; Dodson, Andrew A; Skene, Anthony A; Holcombe, Chris C; Mallon, Elizabeth E; Evans, Abigail A; Bliss, Judith M JM; Robertson, John J; Smith, Ian I; Martin, Lesley-Ann LA; Dowsett, Mitch M; ,
Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV+ Cancers.
Cancer Immunology Research
Galliverti, Gabriele G; Wullschleger, Stephan S; Tichet, Mélanie M; Murugan, Dhaarini D; Zangger, Nadine N; Horton, Wesley W; Korman, Alan J AJ; Coussens, Lisa M LM; Swartz, Melody A MA; Hanahan, Douglas D
Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.
Chemical Science
Uhlenbrock, Niklas N; Smith, Steven S; Weisner, Jörn J; Landel, Ina I; Lindemann, Marius M; Le, Thien Anh TA; Hardick, Julia J; Gontla, Rajesh R; Scheinpflug, Rebekka R; Czodrowski, Paul P; Janning, Petra P; Depta, Laura L; Quambusch, Lena L; Müller, Matthias P MP; Engels, Bernd B; Rauh, Daniel D
Clinical whole-genome sequencing from routine formalin-fixed, paraffin-embedded specimens: pilot study for the 100,000 Genomes Project.
Genetics In Medicine : Official Journal Of The American College Of Medical Genetics
Robbe, Pauline P; Popitsch, Niko N; Knight, Samantha J L SJL; Antoniou, Pavlos P; Becq, Jennifer J; He, Miao M; Kanapin, Alexander A; Samsonova, Anastasia A; Vavoulis, Dimitrios V DV; Ross, Mark T MT; Kingsbury, Zoya Z; Cabes, Maite M; Ramos, Sara D C SDC; Page, Suzanne S; Dreau, Helene H; Ridout, Kate K; Jones, Louise J LJ; Tuff-Lacey, Alice A; Henderson, Shirley S; Mason, Joanne J; Buffa, Francesca M FM; Verrill, Clare C; Maldonado-Perez, David D; Roxanis, Ioannis I; Collantes, Elena E; Browning, Lisa L; Dhar, Sunanda S; Damato, Stephen S; Davies, Susan S; Caulfield, Mark M; Bentley, David R DR; Taylor, Jenny C JC; Turnbull, Clare C; Schuh, Anna A; ,
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.
Science (New York, N.Y.)
Engblom, Camilla C; Pfirschke, Christina C; Zilionis, Rapolas R; Da Silva Martins, Janaina J; Bos, Stijn A SA; Courties, Gabriel G; Rickelt, Steffen S; Severe, Nicolas N; Baryawno, Ninib N; Faget, Julien J; Savova, Virginia V; Zemmour, David D; Kline, Jaclyn J; Siwicki, Marie M; Garris, Christopher C; Pucci, Ferdinando F; Liao, Hsin-Wei HW; Lin, Yi-Jang YJ; Newton, Andita A; Yaghi, Omar K OK; Iwamoto, Yoshiko Y; Tricot, Benoit B; Wojtkiewicz, Gregory R GR; Nahrendorf, Matthias M; Cortez-Retamozo, Virna V; Meylan, Etienne E; Hynes, Richard O RO; Demay, Marie M; Klein, Allon A; Bredella, Miriam A MA; Scadden, David T DT; Weissleder, Ralph R; Pittet, Mikael J MJ
Individual outcome prediction for myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia from MDS after allogeneic hematopoietic cell transplantation.
Annals Of Hematology
Heuser, Michael M; Gabdoulline, Razif R; Löffeld, Patrick P; Dobbernack, Vera V; Kreimeyer, Henriette H; Pankratz, Mira M; Flintrop, Madita M; Liebich, Alessandro A; Klesse, Sabrina S; Panagiota, Victoria V; Stadler, Michael M; Wichmann, Martin M; Shahswar, Rabia R; Platzbecker, Uwe U; Thiede, Christian C; Schroeder, Thomas T; Kobbe, Guido G; Geffers, Robert R; Schlegelberger, Brigitte B; Göhring, Gudrun G; Kreipe, Hans-Heinrich HH; Germing, Ulrich U; Ganser, Arnold A; Kröger, Nicolaus N; Koenecke, Christian C; Thol, Felicitas F
Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non-Small Cell Lung Cancer.
Cancer Discovery
Adeegbe, Dennis O DO; Liu, Yan Y; Lizotte, Patrick H PH; Kamihara, Yusuke Y; Aref, Amir R AR; Almonte, Christina C; Dries, Ruben R; Li, Yuyang Y; Liu, Shengwu S; Wang, Xiaoen X; Warner-Hatten, Tiquella T; Castrillon, Jessica J; Yuan, Guo-Cheng GC; Poudel-Neupane, Neermala N; Zhang, Haikuo H; Guerriero, Jennifer L JL; Han, Shiwei S; Awad, Mark M MM; Barbie, David A DA; Ritz, Jerome J; Jones, Simon S SS; Hammerman, Peter S PS; Bradner, James J; Quayle, Steven N SN; Wong, Kwok-Kin KK
Vimentin regulates differentiation switch via modulation of keratin 14 levels and their expression together correlates with poor prognosis in oral cancer patients.
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.
Science (New York, N.Y.)
Yoon, Kyoung Wan KW; Byun, Sanguine S; Kwon, Eunjeong E; Hwang, So-Young SY; Chu, Kiki K; Hiraki, Masatsugu M; Jo, Seung-Hee SH; Weins, Astrid A; Hakroush, Samy S; Cebulla, Angelika A; Sykes, David B DB; Greka, Anna A; Mundel, Peter P; Fisher, David E DE; Mandinova, Anna A; Lee, Sam W SW
Structural and biochemical impact of C8-aryl-guanine adducts within the NarI recognition DNA sequence: influence of aryl ring size on targeted and semi-targeted mutagenicity.
Nucleic Acids Research
Sproviero, Michael M; Verwey, Anne M R AM; Rankin, Katherine M KM; Witham, Aaron A AA; Soldatov, Dmitriy V DV; Manderville, Richard A RA; Fekry, Mostafa I MI; Sturla, Shana J SJ; Sharma, Purshotam P; Wetmore, Stacey D SD
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Drosten, Matthias M; Sum, Eleanor Y M EY; Lechuga, Carmen G CG; Simón-Carrasco, Lucía L; Jacob, Harrys K C HK; García-Medina, Raquel R; Huang, Sidong S; Beijersbergen, Roderick L RL; Bernards, Rene R; Barbacid, Mariano M
Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1.
Molecular Oncology
Raab, Monika M; Krämer, Andrea A; Hehlgans, Stephanie S; Sanhaji, Mourad M; Kurunci-Csacsko, Elisabeth E; Dötsch, Christina C; Bug, Gesine G; Ottmann, Oliver O; Becker, Sven S; Pachl, Fiona F; Kuster, Bernhard B; Strebhardt, Klaus K