Publications:

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EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer.

Cell Reports

Kang, JiHoon J; Chun, Jaemoo J; Hwang, Jung Seok JS; Pan, Chaoyun C; Li, Jie J; Boese, Austin C AC; Young, Isabelle I; Malin, Courteney M CM; Kang, Yibin Y; Gibbons, Don L DL; Sica, Gabriel G; Fu, Haian H; Ramalingam, Suresh S SS; Jin, Lingtao L; Kang, Sumin S

Publication Date: 2022-12-13

Variant appearance in text: EGFR: D837A

PubMed Link: 36516759

Variant Present in the following documents:

• Main text
• nihms-1857928.pdf

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The mutational landscape of cancer's vulnerability to ionizing radiation.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Gopal, Priyanka P; Yard, Brian D BD; Petty, Aaron A; Lal, Jessica C JC; Bera, Titas K TK; Hoang, Trung Q TQ; Buhimschi, Alexandru B AB; Abazeed, Mohamed E ME

Publication Date: 2022-10-12

Variant appearance in text: EGFR: D837A

PubMed Link: 36222846

Variant Present in the following documents:

• ccr-22-1914_supplementary_data_2_suppds2.xlsx, sheet 1
• ccr-22-1914_supplementary_data_3_suppds3.xlsx, sheet 1

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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology

Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR

Publication Date: 2019-04

Variant appearance in text: EGFR: D837A

PubMed Link: 31034466

Variant Present in the following documents:

• pcbi.1006981.s010.xlsx, sheet 1

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Moderate and strong static magnetic fields directly affect EGFR kinase domain orientation to inhibit cancer cell proliferation.

Oncotarget

Zhang, Lei L; Wang, Jihao J; Wang, HongLei H; Wang, Wenchao W; Li, Zhiyuan Z; Liu, Juanjuan J; Yang, Xingxing X; Ji, Xinmiao X; Luo, Yan Y; Hu, Chen C; Hou, Yubin Y; He, Qianqian Q; Fang, Jun J; Wang, Junfeng J; Liu, Qingsong Q; Li, Guohui G; Lu, Qingyou Q; Zhang, Xin X

Publication Date: 2016-07-05

Variant appearance in text: EGFR: D837A

PubMed Link: 27223425

Variant Present in the following documents:

• Main text
• oncotarget-07-41527.pdf
• oncotarget-07-41527-s001.pdf

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Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.

Nature Structural & Molecular Biology

Park, Eunyoung E; Kim, Nayoung N; Ficarro, Scott B SB; Zhang, Yi Y; Lee, Byung Il BI; Cho, Ahye A; Kim, Kihong K; Park, Angela K J AKJ; Park, Woong-Yang WY; Murray, Bradley B; Meyerson, Matthew M; Beroukhim, Rameen R; Marto, Jarrod A JA; Cho, Jeonghee J; Eck, Michael J MJ

Publication Date: 2015-09

Variant appearance in text: EGFR: D837A

PubMed Link: 26280531

Variant Present in the following documents:

• Main text

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ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.

Oncotarget

Bill, Anke A; Gutierrez, Abraham A; Kulkarni, Sucheta S; Kemp, Carolyn C; Bonenfant, Debora D; Voshol, Hans H; Duvvuri, Umamaheswar U; Gaither, L Alex LA

Publication Date: 2015-04-20

Variant appearance in text: EGFR: D837A

PubMed Link: 25823819

Variant Present in the following documents:

• Main text

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MITF Modulates Therapeutic Resistance through EGFR Signaling.

The Journal Of Investigative Dermatology

Ji, Zhenyu Z; Erin Chen, Yiyin Y; Kumar, Raj R; Taylor, Michael M; Jenny Njauw, Ching-Ni CN; Miao, Benchun B; Frederick, Dennie T DT; Wargo, Jennifer A JA; Flaherty, Keith T KT; Jönsson, Göran G; Tsao, Hensin H

Publication Date: 2015-07

Variant appearance in text: EGFR: D837A

PubMed Link: 25789707

Variant Present in the following documents:

• Main text
• nihms-670893.pdf
• NIHMS670893-supplement-01.pdf

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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology

Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B

Publication Date: 2014-10-28

Variant appearance in text: EGFR: D837A

PubMed Link: 25348012

Variant Present in the following documents:

• 13059_2014_484_MOESM2_ESM.xlsx, sheet 1

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Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization.

Cancer Research

Cho, Jeonghee J; Chen, Liang L; Sangji, Naveen N; Okabe, Takafumi T; Yonesaka, Kimio K; Francis, Joshua M JM; Flavin, Richard J RJ; Johnson, William W; Kwon, Jihyun J; Yu, Soyoung S; Greulich, Heidi H; Johnson, Bruce E BE; Eck, Michael J MJ; Jänne, Pasi A PA; Wong, Kwok-Kin KK; Meyerson, Matthew M

Publication Date: 2013-11-15

Variant appearance in text: EGFR: D837A

PubMed Link: 24063894

Variant Present in the following documents:

• Main text

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Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion.

The American Journal Of Pathology

Whitsett, Timothy G TG; Cheng, Emily E; Inge, Landon L; Asrani, Kaushal K; Jameson, Nathan M NM; Hostetter, Galen G; Weiss, Glen J GJ; Kingsley, Christopher B CB; Loftus, Joseph C JC; Bremner, Ross R; Tran, Nhan L NL; Winkles, Jeffrey A JA

Publication Date: 2012-07

Variant appearance in text: EGFR: D837A

PubMed Link: 22634180

Variant Present in the following documents:

• Main text

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Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway.

Cancer Research

Schnidar, Harald H; Eberl, Markus M; Klingler, Stefan S; Mangelberger, Doris D; Kasper, Maria M; Hauser-Kronberger, Cornelia C; Regl, Gerhard G; Kroismayr, Renate R; Moriggl, Richard R; Sibilia, Maria M; Aberger, Fritz F

Publication Date: 2009-02-15

Variant appearance in text: EGFR: D837A

PubMed Link: 19190345

Variant Present in the following documents:

• Main text

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Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.

Plos Medicine

Greulich, Heidi H; Chen, Tzu-Hsiu TH; Feng, Whei W; Jänne, Pasi A PA; Alvarez, James V JV; Zappaterra, Mauro M; Bulmer, Sara E SE; Frank, David A DA; Hahn, William C WC; Sellers, William R WR; Meyerson, Matthew M

Publication Date: 2005-11

Variant appearance in text: EGFR: D837A

PubMed Link: 16187797

Variant Present in the following documents:

• Main text
• pmed.0020313.pdf

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