Publications:

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Patient-derived cell-based pharmacogenomic assessment to unveil underlying resistance mechanisms and novel therapeutics for advanced lung cancer.

Journal Of Experimental & Clinical Cancer Research : Cr

Yu, Namhee N; Hwang, Mihwa M; Lee, Youngjoo Y; Song, Bo Ram BR; Kang, Eun Hye EH; Sim, Hanna H; Ahn, Beung-Chul BC; Hwang, Kum Hui KH; Kim, Jihyun J; Hong, Sehwa S; Kim, Sunshin S; Park, Charny C; Han, Ji-Youn JY

Publication Date: 2023-01-30

Variant appearance in text: EGFR: R776G

PubMed Link: 36717865

Variant Present in the following documents:

• Main text
• 13046_2023_Article_2606.pdf

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Multiple mutations in the EGFR gene in lung cancer: a systematic review.

Translational Lung Cancer Research

Castañeda-González, Juan Pablo JP; Chaves, Juan José JJ; Parra-Medina, Rafael R

Publication Date: 2022-10

Variant appearance in text: EGFR: R776G

PubMed Link: 36386461

Variant Present in the following documents:

• Main text
• tlcr-11-10-2148.pdf

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Comprehensive characterization of genomic and radiologic features reveals distinct driver patterns of RTK/RAS pathway in ground-glass opacity pulmonary nodules.

International Journal Of Cancer

Yu, Fenglei F; Peng, Muyun M; Bai, Jing J; Zhu, Xiuli X; Zhang, Bingyu B; Tang, Jingqun J; Liu, Wenliang W; Chen, Chen C; Wang, Xiang X; Chen, Mingjiu M; Tan, Sichuang S; Sun, Yi Y; Liang, Qingchun Q; Li, Jina J; Hu, Yan Y; Liao, Aihui A; Hu, Huali H; He, Yu Y; Xiao, Xiao X; Wang, Bin B; Xing, Guanlan G; Xu, Yaping Y; Chen, Rongrong R; Xia, Xuefeng X; Chen, Xiaofeng X

Publication Date: 2022-12-01

Variant appearance in text: EGFR: R776G

PubMed Link: 36029220

Variant Present in the following documents:

• IJC-151-2020-s001.pdf
• IJC-151-2020.pdf

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Genomic Alterations Identification and Resistance Mechanisms Exploration of NSCLC With Central Nervous System Metastases Using Liquid Biopsy of Cerebrospinal Fluid: A Real-World Study.

Frontiers In Oncology

Shen, Fangfang F; Liang, Naixin N; Fan, Zaiwen Z; Zhao, Min M; Kang, Jing J; Wang, Xifang X; Hu, Qun Q; Mu, Yongping Y; Wang, Kai K; Yuan, Mingming M; Chen, Rongrong R; Guo, Wei W; Dong, Guilan G; Zhao, Jun J; Bai, Jun J

Publication Date: 2022

Variant appearance in text: EGFR: 2326C>G; R776G

PubMed Link: 35814426

Variant Present in the following documents:

• DataSheet_1.xlsx, sheet 2

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: EGFR: R776G

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

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Driver gene alterations profiling of Chinese non-small cell lung cancer and the effects of co-occurring alterations on immunotherapy.

Cancer Medicine

Sun, Shengjie S; Du, Wenjuan W; Sun, Qiong Q; Zhao, Xiao X; Qin, Boyu B; Shi, Duozhi D; Wan, Chong C; Wu, Zhiyong Z

Publication Date: 2021-10

Variant appearance in text: EGFR: Arg776Gly

PubMed Link: 34599863

Variant Present in the following documents:

• CAM4-10-7360-s002.xlsx, sheet 2

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Driver gene alterations profiling of Chinese non-small cell lung cancer and the effects of co-occurring alterations on immunotherapy.

Cancer Medicine

Sun, Shengjie S; Du, Wenjuan W; Sun, Qiong Q; Zhao, Xiao X; Qin, Boyu B; Shi, Duozhi D; Wan, Chong C; Wu, Zhiyong Z

Publication Date: 2021-10

Variant appearance in text: EGFR: Arg776Gly

PubMed Link: 34599863

Variant Present in the following documents:

• CAM4-10-7360-s002.xlsx, sheet 2

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Genomic Evolution in a Patient With Lung Adenocarcinoma With a Germline EGFR T790M Mutation.

Jto Clinical And Research Reports

Mäkinen, Netta N; Zhou, Meng M; Bemus, Meredith M; Nevin, Julius J; Nag, Anwesha A; Chen, Ruthia R; Colson, Yolonda L YL; Thorner, Aaron R AR; Oxnard, Geoffrey R GR; Meyerson, Matthew M; Sholl, Lynette M LM

Publication Date: 2021-04

Variant appearance in text: EGFR: R776G

PubMed Link: 34590005

Variant Present in the following documents:

• Main text
• main.pdf

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Next-generation sequencing-based identification of EGFR and NOTCH2 complementary mutations in non-small cell lung cancer.

Oncology Letters

Niu, Lin L; Dang, Chunyan C; Li, Lin L; Guo, Na N; Xu, Ying Y; Li, Xiangling X; Xu, Qian Q; Cheng, Luyang L; Zhang, Li L; Liu, Lei L

Publication Date: 2021-08

Variant appearance in text: EGFR: Arg776Gly

PubMed Link: 34149905

Variant Present in the following documents:

• Main text
• ol-22-02-12855.pdf

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Presentation of EGFR mutations in 162 family probands with multiple primary lung cancer.

Translational Lung Cancer Research

Li, Chunxiang C; Wang, Yalong Y; Su, Kai K; Liu, Yu Y; Wang, Liyu L; Zheng, Bo B; Yan, Na N; Yuan, Dawei D; Zhang, Yanxiang Y; Xue, Liyan L; Gao, Shugeng S; He, Jie J

Publication Date: 2021-04

Variant appearance in text: EGFR: R776G

PubMed Link: 34012789

Variant Present in the following documents:

• Main text

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The effectiveness of afatinib in patients with lung adenocarcinoma harboring complex epidermal growth factor receptor mutation.

Therapeutic Advances In Medical Oncology

Wu, Shang-Gin SG; Yu, Chong-Jen CJ; Yang, James Chih-Hsin JC; Shih, Jin-Yuan JY

Publication Date: 2020

Variant appearance in text: EGFR: R776G

PubMed Link: 32843903

Variant Present in the following documents:

• Main text
• 10.1177_1758835920946156.pdf

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The contribution of hereditary cancer-related germline mutations to lung cancer susceptibility.

Translational Lung Cancer Research

Liu, Mengyuan M; Liu, Xinyi X; Suo, Peisu P; Gong, Yuan Y; Qu, Baolin B; Peng, Xiumei X; Xiao, Wenhua W; Li, Yuemin Y; Chen, Yan Y; Zeng, Zhen Z; Lu, Yinying Y; Huang, Tanxiao T; Zhao, Yingshen Y; Liu, Ming M; Li, Lifeng L; Chen, Yaru Y; Zhou, Yanqing Y; Liu, Guifeng G; Yao, Jianfei J; Chen, Shifu S; Song, Lele L

Publication Date: 2020-06

Variant appearance in text: EGFR: R776G

PubMed Link: 32676327

Variant Present in the following documents:

• Main text
• tlcr-09-03-646.pdf

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: EGFR: R776G

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

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Inherited lung cancer: a review.

Ecancermedicalscience

de Alencar, Viviane Teixeira Loiola VTL; Formiga, Maria Nirvana MN; de Lima, Vladmir Cláudio Cordeiro VCC

Publication Date: 2020

Variant appearance in text: EGFR: R776G

PubMed Link: 32104210

Variant Present in the following documents:

• can-14-1008.pdf

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Characterization of acquired receptor tyrosine-kinase fusions as mechanisms of resistance to EGFR tyrosine-kinase inhibitors.

Cancer Management And Research

Xu, Haiyuan H; Shen, Jinge J; Xiang, Jianxing J; Li, Haiyan H; Li, Bing B; Zhang, Tengfei T; Zhang, Lu L; Mao, Xinru X; Jian, Hong H; Shu, Yongqian Y

Publication Date: 2019

Variant appearance in text: EGFR: R776G

PubMed Link: 31372039

Variant Present in the following documents:

• Main text
• cmar-11-6343.pdf

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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology

Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR

Publication Date: 2019-04

Variant appearance in text: EGFR: R776G

PubMed Link: 31034466

Variant Present in the following documents:

• pcbi.1006981.s010.xlsx, sheet 1

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Inherited lung cancer syndromes targeting never smokers.

Translational Lung Cancer Research

Yamamoto, Hiromasa H; Yatabe, Yasushi Y; Toyooka, Shinichi S

Publication Date: 2018-08

Variant appearance in text: EGFR: R776G

PubMed Link: 30225213

Variant Present in the following documents:

• Main text

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Clinical Analysis of Uncommon Epidermal Growth Factor Receptor Mutations in 16 Cases of Nonsmall Cell Lung Cancer.

Chinese Medical Journal

Hu, Ai-Min AM; Li, Yun-Song YS; Zhao, Dan D; Hu, Fan-Bin FB; Wang, Qun-Hui QH; Li, Bao-Lan BL

Publication Date: 2018-04-20

Variant appearance in text: EGFR: R776G

PubMed Link: 29664067

Variant Present in the following documents:

• CMJ-131-1005.pdf

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Treatment-associated TP53 DNA-binding domain missense mutations in the pathogenesis of secondary gliosarcoma.

Oncotarget

Pain, Margaret M; Wang, Huaien H; Lee, Eunjee E; Strahl, Maya M; Hamou, Wissam W; Sebra, Robert R; Zhu, Jun J; Yong, Raymund L RL

Publication Date: 2018-01-05

Variant appearance in text: EGFR: R776G

PubMed Link: 29416795

Variant Present in the following documents:

• Main text
• oncotarget-09-2603.pdf

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Real-world experience of afatinib as a first-line therapy for advanced EGFR mutation-positive lung adenocarcinoma.

Oncotarget

Liang, Sheng-Kai SK; Hsieh, Min-Shu MS; Lee, Meng-Rui MR; Keng, Li-Ta LT; Ko, Jen-Chung JC; Shih, Jin-Yuan JY

Publication Date: 2017-10-27

Variant appearance in text: EGFR: R776G

PubMed Link: 29163842

Variant Present in the following documents:

• oncotarget-08-90430-s001.pdf

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Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins.

Science Signaling

White, Katharine A KA; Ruiz, Diego Garrido DG; Szpiech, Zachary A ZA; Strauli, Nicolas B NB; Hernandez, Ryan D RD; Jacobson, Matthew P MP; Barber, Diane L DL

Publication Date: 2017-09-05

Variant appearance in text: EGFR: R776G

PubMed Link: 28874603

Variant Present in the following documents:

• Main text

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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology

Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B

Publication Date: 2014-10-28

Variant appearance in text: EGFR: R776G

PubMed Link: 25348012

Variant Present in the following documents:

• 13059_2014_484_MOESM2_ESM.xlsx, sheet 1

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Germ-line exon 21 EGFR mutations, V843I and P848L, in nonsmall cell lung cancer patients.

European Respiratory Review : An Official Journal Of The European Respiratory Society

Prim, Nathalie N; Legrain, Michele M; Guerin, Eric E; Mennecier, Bertrand B; Weingertner, Noelle N; Voegeli, Anne-Claire AC; Guenot, Dominique D; Maugard, Christine M CM; Quoix, Anne-Elisabeth AE; Beau-Faller, Michele M

Publication Date: 2014-09

Variant appearance in text: EGFR: R776G

PubMed Link: 25176975

Variant Present in the following documents:

• Main text
• err-23-133-390.pdf

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DNA-Mutation Inventory to Refine and Enhance Cancer Treatment (DIRECT): a catalog of clinically relevant cancer mutations to enable genome-directed anticancer therapy.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Yeh, Paul P; Chen, Heidi H; Andrews, Jenny J; Naser, Riyad R; Pao, William W; Horn, Leora L

Publication Date: 2013-04-01

Variant appearance in text: EGFR: R776G

PubMed Link: 23344264

Variant Present in the following documents:

• Main text

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Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma.

Bmc Cancer

Centeno, Irene I; Blay, Pilar P; Santamaría, Iñigo I; Astudillo, Aurora A; Pitiot, Ana S AS; Osorio, Fernando G FG; González-Arriaga, Patricia P; Iglesias, Fernando F; Menéndez, Primitiva P; Tardón, Adonina A; Freije, Jose M JM; Balbín, Milagros M

Publication Date: 2011-05-16

Variant appearance in text: EGFR: 2326C>G; R776G

PubMed Link: 21575252

Variant Present in the following documents:

• Main text
• 1471-2407-11-172.pdf

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