Publications:

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Genomic Landscape of Primary Resistance to Osimertinib Among Hispanic Patients with EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC): Results of an Observational Longitudinal Cohort Study.

Targeted Oncology

Chamorro, Diego F DF; Cardona, Andrés F AF; Rodríguez, July J; Ruiz-Patiño, Alejandro A; Arrieta, Oscar O; Moreno-Pérez, Darwin A DA; Rojas, Leonardo L; Zatarain-Barrón, Zyanya Lucia ZL; Ardila, Dora V DV; Viola, Lucia L; Recondo, Gonzalo G; Blaquier, Juan B JB; Martín, Claudio C; Raez, Luis L; Samtani, Suraj S; Ordóñez-Reyes, Camila C; Garcia-Robledo, Juan Esteban JE; Corrales, Luis L; Sotelo, Carolina C; Ricaurte, Luisa L; Cuello, Mauricio M; Mejía, Sergio S; Jaller, Elvira E; Vargas, Carlos C; Carranza, Hernán H; Otero, Jorge J; Archila, Pilar P; Bermudez, Maritza M; Gamez, Tatiana T; Russo, Alessandro A; Malapelle, Umberto U; de Miguel Perez, Diego D; de Lima, Vladmir C Cordeiro VCC; Freitas, Helano H; Saldahna, Erick E; Rolfo, Christian C; Rosell, Rafael R; ,

Publication Date: 2023-04-05

Variant appearance in text: EGFR: G863D

PubMed Link: 37017806

Variant Present in the following documents:

• Main text
• 11523_2023_Article_955.pdf

View BVdb publication page

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[Progress in Detection of EGFR Exon 20 Insertion Mutation and Targeted Therapies 
in Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Wang, Yulu Y; Chu, Tianqing T

Publication Date: 2023-02-20

Variant appearance in text: EGFR: G863D

PubMed Link: 36872052

Variant Present in the following documents:

• zgfazz-26-135.pdf

View BVdb publication page

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Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics

G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A

Publication Date: 2022

Variant appearance in text: EGFR: G863D

PubMed Link: 36561320

Variant Present in the following documents:

• Table2.xlsx, sheet 4
• Table3.xlsx, sheet 1

View BVdb publication page

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Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology

Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M

Publication Date: 2022

Variant appearance in text: EGFR: 2588G>A; G863D

PubMed Link: 35936718

Variant Present in the following documents:

• Table_4.xlsx, sheet 2

View BVdb publication page

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Molecular landscape of TP53 mutations in breast cancer and their utility for predicting the response to HER-targeted therapy in HER2 amplification-positive and HER2 mutation-positive amplification-negative patients.

Cancer Medicine

Liu, Binliang B; Yi, Zongbi Z; Guan, Yanfang Y; Ouyang, Quchang Q; Li, Chunxiao C; Guan, Xiuwen X; Lv, Dan D; Li, Lixi L; Zhai, Jingtong J; Qian, Haili H; Xu, Binghe B; Ma, Fei F; Zeng, Yixin Y

Publication Date: 2022-07

Variant appearance in text: EGFR: 2588G>A; G863D

PubMed Link: 35393784

Variant Present in the following documents:

• CAM4-11-2767-s001.xlsx, sheet 1

View BVdb publication page

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Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Oncogene

Ikeuchi, Hiroshi H; Hirose, Takeshi T; Ikegami, Masachika M; Takamochi, Kazuya K; Suzuki, Kenji K; Mano, Hiroyuki H; Kohsaka, Shinji S

Publication Date: 2022-04

Variant appearance in text: EGFR: G863D

PubMed Link: 35304574

Variant Present in the following documents:

• 41388_2022_Article_2263.pdf

View BVdb publication page

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Efficacy of Immune Checkpoint Inhibitors in Patients With EGFR Mutated NSCLC and Potential Risk Factors Associated With Prognosis: A Single Institution Experience.

Frontiers In Immunology

Bai, Menglin M; Wang, Weiqing W; Gao, Xuetian X; Wu, Leilei L; Jin, Peng P; Wu, Hui H; Yu, Jinming J; Meng, Xue X

Publication Date: 2022

Variant appearance in text: EGFR: G863D

PubMed Link: 35296087

Variant Present in the following documents:

• Main text
• fimmu-13-832419.pdf

View BVdb publication page

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Identification of the Unique Clinical and Genetic Features of Chinese Lung Cancer Patients With EGFR Germline Mutations in a Large-Scale Retrospective Study.

Frontiers In Oncology

Lin, Xinqing X; Peng, Muyun M; Chen, Quanfang Q; Yuan, Mingming M; Chen, Rongrong R; Deng, Haiyi H; Deng, Jiaxi J; Liu, Ouqi O; Weng, Yuqing Y; Chen, Mingjiu M; Zhou, Chengzhi C

Publication Date: 2021

Variant appearance in text: EGFR: G863D

PubMed Link: 34869019

Variant Present in the following documents:

• Main text
• fonc-11-774156.pdf

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: EGFR: G863D

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors.

Innovation (Cambridge (Mass.))

Du, Xiaojing X; Yang, Biwei B; An, Quanlin Q; Assaraf, Yehuda G YG; Cao, Xin X; Xia, Jinglin J

Publication Date: 2021-05-28

Variant appearance in text: EGFR: G863D

PubMed Link: 34557754

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors.

Innovation (New York, N.Y.)

Du, Xiaojing X; Yang, Biwei B; An, Quanlin Q; Assaraf, Yehuda G YG; Cao, Xin X; Xia, Jinglin J

Publication Date: 2021-05-28

Variant appearance in text: EGFR: G863D

PubMed Link: 34557754

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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A Nationwide Study on the Impact of Routine Testing for EGFR Mutations in Advanced NSCLC Reveals Distinct Survival Patterns Based on EGFR Mutation Subclasses.

Cancers

Koopman, Bart B; Cajiao Garcia, Betzabel N BN; Kuijpers, Chantal C H J CCHJ; Damhuis, Ronald A M RAM; van der Wekken, Anthonie J AJ; Groen, Harry J M HJM; Schuuring, Ed E; Willems, Stefan M SM; van Kempen, Léon C LC

Publication Date: 2021-07-20

Variant appearance in text: EGFR: G863D

PubMed Link: 34298851

Variant Present in the following documents:

• Main text
• cancers-13-03641.pdf

View BVdb publication page

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Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer

Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA

Publication Date: 2021-05

Variant appearance in text: EGFR: 2588G>A; G863D

PubMed Link: 33704917

Variant Present in the following documents:

• TCA-12-1271-s003.xls, sheet 1

View BVdb publication page

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Molecular landscape and efficacy of HER2-targeted therapy in patients with HER2-mutated metastatic breast cancer.

Npj Breast Cancer

Yi, Zongbi Z; Rong, Guohua G; Guan, Yanfang Y; Li, Jin J; Chang, Lianpeng L; Li, Hui H; Liu, Binliang B; Wang, Wenna W; Guan, Xiuwen X; Ouyang, Quchang Q; Li, Lixi L; Zhai, Jingtong J; Li, Chunxiao C; Li, Lifeng L; Xia, Xuefeng X; Yang, Ling L; Qian, Haili H; Yi, Xin X; Xu, Binghe B; Ma, Fei F

Publication Date: 2020

Variant appearance in text: EGFR: 2588G>A; G863D

PubMed Link: 33145402

Variant Present in the following documents:

• 41523_2020_201_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Risk factors of metachronous brain metastasis in patients with EGFR-mutated advanced non-small cell lung cancer.

Bmc Cancer

Ouyang, Wen W; Yu, Jing J; Zhou, Yan Y; Hu, Jing J; Huang, Zhao Z; Zhang, Junhong J; Xie, Conghua C

Publication Date: 2020-07-28

Variant appearance in text: EGFR: G863D

PubMed Link: 32723319

Variant Present in the following documents:

• Main text
• 12885_2020_Article_7202.pdf

View BVdb publication page

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Landscape of drug-resistance mutations in kinase regulatory hotspots.

Briefings In Bioinformatics

Kim, Pora P; Li, Hanyang H; Wang, Junmei J; Zhao, Zhongming Z

Publication Date: 2021-05-20

Variant appearance in text: EGFR: G863D

PubMed Link: 32510566

Variant Present in the following documents:

• Main text

View BVdb publication page

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: EGFR: G863D

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

View BVdb publication page

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Development and validation of a targeted gene sequencing panel for application to disparate cancers.

Scientific Reports

McCabe, Mark J MJ; Gauthier, Marie-Emilie A MA; Chan, Chia-Ling CL; Thompson, Tanya J TJ; De Sousa, Sunita M C SMC; Puttick, Clare C; Grady, John P JP; Gayevskiy, Velimir V; Tao, Jiang J; Ying, Kevin K; Cipponi, Arcadi A; Deng, Niantao N; Swarbrick, Alex A; Thomas, Melissa L ML; Lord, Reginald V RV; Johns, Amber L AL; Kohonen-Corish, Maija M; O'Toole, Sandra A SA; Clark, Jonathan J; Mueller, Simon A SA; Gupta, Ruta R; McCormack, Ann I AI; Dinger, Marcel E ME; Cowley, Mark J MJ; ,

Publication Date: 2019-11-19

Variant appearance in text: EGFR: 2588G>A; G863D

PubMed Link: 31745186

Variant Present in the following documents:

• 41598_2019_52000_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Frequency, clinical features and differential response to therapy of concurrent ALK/EGFR alterations in Chinese lung cancer patients.

Drug Design, Development And Therapy

Liu, Jixian J; Mu, Zhimin Z; Liu, Li L; Li, Kang K; Jiang, Richeng R; Chen, Peng P; Zhou, Qiang Q; Jin, Meiling M; Ma, Yuxiang Y; Xie, Yuancai Y; Xiang, Jianxing J; Li, Bing B; Ma, Yafeng Y; Mao, Xinru X; Zhang, Lu L; Zhang, Tengfei T; Wu, Da D

Publication Date: 2019

Variant appearance in text: EGFR: G863D

PubMed Link: 31213769

Variant Present in the following documents:

• Main text
• dddt-13-1809.pdf

View BVdb publication page

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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology

Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR

Publication Date: 2019-04

Variant appearance in text: EGFR: G863D

PubMed Link: 31034466

Variant Present in the following documents:

• pcbi.1006981.s010.xlsx, sheet 1

View BVdb publication page

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Validation of the Oncomine™ focus panel for next-generation sequencing of clinical tumour samples.

Virchows Archiv : An International Journal Of Pathology

Williams, Hannah L HL; Walsh, Kathy K; Diamond, Austin A; Oniscu, Anca A; Deans, Zandra C ZC

Publication Date: 2018-10

Variant appearance in text: EGFR: 2588G>A

PubMed Link: 30105577

Variant Present in the following documents:

• 428_2018_2411_MOESM1_ESM.xlsx, sheet 3
• 428_2018_2411_MOESM1_ESM.xlsx, sheet 4
• 428_2018_2411_MOESM4_ESM.xlsx, sheet 1
• 428_2018_2411_MOESM3_ESM.xlsx, sheet 1
• 428_2018_2411_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Frequency, impact and a preclinical study of novel ERBB gene family mutations in HER2-positive breast cancer.

Therapeutic Advances In Medical Oncology

Elster, Naomi N; Toomey, Sinead S; Fan, Yue Y; Cremona, Mattia M; Morgan, Clare C; Weiner Gorzel, Karolina K; Bhreathnach, Una U; Milewska, Malgorzata M; Murphy, Madeline M; Madden, Stephen S; Naidoo, Jarushka J; Fay, Joanna J; Kay, Elaine E; Carr, Aoife A; Kennedy, Sean S; Furney, Simon S; Mezynski, Janusz J; Breathhnach, Oscar O; Morris, Patrick P; Grogan, Liam L; Hill, Arnold A; Kennedy, Susan S; Crown, John J; Gallagher, William W; Hennessy, Bryan B; Eustace, Alex A

Publication Date: 2018

Variant appearance in text: EGFR: G863D

PubMed Link: 30023006

Variant Present in the following documents:

• Supplementary_material.pdf

View BVdb publication page

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Next‑generation sequencing‑based detection of EGFR, KRAS, BRAF, NRAS, PIK3CA, Her‑2 and TP53 mutations in patients with non‑small cell lung cancer.

Molecular Medicine Reports

Jing, Changwen C; Mao, Xuhua X; Wang, Zhuo Z; Sun, Kejing K; Ma, Rong R; Wu, Jianzhong J; Cao, Haixia H

Publication Date: 2018-08

Variant appearance in text: EGFR: 2588G>A; G863D

PubMed Link: 29956783

Variant Present in the following documents:

• Main text
• mmr-18-02-2191.pdf

View BVdb publication page

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EGFR exon 20 insertion mutation in advanced thymic squamous cell carcinoma: Response to apatinib and clinical outcomes.

Thoracic Cancer

Yudong, Su S; Zhaoting, Meng M; Xinyue, Wang W; Li, Lin L; Xiaoyan, Xu X; Ran, Zuo Z; Jinliang, Chen C; Peng, Chen C

Publication Date: 2018-07

Variant appearance in text: EGFR: G863D

PubMed Link: 29740957

Variant Present in the following documents:

• Main text
• TCA-9-885.pdf

View BVdb publication page

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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One

Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS

Publication Date: 2018

Variant appearance in text: EGFR: G863D

PubMed Link: 29698444

Variant Present in the following documents:

• pone.0196434.s001.xlsx, sheet 3
• pone.0196434.s001.xlsx, sheet 2

View BVdb publication page

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Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation sequencing.

International Journal Of Oncology

Yamamoto, Gou G; Kikuchi, Mari M; Kobayashi, Shiho S; Arai, Yoshiko Y; Fujiyoshi, Kenji K; Wakatsuki, Tomokazu T; Kakuta, Miho M; Yamane, Yuki Y; Iijima, Yoshihito Y; Mizutani, Hideaki H; Nakajima, Yuki Y; Sudo, Junko J; Kinoshita, Hiroyasu H; Kurimoto, Futoshi F; Akiyama, Hirohiko H; Uramoto, Hidetaka H; Sakai, Hiroshi H; Akagi, Yoshito Y; Akagi, Kiwamu K

Publication Date: 2017-05

Variant appearance in text: EGFR: G863D

PubMed Link: 28350094

Variant Present in the following documents:

• Main text
• ijo-50-05-1579.pdf

View BVdb publication page

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Clinical significance of frequent somatic mutations detected by high-throughput targeted sequencing in archived colorectal cancer samples.

Journal Of Translational Medicine

Dallol, Ashraf A; Buhmeida, Abdelbaset A; Al-Ahwal, Mahmoud Shaheen MS; Al-Maghrabi, Jaudah J; Bajouh, Osama O; Al-Khayyat, Shadi S; Alam, Rania R; Abusanad, Atlal A; Turki, Rola R; Elaimi, Aisha A; Alhadrami, Hani A HA; Abuzenadah, Mohammed M; Banni, Huda H; Al-Qahtani, Mohammed H MH; Abuzenadah, Adel M AM

Publication Date: 2016-05-04

Variant appearance in text: EGFR: Gly863Asp

PubMed Link: 27146902

Variant Present in the following documents:

• Main text
• 12967_2016_Article_878.pdf

View BVdb publication page

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DBGC: A Database of Human Gastric Cancer.

Plos One

Wang, Chao C; Zhang, Jun J; Cai, Mingdeng M; Zhu, Zhenggang Z; Gu, Wenjie W; Yu, Yingyan Y; Zhang, Xiaoyan X

Publication Date: 2015

Variant appearance in text: EGFR: 2588G>A

PubMed Link: 26566288

Variant Present in the following documents:

• Main text
• pone.0142591.pdf

View BVdb publication page

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Epidermal growth factor receptor in non-small cell lung cancer.

Translational Lung Cancer Research

Prabhakar, Charles N CN

Publication Date: 2015-04

Variant appearance in text: EGFR: G863D

PubMed Link: 25870793

Variant Present in the following documents:

• Main text

View BVdb publication page

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Activation of oncogenic pathways in idiopathic pulmonary fibrosis.

Translational Oncology

Stella, Giulia M GM; Inghilleri, Simona S; Pignochino, Ymera Y; Zorzetto, Michele M; Oggionni, Tiberio T; Morbini, Patrizia P; Luisetti, Maurizio M

Publication Date: 2014-10

Variant appearance in text: EGFR: G863D

PubMed Link: 24935008

Variant Present in the following documents:

• Main text

View BVdb publication page

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KRAS, EGFR, PDGFR-α, KIT and COX-2 status in carcinoma showing thymus-like elements (CASTLE).

Diagnostic Pathology

Veits, Lothar L; Schupfner, Rupert R; Hufnagel, Petra P; Penzel, Roland R; Freitag, Jens J; Ströbel, Philipp P; Kern, Michael A MA; Schröder, Sören S; Neuhold, Nikolaus N; Schmid, Kurt W KW; Schirmacher, Peter P; Hartmann, Arndt A; Rieker, Ralf J RJ

Publication Date: 2014-06-16

Variant appearance in text: EGFR: G863D

PubMed Link: 24934485

Variant Present in the following documents:

• Main text
• 1746-1596-9-116.pdf

View BVdb publication page

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Drug resistance missense mutations in cancer are subject to evolutionary constraints.

Plos One

Friedman, Ran R

Publication Date: 2013

Variant appearance in text: EGFR: G863D

PubMed Link: 24376513

Variant Present in the following documents:

• Main text
• pone.0082059.pdf

View BVdb publication page

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EGFR mutational status in a large series of Caucasian European NSCLC patients: data from daily practice.

British Journal Of Cancer

Gahr, S S; Stoehr, R R; Geissinger, E E; Ficker, J H JH; Brueckl, W M WM; Gschwendtner, A A; Gattenloehner, S S; Fuchs, F S FS; Schulz, C C; Rieker, R J RJ; Hartmann, A A; Ruemmele, P P; Dietmaier, W W

Publication Date: 2013-10-01

Variant appearance in text: EGFR: G863D

PubMed Link: 24002608

Variant Present in the following documents:

• Main text
• bjc2013511a.pdf

View BVdb publication page

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Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics

Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z

Publication Date: 2013

Variant appearance in text: EGFR: G863D

PubMed Link: 23819521

Variant Present in the following documents:

• 1471-2164-14-S3-S7-S1.xlsx, sheet 1

View BVdb publication page

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The energy landscape analysis of cancer mutations in protein kinases.

Plos One

Dixit, Anshuman A; Verkhivker, Gennady M GM

Publication Date: 2011

Variant appearance in text: EGFR: G863D

PubMed Link: 21998754

Variant Present in the following documents:

View BVdb publication page

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: EGFR: G863D

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

View BVdb publication page

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Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer.

Bmc Cancer

Peraldo-Neia, Caterina C; Migliardi, Giorgia G; Mello-Grand, Maurizia M; Montemurro, Filippo F; Segir, Raffaella R; Pignochino, Ymera Y; Cavalloni, Giuliana G; Torchio, Bruno B; Mosso, Luciano L; Chiorino, Giovanna G; Aglietta, Massimo M

Publication Date: 2011-01-25

Variant appearance in text: EGFR: G863D

PubMed Link: 21266046

Variant Present in the following documents:

• Main text
• 1471-2407-11-31.pdf

View BVdb publication page

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Mechanisms of drug resistance in kinases.

Expert Opinion On Investigational Drugs

Barouch-Bentov, Rina R; Sauer, Karsten K

Publication Date: 2011-02

Variant appearance in text: EGFR: G863D

PubMed Link: 21235428

Variant Present in the following documents:

• Main text

View BVdb publication page

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Limited copy number-high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies.

Molecular Cancer

Do, Hongdo H; Dobrovic, Alexander A

Publication Date: 2009-10-08

Variant appearance in text: EGFR: 2588G>A; G863D

PubMed Link: 19811662

Variant Present in the following documents:

• Main text

View BVdb publication page

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'Classical' but not 'other' mutations of EGFR kinase domain are associated with clinical outcome in gefitinib-treated patients with non-small cell lung cancer.

British Journal Of Cancer

Pallis, A G AG; Voutsina, A A; Kalikaki, Ar A; Souglakos, J J; Briasoulis, E E; Murray, S S; Koutsopoulos, A A; Tripaki, M M; Stathopoulos, E E; Mavroudis, D D; Georgoulias, V V

Publication Date: 2007-12-03

Variant appearance in text: EGFR: G863D

PubMed Link: 18000506

Variant Present in the following documents:

• Main text
• 6604068a.pdf

View BVdb publication page

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